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The Evolutionary Resistance Of Malaria

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Hussam Mahmood
Evolution Term Paper Draft

Evolutionary Resistance in Malaria As you calmly inch forward with a finger on the spray head, approaching steadily yet cautiously to avoid startling the organism who is miniscule compared to ourselves, one fails to take into account the broad consequences that their actions may have. This was a similar idea in the 1950s when cases of malaria arose and the most economical and effective means of control was essentially spraying at the touch of a button. Insecticides are a rapid way of killing mosquitoes that carried diseases. It was the clear solution to the problem; however mosquitoes evolved resistance to the insecticides. Since then, researchers and organizations have developed strategies to tackle the issue of insecticide resistance especially in the case of malaria. There have been tactics that have developed to hinder or prevent evolutionary resistance with the help of underlying evolutionary principles.
Evolutionary resistance was first seen after the initial malarial outbreak in the 20th century. At the time, eradication was the goal and so the World Health Organization launched a global program that treated patients with chloroquine and controlled mosquitoes with the insecticide DDT(Greenwood et al. 2008). This prolonged use of each treatment led to evolutionary resistance in both the disease and the vector to their respective antagonizing agents. More recently, a class of pyrethroid insecticides, consisting of four

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