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The History Of Thalidomide

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In the early 1950s, scientists at Chemie Grunenthal GmbH, a German pharmaceutical company developed a drug called Thalidomide. The drug was developed to treat respiratory infections and influenza however after getting minimal results they then decided to market the drug as a sleep aid and to treat morning sickness. Due to improper testing Thalidomide was released on the market and caused countless still births, miscarriages and tens of thousands of babies to be born with birth defects. (Lenz, 1988) This became the start of one of the world’s biggest pharmaceutical disasters. This essay will explore the history of Thalidomide and the effects it had on the human race. Through this I will show how bad science can be detrimental to society and …show more content…

Grunenthal began clinical trials to test Thalidomide’s effect as an anticonvulsant, anesthetic and spasmolytic. The test results showed it made the test subjects drowsy. In 1956 it was marketed as Grippex, designed to treat influenza. (Lenz 1988) Thalidomide was also tested on people with anxiety and suffering from stress. Grunenthal then remarketed the drug under the name Contergan in 1957 to reduce stress and as a sedative. (Mandal 2015) Although it was known that compounds could cause teratogen effects, it was not yet a law that all drugs must be tested on pregnant women or animals. Scientist at Grunenthal discovered that Thalidomide had similar chemical structures to popular sedatives Diazepam and Barbital. They performed clinical trials to confirm this. At this time extensive testing was not necessary to be performed on new drugs, “thalidomide had passed safety tests performed on animals. In some tests, dosages of over 600 times the normal human dosage had no effect at all on rodents” (BBC, 2014) these tests lead scientists to believe that Thalidomide was safe to use on humans, pregnant women inclusive, due to having an almost non existent toxicity level and the drug was released with only minor side effect warnings. Physicians across Germany recommended Thalidomide to women to treat morning sickness; this advice was wide spread across western Germany and eventually across the 46 countries that sold …show more content…

Firstly that society often blindly trusts big companies based on the belief that they only release drugs that are safe for consumers and are often swayed to believe these companies due to heavy amounts of advertising. Society trusts that all the harmful risks of medicines will be made apparent that were found through extensive research. Secondly, the horrific side affects that Thalidomide caused in pregnant women generations of people in up to 46 countries began to doubt pharmaceutical companies and manufacturers. This tragedy showed the importance of knowing all the risks of new drugs and medical treatments being proposed. Safety regulations for new drugs were improved all over the world to ensure adequate testing of new drugs and preventing the release of unsafe drugs. Finally though bad science allowed Thalidomide to be released onto the marked and deform more than 10,000 living babies, it created a positive change in the way we test our drugs and has prevented another instance like this from happening

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