The Encyclopedia Of Dna Elements

2407 WordsSep 2, 201410 Pages
The Encyclopedia of DNA Elements (ENCODE) is a project designed to compare and contrast the repertoire of RNAs produced by the human cells and cross verify with other methods like NGS. After a five year start-up since the beginning of the ENCODE project just 1% of the human genome has been observed and what was achieved was just the confirmation of the results of previous studies. RNA has functions of coding, regulation, decoding, and gene expression. RNA highlights the sequential output from genomes which gives the genetic information. They define the cells regulatory capabilities by their synthesis, translation, transport, processing, and modification. DNA, RNA and cellular proteins are the three most essential macromolecules responsible for the existence of life as we know it. This paper paves way for the generation of a catalogue that contains all the RNAs and their functions. The ENCODE project, which stands for Encyclopedia of DNA elements aims to catalogue and classify the RNA elements generated by human cells. This data acquisition is required to characterize and identify the functionalities that result due to the presence of the human genome sequence. The entire ENCODE project duration is divided into two phases: • Phase I: (1-5 years): examined 1% of the human genome • Phase II: (5-10 years): The interrogation of the complete human genome As per the findings of the ENCODE project, it is concluded that new RNAs consist of either of the two major cellular

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