The Endocrine System And Autoimmunity

Hashimoto’s Disease is a chronic Lymphocytic thyroiditis also known as autoimmune thyroiditis. It is due to chronic inflammation; the disease is a failure of the thyroid gland. Hashimoto’s disease is the most common inflammatory disorder of the thyroid and the leading cause of having hypothyroidism. The name of the disease came from a Japanese surgeon named Hashimoto Hakaru. Hakaru first described the chronic disease as Struma Lymphomatosa in a pathology report in the year 1912. Hashimoto’s Disease is a genetic trait and found to be more common in women then in men; and commonly found in women between the ages of thirty to fifty years of age. Hashimoto’s Disease can be found in children too; in the first-degree relatives that have the disease is found to have an increased incident.

Scientifically, Hashimoto’s Disease is, “a condition in which your immune system attacks your thyroid, a small gland at the base of your neck. The thyroid is a part of your endocrine system, which produces hormones that coordinate many of your body’s activities. The resulting inflammation from Hashimoto’s often leads to an under active thyroid” (Mayo Clinic.) Unfortunately, my thyroid didn’t work properly, and my body attacked it because of this.

Hashimoto’s Thyroiditis, also called Hashimoto’s disease is an autoimmune disease in which the body’s immune system attacks the thyroid gland. It was named for the Japanese surgeon who discovered it in 1912 The thyroid is a small butterfly shaped gland in the front of the neck. The thyroid makes hormones called T3 and T4. These hormones regulate metabolism. The thyroid is controlled by hormones of the pituitary gland, which is also called the “master gland.” It is a pea-sized gland located in the base of the brain which, among others, makes thyroid stimulating hormone, or TSH. TSH stimulates the thyroid to make thyroid hormone. With Hashimoto’s disease, the thyroid cells are damaged resulting in the inability to make enough thyroid

*Endocrine glands produce – hormones, they work with other hormones to perform many functions including: control water & electrolyte balance, regulating carbohydrate metabolism, working as neurotransmitters, maintaining stress & inflammation, regulate reproductive functions

Hashimoto thyroiditis is a common disease caused by hypothyroidism. The immune system cells attack the thyroid gland, causing inflammation and eventually destruction of the gland. This reduces the thyroids ability to make hormones. These hormones are known as thyroxine (T4) and tri-iodothyronine (T3) (Better health channel 2015).

To understand autoimmune diseases, the general characteristic of autoimmunity must be addressed. Autoimmunity is defined, in short, as “ misdirected immune response”. A healthy person is equipped with the mechanisms necessary to defend the body from pathogens within the immune system. When autoimmunity is present in an individual, something within the immune system is

There are several diseases that affect the endocrine system. The first one that I am going to discuss is Graves' disease which is an autoimmune problem that causes the thyroid gland to produce too much hormones. Even though this disease can affect anyone it is more common among women and before the age of 40. Some of the symptoms associated with this disease is anxiety, hand tremor, heat sensitivity, weight loss, puffy eyes, and enlarged thyroid. Once it is correctly diagnosed it can be easily treated. The part of the brain that is involved is the pituitary gland because it makes a hormones called TSH. Another disease that affects the endocrine system is Addison disease. It is a disorder that occurs when the adrenal glands do not produce enough

The endocrine system is a group of glands distributed throughout the human body. This group of glands secretes substances called hormones. These hormones are dumping into the bloodstream (Shier, Butler & Lewis, 2009). The endocrine system does not have a single anatomic location. It is dispersed throughout the human body. The final purpose of this process is to control, regulate, and coordinate the functioning of the human body. Some body functions can be activated or inhibited by hormones, which are secreted in very small quantities. The hormone related diseases may be due to hyper secretion, or a hypo secretion. The hormones secreted by the endocrine glands regulate growth, development and function of many tissues, and coordinate the

Hashimoto’s disease is also known as chronic lymphocytic thyroiditis-or- Hashimoto’s Thyroiditis. This disease was named after the Japanese doctor; Hakaru Hashimoto. This is a condition where your immune system creates antibodies that can damage your thyroid gland. The autoimmune disease creates inflammation with an increase in destruction and fibrosis of the thyroid gland. Your thyroid is a gland in your neck that secretes hormones. Hashimoto’s disease can sometimes lead to an underactive thyroid which can result in hypothyroidism. This is also the most common cause of hypothyroidism.

Hypothyroidism is defined by a reduction in the release of the main thyroid hormones, Thyroxine (T4) and Triiodothyronine (T3). These hormones are essential in the homeostatic maintenance in the area of metabolic function (PetMD, 2017). This condition is not life-threatening and is usually very inexpensive to treat (WebMD, 2017). While there are many causes for hypothyroidism, the common causes include shrinking of the thyroid gland, tumors or cancer of the thyroid, congenital disease, iodine deficiency, and sometimes even an autoimmune issue where the body attacks its own thyroid. The risk for this disease appears to increase when the animal is spayed or neutered for currently unknown reasons (WebMD 2016). This condition is most

People with Turner syndrome have an increased risk of developing autoimmune disorders that affect the thyroid gland. A condition called autoimmune thyroiditis, or Hashimoto's disease, is common among Turner syndrome patients. The disorder occurs when the immune system attacks the patient's thyroid gland, causing the thyroid to swell. The thyroid gland, located in the neck, produces hormones called triodothyronin (T3) and thyroxine (T4). These hormones control growth and the rate at which the body uses energy (metabolism). The inflammation caused by Hashimoto's disease often leads to an underactive thyroid gland, called hypothyroidism. Therefore, patients with the condition may experience slowed development and fatigue. Patients typically receive

Lost self-resistance causes autoimmunity in which the atypical insusceptible framework assaults the sound cells and tissues, prompting interminable aggravation. The immune system requires a strict balance of stable and reversible gene expression to maintain the normal function of immune cells and to ward off the development of autoimmune diseases. A gain of autoreactivity in immune cells as well as a loss of suppressive functions in regulatory T cells (Tregs) has been suggested to be implicated in the autoimmune pathogenesis. Recently, it has been demonstrated that not only genetic and environmental factors but also epigenetic changes are involved in the etiology of autoimmune diseases. Epigenetic mechanisms, such as histone modifications,

Hypothyroidism a common endocrine disorder resulting from deficiency of thyroid hormone which can cause symptoms such as fatigue, hair loss, and menstrual disturbances ("Hypothyroidism: Practice Essentials, Background, Pathophysiology," 2017).

Hashimoto's is an autoimmune disease, also known as Chronic Lymphocytic Thyroiditis. The thyroid is part of the endocrine system and it is below your adam's apple in your neck. In this case, your thyroid is "attacked" by your immune system, which can cause hypothyroidism. Hypothyroidism is the result of an underactive thyroid function, similar to Hashimoto's where your thyroid "retires" and quits functioning.

Autoimmunity is an immune response directed against an antigen within the body of the host. The definition does not distinguish whether the response is innate or acquired and, if acquired, whether it is induced by a foreign or autochthonous antigen. It usually involves both T-cell and B-cell responses. It only requires that the immune response be directed to a