The History Of Hemophilia A / B, Inheritance Patterns, And The Treatment Options

Hemophilia is an X-linked recessive disease in which blood lacks blood-clotting proteins. Females have two X chromosomes, indicating that they are generally carriers and transmit the gene to their sons. People with mild hemophilia bleed after surgery, injury, or trauma. Severe hemophilia produces spontaneous internal bleeding in joints and muscles. Fortunately, medicines and lifestyle changes offers hemophiliacs fairly normal lives. Through learning about hemophilia, I became interested in genetic diseases and finding a cure for those

A parent can pass the abnormal gene for the disease to his or her child. Most circumstances are "autosomal dominant inherited" disorders, which means a person only need an abnormal gene from one parent to be affected. If a person have the genetic factor for von Willebrand disease, an individual have a 50 percent chance of spreading this gene to their children. The harshest form of the ailment (type 3) is "autosomal recessive," which means both parents have to pass an abnormal gene to the young (National Hemophilia Foundation, n.d.).

As the best of my knowledge I believe the two year old child is suffering from an inherited disorder called hemophilia. The Mayo Clinic describes hemophilia as a rare blood disorder that lacks sufficient blood clotting proteins. (Staff, B.M. ((n.d.)). Hemophilia. Retrieved September 27, 2016, from http://www.mayoclinic.org/disease-conditions/hemophilia/basics/treatment/con-20029824

The genetic disorder of Hemophilia is where the clotting factors of the blood are absent or deficient, causing it to be a dangerous disorder to the people who have it. This disorder is where the people who have it will bleed easily and accessibly. Different types of hemophilia are classified by different deficient clotting factors in the blood. Treatments for hemophilia are available, including transfusions of frozen

According to the CDC website, Hemophilia, is a hereditary bleeding disorder which affects mostly males due to X chromosome singularity. Hemophilia is a medical condition in which the blood clotting becomes a challenge for those affected. Symptoms include spontaneous bleeding from injuries or surgery. Blood contains many proteins called clotting factors that assist in blood coagulation, however; those individuals with hemophilia have low levels of either factor VIII or factor IX. The severity of the condition is determined by the amount of factor in the blood thus the lower the amount of the factor, the higher the chances that spontaneous bleeding will occur leading to more severe health complications.

Haemophilia is a genetic disorder that is passed through generations on the x chromosomes, that affects the clotting factor in the blood and makes patients more prone to spontaneous and injury-resulted bleeding which is usually internal. According to the Haemophilia Foundation Australia (2015), there are over 3,000 cases of haemophilia in Australia, and more than half the cases are in males. The National Haemophilia Foundation (2013) website shows that cases of haemophilia go back to the 2n d century, where Jewish boys who have records of uncontrollable bleeding leading to death in their family do not have to undergo circumcision, also cases in 10th century Arabia show deaths of males after uncontrollable bleeding due to trauma. The first

Hemophilia is a rare disorder in which your blood doesn 't clot normally because it lacks sufficient blood-clotting proteins known as clotting factors. Hemophilia is an inherited (genetic) disorder. There 's no cure yet. But with proper treatment, most people with hemophilia can maintain an active, productive lifestyle. Hemophilia was recognized, though not named, in ancient times. The Talmud, a collection of Jewish Rabbinical writings from the 2nd century AD, stated that male babies did not have to be circumcised if two brothers had already died from the procedure.

Autosomal recessive inheritance implies that the quality is situated on a single autosome of the autosomes. This implies men and women are similarly influenced. "Recessive" implies that two duplicates of the gene are important to have the characteristic, one acquired from each parent. An individual who has only a single recessive gene is know a "carrier" for this gene or infection, yet they don't have any medical issues from "carrying" one duplicate of the gene. Majority of the individual are not aware that they are carry a heterozygous genetic factor for an illness until they have a baby with it. [1] When mother and father have had a child with a recessive trait or illness, there is a one out of four, or 25% chance, with each consequent pregnancy,

Because the genetic defect occurs on the X chromosome, women are carriers of hemophilia but rarely have the disorder. Hemophilia occurs almost exclusively in men.

A. It 's important to know that hemophilia is not actually a disease or virus. https://my.clevelandclinic.org calls hemophilia "a rare hereditary (inherited) bleeding disorder in which blood cannot clot normally at the site of a wound or injury". This means that it is not contagious, rather it is passed down through genetics. When a hemophiliac gets injured,

It all started when Queen Victoria of England took the throne. She passed the hemophilia gene down to the next generation of her children and grandchildren

There are many tests that help diagnose this disorder in a person. One of those is a screening test. Another test is clotting factor tests. On a normal basis, hemophilia is found in your genes when you are born. This disease can be treated in different ways. In my research, I found that you can replace the clotting factors in your blood. You would need to replace them because hemophilia comes from deficiency in you clotting factors. This disorder can be found

This research paper is about the various symptoms of hemophilia. The paper is going to outline and deeply describe the various ways that hemophilia manifests itself on patients. The paper also encompasses the factors that triggers the symptoms and the afterward effects on the individual. This paper will involve sourcing information from several books written by reputable authors and also getting information from the websites of highly recognized organizations as well as institutions. The paper will also rely on the recorded information from hospitals regarding the hemophiliac patients either a child born with the disorder or an adult who had reported the disease. The symptoms of hemophilia mainly manifest by the action of excessive bleeding which are normally spontaneous thus the paper will include all the abnormal instances of bleeding that are more or less the symptoms of hemophilia.

Nowadays, haemophilia is the most common blood clotting disorder among men. Since men have only on X chromosome, if they inherit the haemophilia gene, they will have haemophilia.

Occasionally a baby is born with this disorder and no family history of it. When this happens, it could be caused by a hidden gene, which is when several generations of female carry it, and it has not affected any male members of the family or a spontaneous mutation. With each pregnancy, a woman who is a carrier has a 25% possibility of having a son born with hemophilia. Since the father's X chromosome is what determines if the unborn child will be a girl, all of the daughters born of a man with hemophilia will be carriers. None of his sons, which is determined by the father through his Y chromosome, will have hemophilia. Individuals who suffer from mild hemophilia may choose to use a non-blood product known as Desmopressin acetate (DDAVP) to help treat the small bleeds and/or scrapes. For deep cuts or internal bleeding, the treatment called DDAVP may not be enough and therefore, may need a much more complex treatment. The clotting factor must be replenished so the affected person can form a clot to stop the bleeding. Plasma is one of the ‘human blood products’ than is used for factor replacement. Another factor replacement option is using the recombinant factor, which is produced in a laboratory.