The Effects Of Prophylactic Treatment On Children With Severe Haemophilia

Hemophilia is a condition where a person's blood is unable to clot properly. This condition can make a simple dental procedure more risky. People who have hemophilia will also have a harder time healing after a dental procedure. You definitely want to let your dentist know if you have hemophilia.

Hemophilia is an X-linked recessive disease in which blood lacks blood-clotting proteins. Females have two X chromosomes, indicating that they are generally carriers and transmit the gene to their sons. People with mild hemophilia bleed after surgery, injury, or trauma. Severe hemophilia produces spontaneous internal bleeding in joints and muscles. Fortunately, medicines and lifestyle changes offers hemophiliacs fairly normal lives. Through learning about hemophilia, I became interested in genetic diseases and finding a cure for those

As the best of my knowledge I believe the two year old child is suffering from an inherited disorder called hemophilia. The Mayo Clinic describes hemophilia as a rare blood disorder that lacks sufficient blood clotting proteins. (Staff, B.M. ((n.d.)). Hemophilia. Retrieved September 27, 2016, from http://www.mayoclinic.org/disease-conditions/hemophilia/basics/treatment/con-20029824

The genetic disorder of Hemophilia is where the clotting factors of the blood are absent or deficient, causing it to be a dangerous disorder to the people who have it. This disorder is where the people who have it will bleed easily and accessibly. Different types of hemophilia are classified by different deficient clotting factors in the blood. Treatments for hemophilia are available, including transfusions of frozen

Meyers, R., W. Adams, K. Dardick, J. Reinisch, F. Reyn, T. Renna, and O. McIntyre. "The Social and Economic Impact of Hemophilia--a Survey of 70 Cases in Vermont and New Hampshire." The Social and Economic Impact of Hemophilia--a Survey of 70 Cases in Vermont and New Hampshire. American Journals of Public Health, 1 Apr. 1972. Web. 30 Aug. 2015. .

Haemophilia is a genetic disorder that is passed through generations on the x chromosomes, that affects the clotting factor in the blood and makes patients more prone to spontaneous and injury-resulted bleeding which is usually internal. According to the Haemophilia Foundation Australia (2015), there are over 3,000 cases of haemophilia in Australia, and more than half the cases are in males. The National Haemophilia Foundation (2013) website shows that cases of haemophilia go back to the 2n d century, where Jewish boys who have records of uncontrollable bleeding leading to death in their family do not have to undergo circumcision, also cases in 10th century Arabia show deaths of males after uncontrollable bleeding due to trauma. The first

The Arab physician Albucasis, who lived in the 12th century, wrote of a family whose males died of bleeding after minor injuries. Then, in 1803, a Philadelphia physician named Dr. John Conrad Otto wrote an account of a hemorrhagic disposition existing in certain families '. He recognized that the condition was hereditary and affected males (Society). The diagnosis of hemophilia is actually quite simple. Blood labs are drawn if a doctor suspects their patient to have a bleeding disorder. Blood tests will indicate what percentage of clotting factors are present in the blood. There are three types of hemophilia.

A mutation called an inversion is present which entirely changes the gene up to the point where it can't even make it which then causes the absence of the factor 8 protein. Symptoms include Severe or light bleeding due to the unstable clot which doesn’t do its job properly. Continuous bleeding will occur and can result in major complications of the joints, organs, brain, muscles, and others. In infants, bruising can be in effect all around the body after his/her first birthday, and bleeding(even from a tooth eruption). This is a sex-linked disease which effect about one in every four thousand or five thousand males no matter the ethnic group, but in females, it is even rarer. One of the people who came by this disease was Paul. Paul is from colorado and would always get injections from his own mom who was a nurse when he was an infant. He went to a Hemophilia camp in colorado and would practice injecting his treatment into practice objects so he could do it one day to himself. Paul said that he couldn’t really be apart of everyday life with people and the crowd because he always had to worry about the bleeding and hardships of

As previously mentioned, hemophilia A varies in severity, which in turn includes symptoms (Iorio et al., 2010). Obviously the main symptom is excessive bleeding. Usually, hemophilia A is first noticed when an infant is circumcised (Iorio et al., 2010), however milder cases of hemophilia can be noticed later in life. If this is the case, mild cases can go unnoticed until after a surgery or injury in which internal bleeding would be a problem (Iorio et al., 2010). In addition, victims of hemophilia are recommended to get a hepatitis B vaccine due to the fact that they may receive blood products (Iorio et al.,

Megan is a 30yo, G2 P0010, who was seen for a consultation due to her history of seizures. She has had seizures since she was about 8 years old and is currently on Lamictal. She was on 600 mg daily but did have a seizure about 3 weeks ago and was seen by her neurologist and her Lamictal was increased to 800 mg daily. She has not had a seizure in the past 3+ weeks. Overall on today’s assessment she has no complaints.

Hemophilia is the oldest known hereditary bleeding disorder. There are two types of hemophilia, A and B (Christmas Disease). Low levels or complete absence of a blood protein essential for clotting causes both. Patients with hemophilia A lack the blood clotting protein, factor VIII, and those with hemophilia B lack factor IX. A person with severe hemophilia has less than 1% of the normal amount of a clotting factor - either Factor VIII (8) or Factor IX (9). People without hemophilia have between 50-150% of the normal level of factor VIII or IX. There are about 20,000 hemophilia patients in the United States. Each year, about 400 babies are born with this disorder. Approximately 85% have hemophilia A and the remainder has hemophilia B.

A. It 's important to know that hemophilia is not actually a disease or virus. https://my.clevelandclinic.org calls hemophilia "a rare hereditary (inherited) bleeding disorder in which blood cannot clot normally at the site of a wound or injury". This means that it is not contagious, rather it is passed down through genetics. When a hemophiliac gets injured,

Human beings contain tens of thousands of genes that decide what characteristic will each person have from the color of their eyes to their risk of contracting various disease. Amazingly, one misplaced gene can change a person life forever. For instance,is a rare bleeding disorder in which the blood doesn't clot normally. Hemophilia is a genetic disease where there is a defect in the series of protein that forms blood clots. The series of proteins is called the coagulation cascade in which each factor activate each other in chain reaction. The last to to activate is factor 10a which in turn activates thrombin. Thrombin is an enzyme that converts fibrinogen to fibrin. The large amounts of fibrin then forms long strands and merges with platelets

Occasionally a baby is born with this disorder and no family history of it. When this happens, it could be caused by a hidden gene, which is when several generations of female carry it, and it has not affected any male members of the family or a spontaneous mutation. With each pregnancy, a woman who is a carrier has a 25% possibility of having a son born with hemophilia. Since the father's X chromosome is what determines if the unborn child will be a girl, all of the daughters born of a man with hemophilia will be carriers. None of his sons, which is determined by the father through his Y chromosome, will have hemophilia. Individuals who suffer from mild hemophilia may choose to use a non-blood product known as Desmopressin acetate (DDAVP) to help treat the small bleeds and/or scrapes. For deep cuts or internal bleeding, the treatment called DDAVP may not be enough and therefore, may need a much more complex treatment. The clotting factor must be replenished so the affected person can form a clot to stop the bleeding. Plasma is one of the ‘human blood products’ than is used for factor replacement. Another factor replacement option is using the recombinant factor, which is produced in a laboratory.

Non-adherences to medication is widespread among patients (Margaret A. Chesney; 2000).An estimated average rate of patient that non-adhere to the antiretroviral (ARV) treatment therapy ranges from about 50-70%( Margaret A. Chesney; 2000)