The Effects Of Helicobacter Pylori On The Human Stomach

2999 WordsNov 24, 201412 Pages
Helicobacter pylori is structurally small, gram negative rods which is microaerophilic in nature and has capability of colonizing regularly in human stomach (Strausbaugh et al., 2002). Due to such colonizing capability, it is regarded as one of the most common bacterial pathogen present in almost 50% of the world’s population (Zhao et al., 2014) and the reason behind such well adaptation or enduring of H.pylori in the Human’s stomach is due to the combined effects of several factors that addresses different challenges or obstacles presented by the nasty environment inside the stomach (Montecucco and Rappuoli, 2001). Helicobacter pylori produce the urease that neutralize the gastric acid or shows the buffering effect around the surroundings within the stomach. Moreover, it has a capacity of crossing the thick mucus lining of the stomach easily and binding itself to the antigen known as Lewis antigen that are basically present in gastric cells and whose function is to secrete different factors associated with stimulating and attracting the inflammatory cells and Toxin VacA that performs the multiple functions and such activities of H.pylori is possible due to its helicoidal shape the mode of action of flagella present. Mainly, the presence of the cag pathogenicity island (Cag-PAI) which is a 40-kb DNA insertion elements containing 32 genes and encoding a type IV secretion system helps in the optimal fitness of the bacteria in the stomach and appearance of pathogenic traits.
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