The Five States of Chronic Kidney Disease

1790 Words Feb 26th, 2018 7 Pages
Kidney disease always being neglected as it was asymptomatic in the early stage. Chronic kidney disease was divided into 5 stages and according to its severity. The staging system is based on the estimated GFR and remaining kidney function. In each stages of chronic kidney disease, there is certain medical action and investigation need to be carry out to monitor the progression of disease. Medical practitioners can use this as basis guidelines to monitor the deterioration of kidney disease. Patient will increase severity of uremic and suffer from clinical manifestations of azotemia when GFR drop to less than 25% of normal (Schrier, 2010). When GFR drop to less than 15ml Stage 5 CKD patient need to be undergo renal replacement therapy, either dialysis or renal transplant in order to avoid complication such as uremic and fluid overload.

Whenever there is an injury occurs to the kidney, reduction of nephron number will be result from compensatory of glomerular haemodynamic changes. The remaining nephron will be undergoing a process call hypertrophy, with the increase in glomerular blood flow. Intraglomerular pressure and amount of filtrate formed by each single nephron rise. Angiotensin II being activated and cause the vasoconstrictor…

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