The Herpes Simplex Virus

1106 WordsJan 30, 20184 Pages
Herpes simplex virus (HSV) is a virus that affects many people in the world. This paper will discuss the history, taxonomy, structure, and replication of the virus. The common symptoms, treatments, and vaccinations will also be discussed. The herpes simplex virus was first mentioned as far back as 400 BC. Hippocrates wrote about symptoms of lesions. He used the word “heparin” which means to creep or to crawl. Between 14AD and 37AD Emperor Tiberius banned kissing from public festivals and ceremonies because he understood that the disease was passed from person to person. In 1893 Emile Vidal proved that the herpes simplex virus is transmitted from person to person. The virus was first isolated in 1925 by Frederic Parker and Robert N. Nye by growing the virus in vive using rabbit’s testis cells. The Herpes simplex virus is commonly known as just herpes. HSV is part of the family herpetoviridae and the genus simplexvirus. There are two strains of this virus: HSV1 known as the oral infection and HSV2 known as the genital infection. The structure of the virus is an enveloped, icosahedral capsid, and single linear double-stranded DNA. The capsid contains dsDNA, α and β proteins. The α proteins regulate the reproductive cycle and block the presentation of antigenic peptides on the host membrane. The β proteins are in charge of the viral nucleic acid metabolism and capsid proteins. The glycoprotein spikes are gB, gC, and gD. There are many modes of transmission of the virus like

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