The Encapsulation And Site Directed Mechanisms

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3.c. Bioimaging mechanisms The encapsulation and site-directed mechanisms can also be translated and utilized in bioimaging – the field of study concerned with developing imaging techniques and devices that are used to obtain anatomical images and provide tissue analysis. Medical professionals are always looking for answers as to what is going on inside one’s body. Nanoparticles can serve as excellent scaffolds in this area of research because they have such a high surface area- to- volume ratio [9]. Ferritin, in particular, has been modified in different ways, mainly using the techniques described earlier, to further advancements in this field. Figure 7. (a). Ferritin nanocage with RGD surface modification and encapsulation of…show more content…
Recently, ferritin has been recognized as a potential contrast agent because it can overcome two critical issues – the difficulty of overcoming time-dependent imaging studies and the administration of high and repeated doses. There is evidence that ferritin is more stable to degradation than superparamagnetic iron oxide nanoparticles (SPIO), which are usually used [67]. And ferritin, as a natural protein in most organisms, allows it to be repeatedly injected if necessary. An in vivo study of apomaghemites (apoferritin encapsulated maghemite) proved this to be true. Results indicated that the apomaghemites, after accumulating in the liver, remained stable 45 days after injection, significantly longer than the standard SPIO, and did not have any toxic effects on the mice [67]. Researchers came to these conclusions after injecting two types of apomaghemites, 4 nm and 6 nm-based, and standard SPIO into the tail veins of mice. After injection, images were taken at various time intervals. The two types of apomaghemites were much more active than the standard SPIO, which gradually restored to normal levels after 7 days. The 6 nm-based apomaghemites lasted longer than the 4-nm based apomaghemites, probably because the 6 nm size is closer to the 8 nm size of the interior. The researchers thought that this contributed to an increased
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