The Epidemic Of Ebola Virus

926 Words Sep 28th, 2014 4 Pages
Background and introduction:
The highly dangerous virus- Ebola, causes high fever and death of 90% patients within days. Ebola virus and marburvirus are consider to be the most deadly human pathogens that cause severe fever syndrome in both humans and non human parasites. The virus is further divided into 5 species with different pathogenicities. 1. Zaire virus - most lethal, causing deaths of almost 90% people
2. SEBOV- Sudan Ebola virus, case-fatality rate about 50%.
3. CIEBOV- Côte d 'Ivoire Ebola virus, Linked to single non-fatal disease
4. BEBOV- Bundibugyo Ebola virus, newly discovered, 25% fatality rate
5. REBOV- Reston Ebola virus, caused a huge outbreak in non-human primates These viruses replicate massively in macrophage and dendritic cells, and then spread to all the other organs. When experimented on mice, it was observed that the virus is associated with impairment of innate immune responses which include important secretions of specific inflammatory mediators and also suppress adaptive immune responses. However, the experimentally infected animal models fail to show some symptoms as seen in human infections. The non-human models are one of the best models which mimic fatal infections, but they cannot reproduce small percent of patients. Only four studies of human infections were reported as of now. In the first study, there was a slight range in the serum level where as in second a huge difference was observed. This was later suggested that the fatal…

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