The Effects of Metformin in People Undergoing Exercise Therapy

The study showed that the benefits of glucose reduction did not accrue for several years, and despite achieving statistical significance, the absolute risk reduction from intensive glycaemic control was small, with a reduction of 5 events over 10 years, and a small differential HbA1c between the conventional and intensive groups. Furthermore, due to the progressive nature of the disease, increasing combinations of oral and insulin drug therapy were introduced over to time to maintain the tight glycaemic control, therefore providing greater variability and a limited scope of comparison for statistical data on the efficacy of individual agents used amongst the patient cohorts.(King, Peacock, and Donnelly, 1999). This has raised further questions for clinicians in assessing how worthwhile are the benefits achieved with tighter glycaemic control, and how can targets be achieved in routine practice? It is not always clinically acceptable to maintain intensive glycaemic control, for example with the frail and elderly, or those with existing severe co-morbidities or complications. The Diabetes Control and Complications Trial follow up study reported that patients who achieved an average HbA1c value of 53mmol/mol had better outcomes after 20 years of follow-up than the control group (who had an average HbA1c of 75 mmol/mol), irrespective of

The study had an overall total of 1150 participants. Although there were many participants to begin with, they did not provide all of the feedback the researchers had requested.  This resulted in the expulsion of their participation, so their results were not included in the final reports of the study. The number of patients that did provide the essential information added up to a total of 901. The profile for a participant was a patients diagnosed with Type 2 diabetes in the last 6 months, but has been diagnosed no more than 10 years ago. They had to be between 35-70 years of age. Their BMI had to be more or less than 24 kg/m2 and have an HbA1c more or less than 6.5%. They also had to have treatment with a diet or oral glucose lowering medication. Those needing insulin shots, had been diagnosed with chronic diseases, or had a change in diet or lifestyle 3 months prior to the study were not included in the overall

The purpose of this study is to minimize the risk of hypoglycemia among the elderly. As people with diabetis age, the physiological changes affect the diabetic. The purpose of this study is to consider whether HbA1 goals can be attained without undue treatment burden and decrease the risk of severe hypoglycemia. Though client teaching and minimizing the risk factors of hypoglycemia can prevent further exacerbation of catastrophic events that could have potential lethal outcomes to an older patient with diabetes. The one patient’s case, Mr. J., an 86 year old man who has had type 2 diabetes for 15 years is a quantitative study that focuses on prevention of hypoglycemia in older adults. Interventions include diet, meal planning, medication, glucose

In order to combat the epidemic of type 2 diabetes in America, a series of subsidies and social programs promoting and mandating nutrition and exercise for weight loss should be created with the trillion dollar budget. The prevalence of type 2 diabetes in America is rising and has doubled over the last 30 years to 23 million (Campbell). Currently, it costs the nation about $90 billion a year to treat the complications of type 2 diabetes (Hoerger). Added with the co-morbidities of type 2 diabetes, namely cardiovascular disease, obesity, and kidney failure, it becomes apparent that drastic measures are needed. In order to combat this epidemic, the U.S. Congress is proposing to use a trillion dollars to do whatever it takes to reduce the

Diabetes (DM) is one the many initiatives that Healthy People 2020 have been focusing on to reduce this disease morbidity and mortality rates throughout the communities. In the United States alone, the number of individuals diagnosed with diabetes has increased from 1.5 million in 1958 to 25.8 million in 2011. The Center for Disease and prevention (CDC) also estimates in the year 2011, 79 million people age 20 and over were noted to have pre-diabetes, in which the blood sugar was higher than normal levels, however, have not reached the level for a diagnosis of DM. Eleven percent of those individuals with pre-diabetic readings of raised blood glucose will progress in full blown diabetes a matter of three years. Healthy People 2020 have used evidence –based practices to aid in the prevention and treatment of diabetes. Evidence have shown by simply modifying one’s lifestyle such regular exercising and healthy eating have been recognized to effectively prevent or delay the onset of type 2 diabetes in high-risk persons. Case in point, the Diabetes Prevention Program research trial revealed that the utilization of lifestyle interferences had its utmost impact in elderly adults and was also effective in all racial groups.

Evidence-based research was done in regards to combining diet and exercise programs to lower the risk of type II diabetes. They discovered that those that undertook these programs were able to see a decrease in periods of hypoglycemia and hyperglycemia and were able to maintain normoglycemic levels more easily. In addition they were able to decrease cardiovascular risk and lower blood pressure levels. (Healthy People 2020, 2014)

Staying active and getting enough exercise is needed to manage blood sugar levels and maintain a healthy weight. Getting help from a professional can help you get the most out of your exercise routine and motivate you to stick with it.

