The False Validity Of The Chemical Imbalance Myth

In just one theory, Burton believed that melancholy could be prevented with a sufficient sleep, music, healthy diet, and "consequential work", as well as having a balanced social life with friends and family. Moreover, in the period of 18th century, the theory of melancholia, which is linked to a Major Depressive Disorder, had become progressively more challenged by electrical and mechanical explanations; whereby, if a person exhibited a gloomy and dark state of mind it was also proved that the person gave way to a depleted state of energy loss (Girdlera & Klatzkinb, 2007).

Major depressive disorder is one of the most common mental disorders, with a 12-month prevalence of 6.7% of adults in the United States (NIMH). There is no definite etiology of depression, but several risk factors have been identified. Functional and structural changes in the brain have also been explored. The most common treatment for depression is the use of drugs that act on monoamine transmitters, including norepinephrine, dopamine, and serotonin. Decreases in these transmitters, especially serotonin, were hypothesized to play an important role in the cause of depression (Breedlove & Watson, 2013). The serotonin hypothesis led to the development of selective-serotonin reuptake inhibitors (SSRIs), which increase the amount of serotonin in the brain. Further research suggests that the serotonin hypothesis is not entirely accurate and the neurobiology of depression is much more complex. The “chemical imbalance” explanation of depression may not reflect the full range of causes and may be given greater credibility by patients and doctors than is supported by evidence based research.

One of the most common psychiatric disorders is known as clinical depression and affects anywhere between 3% and 13% of the population with some form of depressive symptoms affecting as much as 20% of the adult population at some point in their lives (Amenson & Lewinson, 1981; Kessler et al., 1994; Oliver & Simmons, 1985, as cited in Antonuccio, Danton, & DeNelsky, p. 574). The concept of ‘harmful dysfunction’ advanced by Horwitz and Wakefield (2007) describes two key components of clinical depression: a dysfunctional mechanism and the dysfunction being harmful to the individual (as cited in, Parker & Paterson, p.405). This paper explores the following questions: what does research indicate about clinical depression and what are the implications for treatment? Reviews are presented in regards to the emergence of depression and psychotherapy versus medication to treat clinical depression. Considerations are briefly discussed and the research paper will conclude with an interpretation of the critical points.

Major depression is a commonly diagnosed psychological disorder affecting individuals’ ability to feel happiness and peace of mind. Those who suffer experience negative emotions, lack of motivation, changes in behaviour and dysfunctional cognitive symptoms. Depression is classified by the Diagnostic and statistical manual of mental disorders Fifth Edition (DSM-5) as five of more of the listed symptoms present persistently over the same two weeks. One of these symptoms must be depressed mood or loss of interest in previously pleasurable activities. Depression causes disruption to typical daily life such as inability to maintain friendships and jobs. Other symptoms outlined by the DSM-5 include; insomnia, fatigue and recurrent thoughts of death. There is much debate over what exactly causes depression. Biological explanations question hereditary and neurotransmitter factors. While psychological theories include the cognitive ideas of Beck’s negative triad and hopelessness theory. This essay will focus on the ways in which psychological and biological explanations contrast and how their theories can overlap to better understand depression.

In today’s society, people are oriented to turn to medications and prescriptions to help with the battles between themselves and their emotions. Giles Fraser, author of “Taking Pills for Unhappiness Reinforces the Idea That Being Sad Is Not Human,” published in 2013 in the Guardian newspaper, argues that the general public is being erroneously treated with medications for conditions that do not exist, reinforcing that sadness is not natural. Fraser starts generating credibility by using data and statistics, and strengthens his appeal to ethos by mentioning his childhood, yet fails to connect with reader’s emotions by discrediting real medical conditions, all the while making a sound argument. Throughout the article, Fraser develops his credibility by connecting his ideas and claims with data and statistics, creating a strong argument. By incorporating statistics, Fraser promotes his credibility by showing that he is knowledgeable on the topic and that he has done his research.

The questions that are hoped to be answer by the end of this research are the following: what are the chances of overdosing while taking antidepressants? Is therapy more efficient than medication when treating patients that have been diagnosed with depression?What causes chemical imbalances? When can therapy or medication become the best option for treatment for depression? Where is the best place to get therapy or a prescription for depression? Who can help patients get better? How can therapy be more useful and more helpful than medication? Why are there not any more options for mental illnesses? Would doctors admit to their preferences of treatment when dealing with patients that have been diagnosed with depression? Could medication lead to suicide for depression diagnosed patients? Should medication be treated as the first option for treatment against

PSYCHOLOGY Custom Edition for Bergen Community College: (pages 150-151, chapter 4, altered states 4.7 & 4.8)

The cause of Clinical depression has long been a mystery to physicians and researchers. Many different theories have been proposed, but no conclusive evidence has been put forth. However, most of what we know about depression stems from the results of certain drugs which have been successful in treating the clinically depressed. These anti--depressants have led to the assumption that depression is most likely due to a chemical imbalance (of neurotransmitters) which somehow leads to the symptoms of depression. To try and write a paper on all the theories of depression would be endless, as would be a study on all the different types of

