The Efficacy Of Neurologic Deficits From Cerebral In Patients With Aneurysmal Subarachnoid Haemorrhage ( Asah )

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The efficacy of nimodipine in the reduction of neurologic deficits from cerebral vasospasm in patients with aneurysmal subarachnoid haemorrhage (aSAH)


Subarachnoid Haemorrhage (SAH) is the presence of blood in the subarachnoid space. It is characterised by sudden onset of severe headache, often described as “thunderclap headache”.[1] Eighty-five percent of the cases are caused by an aneurysm and 50% of patients diagnosed with SAH die.[2] The estimated incidence of SAH was at 10 to 15 per 100 000 person-years, but recent studies showed 6 to 8 per 100 000 person-years.[3] A New Zealand study in 1985 showed higher incidence rate of SAH in women than men.[4] Same findings were noted in one Australasian study conducted in 2000, wherein among the four neurosurgical units tested within Australia and New Zealand, results showed highest incidence of SAH in Auckland, attributing mainly to the high incidence of SAH among Maori and Pacific Islanders.[9] Cigarette smoking, uncontrolled hypertension, and excessive intake of alcohol remain to constitute the biggest threat [17]. Ten percent of the cases were also linked to a positive family history.[2] The risk is also increased during vigorous activities like physical exercise, Valsalva manoeuvre during defecation, micturition and sexual intercourse[19] relatively due to increased intracranial pressure associated with these mechanisms.
Despite recent advancements of SAH management, neurologic deficits secondary to cerebral
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