The Erk Mapk Pathway Causes Osteoporosis And Formation During Bone Remodeling

Calcium helps to keep bones strong but just drinking milk doesn’t mean that you won’t get osteoporosis. You may be genetically inclined to get it even though you drink milk every day. There are also many other things that contribute to getting osteoporosis, like not eating enough calcium, doing steroids causes bones to become weak and look like sponges when looking at it under a microscope. Scenarios A,B, and C help to explain that it’s not just the calcium that can cause osteoporosis Scenario A: 1. The…

-Marissa- Bones function in our body by providing structural support, protection, attachment sites for muscles, mineral storage, fat storage, and even involved in the formation of blood cells. The two types of bone in our body are compact bone (which is found forming the outer layer of bones for protection and support) and spongy bone (which is composed of an unusual lattice of slender columns of bone termed trabeculae and in the spaces of the trabeculae red bone marrow can be found). Bones of made…

Osteoporosis Osteoporosis is a disease of bone that leads to an increased risk of fracture. In osteoporosis the bone mineral density (BMD) is reduced, bone microarchitecture is disrupted, and the amount and variety of non-collagenous proteins in bone is altered. Osteoporosis is defined by the World Health Organization (WHO) in women as a bone mineral density 2.5 standard deviations below peak bone mass (20-year-old healthy female average) as measured by DXA; the term "established osteoporosis" includes…

Osteoporosis: Bone Loss Osteoporosis is a detrimental bone condition, the tissue in the bones deteriorate and thus the bones become progressively brittle which presents a risk for rupture. Osteoporosis impacts more than 44 million Americans and is linked to a suggested 2 million bone fractures each year. According to the National Osteoporosis Foundation, the amount of fissures due to osteoporosis may escalate above 3 million by the year 2025. Osteoporosis is typically undetected and advances with…

Osteoporosis is a disease that results in the thinning of bones making them brittle which eventually lead to serious injuries in older adults. The disease falls into two categories, Type 1 Postmenopausal and Type 2 Age Related. Bone itself is a tissue comprised of calcium and collagen which provides our body with the resilient framework to carry on day to day activities. “More than 99% of the body’s calcium is contained in the bones and teeth, the remaining one percent is found in the blood.” (1)…

implications of bone remodeling as proposed by Svetalana V. Komarova, Robert J. Smith, S. Jeffrey Dixon, Stephan M Sims, and Lindi M. Wahl. Bone remodeling in the human body is an intricate process where osteoclasts resorb existing mineralized tissue and osteoblasts form new bone. Bone remodeling involves various interactions between different cells in the osteoclasts and osteoblasts. A problem occurs when these interactions are disturbed and can lead to numerous different bone disorders such as…

Osteoporosis is a disease that decreases bone mass and strength and causes bones to become fragile. Osteoporosis affects almost 10 million individuals in the United States, but only a small proportion are diagnosed and treated (Lindsay & Cosman, para.1). In the early 19th century, Astley Cooper recognized the link between fractures and bone density reduction due to aging. French pathologist, Jean Lobstein, was the first person to name the disease and describe the pathological appearance and condition…

over 50 US states have osteoporosis and low bone mass. “Studies suggest that approximately one in two women and up to one in four men age 50 and older will break a bone due to osteoporosis.” (NOF.org). Our bones are constantly being replaced with new tissue. Osteoporosis occurs when new bone is not replaced fast enough with the removal of old bone. Our bones can become very thin, brittle, and weak as you age which is why Osteoporosis is known as the silent thief. Most bone mass is reached by mid-twenties…

Osteoporosis develops when the remodeling cycle, which is when the disruption of the bone resorption and bone formation occurs. The imbalance of the remodeling cycle causes osteoporosis. Hormones, cytokines, and paracrine stromal-cell interactions affect the osteoclast’s processes, which includes proliferation, maturation, fusion and activation. The osteoclasts are controlled by the interaction between several interleukins, tumor necrosis factor, transforming growth factor-beta, prostaglandin E2…

Bone is a connecting tissue between muscles to support and protect all major internal organs of the body, also is a major store house for calcium in the human body. It is composed of elastic fibers known as collagen made up of protein material and calcium phosphate crystals in between the collagen fibers that will provide hardness and strength to framework of elastic fibers. This combination of calcium phosphate crystals and collagen fibers provides flexibility and hardness to bone, under stress…