The Effects Of Iron Concentration On Brain Tissue

3722 Words Sep 23rd, 2014 15 Pages
Abstract
Quantification of iron concentration in brain tissue has always been of interest due to its role in normal aging and pathological processes such as Parkinson’s disease, Alzheimer’s disease and many others. More recently, contrast in brain tissue resulting from magnetic susceptibility has been exploited to assist in segmentation of deep grey matter structures.

Introduction
The most cited publication on brain iron concentration was published by Hallgren and Sourander in 1958 and has been well referenced in literature where many studies have attempted to compare their findings on measured brain iron concentration to a gold standard (Hallagren and Sourander, 1958). In their study, the authors use the Turnbull Blue Method to stain for iron in cadaveric brains, Toluidine blue for nerve cells and Palmgren’s silver for nerve fibres. The results were expressed in quadratic formulas that quantify concentration of several white and grey matter structures as a function of age.
Another more recent ex-vivo study that quantifies brain iron is carried out by Zheng et al (2013) using x-ray fluorescence imaging. It provides voxel-by-voxel quantification which enables comparisons to MRI acquired iron concentration.
While these techniques provide exact brain iron concentration, in-vivo quantification is desirable as a method to study and predict disease progression as well as structural changes due to the normal aging process. Additionally, while developing suitable MRI techniques…
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