For example, increasing calorie intake increases body weight indicating a positive relationship. A negative correlation where the individual physical activity increases, the body weight decreases. A combination of a healthy eating plan, weight loss, and sufficient aerobic physical activity can help improve abnormal lipids and high blood pressure, hence, delaying and reducing the complications of diabetes. A successful example of prevention can be achieved via education to increase knowledge of diabetes risk factors and opening a fitness center in the community. As diabetes prevalence continues to rise, so does the cost of medical care. Therefore, exercise and proper nutrition are the cornerstones of prevention and treatment of

The individual used in this paper was a 56-year-old female that is pre-diabetic but is on the verge of having type 2 diabetes. The individual has been dealing with diabetes for the last 4 years. She stated that she was placed on Metformin 3 years ago to help control blood glucose levels. The individual states that she did not take her Metformin like she was suppose to and was having trouble keeping her A1C down. She stated that her primary care physician recommended she tried to control her blood glucose through diet and exercise and if she was able to do this she would be able to get of the Metformin.

Interventions used in treatment of type 2 diabetes should be those that improve the probability that the patient will have better long term control of diabetes. It is therefore imperative that early diagnosis is given fast priority especially when metabolic abnormalities of diabetes are less severe. Lifestyle interventions are key in containing type 2 diabetes. It is common knowledge that sedentary lifestyle and over nutrition which lead to obesity and overweight increase the risk of type 2 diabetes (Peters & Davidson, 1996). Interventions that reverse or improve these factors have beneficial effects on control of glycemia in established type 2 diabetes.

Many people suffer from type 2 diabetes, a type of metabolic disease (Curry et al., 2015; Hawley & Gibala, 2012). The prevalence of this disease has been increasing; one reason for this increase could be increased consumption of food as well as decreased prevalence of physical activity (Hawley & Gibala, 2012). Patients with type 2 diabetes are not able to metabolise glucose properly (Curry et al., 2015). Type 2 diabetes can cause patients to be very thirsty, excessively weary, and to experience a broad variety of other symptoms (Tovi & Engfeldt, 1998). It is often treated with insulin in order to help the body metabolise glucose (Tovi & Engfeldt, 1998). However, taking insulin can result in weight gain (Tovi & Engfeldt, 1998). Fat of the abdomen can be an indicator of the likelihood of developing cardiovascular disease in an individual with type 2 diabetes, which is heavily correlated with type 2 diabetes (Siren, Eriksson, & Vanhanen, 2012). In terms of lifestyle choices, type 2 diabetes patients are often told to focus on diet, but are also encouraged to increase frequency of physical activity (Alvarez et al., 2016; Hawley & Gibala, 2012). Physical activity has been shown to decrease the amount of deaths resulting from diabetes related causes (Church et al., 2004). Increased physical activity has been shown to help glucose metabolism in patients with type 2 diabetes (Curry et al., 2015). People who suffer

Metformin was tested with all the following adipocytokines, Visfatin, Adiponectin, Resistin and Leptin in patients with PCOS (Kong, W., Niu, X., Zeng, T., Lu, M., & Chen, L., 2015 ). The way this study was conducted was information from several other studies were compiled together and reviewed to come up with a final conclusion. There were many studies that were considered for this study but many were eliminated because they didn’t meet some of the requirements to be included. All of the studies that were considered for this study had to have values for the adipocytokines that were being tested both before and after metformin was taken. The way this study was conducted was that “each set of data studies were extracted independently by two reviewers using a standard data extraction form. Each set of data was recorded and then double checked.” (Kong, W., Niu, X., Zeng, T., Lu, M., & Chen, L., 2015). Each study included in the final study results went through three different analysis including a meta-analysis, a sensitivity analysis, and a special analysis. “The sensitivity analysis was performed to evaluate the stability of the results and a special analysis was performed on the effect of metformin on the body mass index in patients with PCOS” (Kong, W., Niu, X., Zeng, T., Lu, M., & Chen, L.,

Health benefits of taking Metformin are not only limited to regulating blood sugar levels and preventing risks associated with diabetes only. The drug can be prescribed because of additional gains

Studies have found that Metformin can affect submaximal exercise by increasing heart rate or ratings of perceived exertion. Prescription of exercise intensity is predominantly determined by these factors. Therefore, individuals taking metformin could reach a targeted heart rate or level of perceived exertion with lower workloads. This could have a significant impact on their energy expenditure or fitness gains (Boule, 2012).

Today, millions of new people become affected by type 2 diabetes every year. Diabetes ranks seventh among the leading causes of death in the United States and is causes more deaths than breast cancer and AIDS combined. Most people don't know how deadly this disease is. Weight loss is a primary goal towards preventing the disease. Therefore, almost every day companies introduce new medicines, pills, and diet plans that promise weight loss. These techniques are not always effective and they can be extremely expensive. However, there is an inexpensive old stand-by called “exercise” that has been proven over and over to reduce and control weight. Exercise is the most offered suggestion by doctors to prevent adult onset diabetes. People have to