Psychological issues affect people with symptoms of depression and/or anxiety. Depression is a condition in which a person’s main emotions withdraw and there is a prolonged sadness over a long period of time. Main causes of depression consist of abuse in one’s lifetime, horrific or tragic events and or certain medications. “About 121 million people world-wide are believed to suffer from depression” (Naurt, 2008). Symptoms consist of low self esteem, disturbed sleep habits, appetite loss and the feeling of being not wanted; “It can lead to suicide and is associated with 1 million deaths a year” (Naurt, 2008). Antidepressants are the common treatment for depression, but music therapy is becoming increasingly popular. The biological perspective on the anti-depressants given to patients diagnosed with depression can have very horrific side effects. One such group of anti-depressants is Selective Serotonin Reuptake Inhibitors (SSRIs): “…there is also an established direct link between suicide and violent behavior and the use of SSRIs” (Tyrell, 2001). Most people stop using anti-depressants because of the drugs’ side effects. The SSRIs are just one example of malicious effects anti-depressant drugs that can create on people. Another research study completed by Kikuchi, Mimura, Suzuki, Uchida and Watanabe (2013), affirms their hypothesis that antidepressants has profound negative effects on patients with

Depression is a normal emotional reaction to perceived loss and hopelessness (Segal, Williams, & Teasdale, 2002). There are a number of different types of depression such as chronic depression, manic depression and the primary focus of this essay Major Depressive Disorder (MDD). MDD is a clinical depression, which is more chronic and more severe compared to other types of depression. It significantly disrupts the individual’s ability to meet the normal demands of life. According to many clinicians, clinical depression should be considered as a medical illness in need of medical intervention. Other mental health professionals believe this is an overstatement of the role of physiology and the

(3) While successful drug therapies which act on neurotransmitters in the brain imply that depression is a neurobiological condition (4), the fact that such medications do not help about 20 percent of depression-sufferers seems to show that not all depression is due to such imbalances. Rather, depression is not caused by one single factor; it is most often caused by many different things. Genetics, biochemical factors, medicines and alcohol, developmental and other external factors, and relationships, marriage and children all have effect on the development of clinical depression. (5) The strongest hypotheses on the pathways to depression are in decreases in the activity of specific neurotransmitters, or the overactivity of certain hormonal systems. (3)

“Eleven percent of Americans aged 12 years and over, take antidepressant medication,” “antidepressants were the third most common prescription drug … in 2005 – 2008,” and from 1988 to 2008, the rate of antidepressant use in the US increased nearly 400% (Pratt).

In total, the results of 1460 patients receiving antidepressant medication and 858 receiving a placebo sugar pill were analyzed. This analysis combined the results from these 19 different studies and generated an effect size (which is calculated as the mean of the experimental group minus the mean of the control group, divided by the pooled standard deviation SD). Once Kirsch and Sapirstein subtracted mean placebo response rates from mean drug response rates, they found a mean medication effect of 0.39 SDs (1). For each type of medication, the effect size for the active drug response to drug response is between 1.43 and 1.69, and the placebo response is between 74% and 76% of the active drug response. This means that 75% of the effect attributed to the perceived use of anti-depressants was due to the placebo. The perception of clinical benefit from antidepressants was largely attributed to the perceptions of the mind, and not to the actual chemical make-up of the pills patients were taking. The placebo effect shows us that the mind heavily influences our perceptions of wellness and health.

The severity of depression has been supported through scientific evidence that indicates that depression has a biological basis in the brain of a depressed person along with psychological and social implications. Whilst there are many catalysts in a person’s life that can be identified as a possible root cause of depression, such as stressful life events or the death of a loved one, the issue is far more complex, as the biological triggers of depression are not as easily expressed, such as faulty mood regulation in the brain, vulnerable genetics in the DNA, and other medical problems. Many things are altered in the brain of the depressed person. Firstly, what most understand to be an imbalance in the levels of chemicals that regulate emotions, is in reality far more elaborate. The true issue surrounding the many chemicals involved inside and outside of the nerve cells that undergo numerous chemical reaction which make up the dynamic system that is responsible for mood, perceptions, and the way one experiences life you experiences life can be altered in different ways that affect how one lives. Along with the brains chemicals, the connections between nerve cells called neurons decrease and deteriorate, meaning the

One of the scariest emotional experiences a person can ever suffer during their lifetime is to experience a form of depression. Over one in five Americans can expect to get some form of depression in their lifetime. Over one in twenty Americans have a depressive disorder every year. Depression is one of the most common and most serious mental health problems facing people today. However, depression is often not taken seriously because of the large use of antidepressant drugs and the large number of sufferers. Depression is a serious illness and should be taken as so. Contrary to the popular misconceptions about depression today, it is a serious and deadly disorder.1