In the early 1950s, scientists at Chemie Grunenthal GmbH, a German pharmaceutical company developed a drug called Thalidomide. The drug was developed to treat respiratory infections and influenza however after getting minimal results they then decided to market the drug as a sleep aid and to treat morning sickness. Due to improper testing Thalidomide was released on the market and caused countless still births, miscarriages and tens of thousands of babies to be born with birth defects. (Lenz, 1988) This became the start of one of the world’s biggest pharmaceutical disasters. This essay will explore the history of Thalidomide and the effects it had on the human race. Through this I will show how bad science can be detrimental to society and …show more content…
Grunenthal began clinical trials to test Thalidomide’s effect as an anticonvulsant, anesthetic and spasmolytic. The test results showed it made the test subjects drowsy. In 1956 it was marketed as Grippex, designed to treat influenza. (Lenz 1988) Thalidomide was also tested on people with anxiety and suffering from stress. Grunenthal then remarketed the drug under the name Contergan in 1957 to reduce stress and as a sedative. (Mandal 2015) Although it was known that compounds could cause teratogen effects, it was not yet a law that all drugs must be tested on pregnant women or animals. Scientist at Grunenthal discovered that Thalidomide had similar chemical structures to popular sedatives Diazepam and Barbital. They performed clinical trials to confirm this. At this time extensive testing was not necessary to be performed on new drugs, “thalidomide had passed safety tests performed on animals. In some tests, dosages of over 600 times the normal human dosage had no effect at all on rodents” (BBC, 2014) these tests lead scientists to believe that Thalidomide was safe to use on humans, pregnant women inclusive, due to having an almost non existent toxicity level and the drug was released with only minor side effect warnings. Physicians across Germany recommended Thalidomide to women to treat morning sickness; this advice was wide spread across western Germany and eventually across the 46 countries that sold …show more content…
Firstly that society often blindly trusts big companies based on the belief that they only release drugs that are safe for consumers and are often swayed to believe these companies due to heavy amounts of advertising. Society trusts that all the harmful risks of medicines will be made apparent that were found through extensive research. Secondly, the horrific side affects that Thalidomide caused in pregnant women generations of people in up to 46 countries began to doubt pharmaceutical companies and manufacturers. This tragedy showed the importance of knowing all the risks of new drugs and medical treatments being proposed. Safety regulations for new drugs were improved all over the world to ensure adequate testing of new drugs and preventing the release of unsafe drugs. Finally though bad science allowed Thalidomide to be released onto the marked and deform more than 10,000 living babies, it created a positive change in the way we test our drugs and has prevented another instance like this from happening
Clearly, these researchers had their own agenda to acquire a medical breakthrough that would change the history of science and contribute to the greater good of society. However, their authority was used in an unwarranted manner to accomplish their goals, regardless of their respectable intentions in wanting to make medical progress. In reviewing these researchers and medical practitioners’ actions during the 1950’s which entails series of unethical behaviors and violation of human right, it develops an essential need to establish guidelines in the attempt to protect patient’s rights and privacy. Furthermore, due to the alternatives that arise throughout this case, there are many possible outcomes to be considered that could have a significant impact on stakeholders if these courses of action are fallowed. These solutions consequences may involve the tentative research, an advance way of life for the Lack’s family, political turmoil, economic health impact and a society whose cells may have similar experience.
Through the ages, men have been able to find cures for catastrophic diseases through scientific research. Thanks to these advances, men have been able to prolong the life span of people, or provide better quality of life in cases in which a cure of various maladies has not been possible. To achieve such progresses, scientists have made use of prior knowledge, new theories, and technology obtaining numerous prodigious outcomes. Unfortunately, there have been many who have used questionable means for such ends. The German Max Clara is another case of a man with power and knowledge of science, who has misusing them. This paper aims to briefly identify principles and standards that would have been violated these days according to the existing APA Code of Ethics. Finally, ethical implications of making a moral judgment on past actions by researchers regarding human experimentation are discussed.
This section of Chalmers’ book makes the reader ponder the morality of medical experiments like abortions, stem cell research, and infanticide in the world today and questions whether we have learned from Nazi medical experiments in the past.
In Brave New World, developments in reproductive and psychological technology have redefined human nature. Bokanovskification, the drug Soma, and the Feelies have desensitized and changed the people’s values in this dystopia. Similar advances such as vitro fertilisation, surrogate motherhood, psychotropic drugs, and genetic engineering have also emerged in today’s society. Unlike the author of Sorry But Your Soul Just Die, I disagree that psychological drugs, stem cell research, and genetic engineering will send us into a dystopian society.
Issues have recently started developing around the drug since just a few years after it was put onto the market. Hundreds of people have died from taking the drug for the
Advances in biotechnology have important applications to the core demographic concerns of human reproduction, raising a number of ethical issues. In the debate over this issue Kass the President’s council on Bioethics, with other scientist are nearly silent. In a critical discussion, Kass insists that producing and influencing babies in bottles is a gateway to a Brave New World. It is a way to maintain the population and keep the society from going into a revolution. However, in order maintain stability we must suppress all new scientific inventions along with artistic expression. Scientific research endangers humanity which can possibly threaten social order, which is why it must strictly be limited. Kass emphasizing on the technology itself
The rise of medicalization has been affected by many social factors, and has caused a winning-and-losing situation for those caught in the middle. In Peter Conrad’s article The Shifting Engines of Medicalization, he explains how medicalization was constructed by three certain factors: first, the authority within the medical profession; second, the activities of social movements and interest groups; and third, the rise in behavioral pediatrics in terms of medical control of childhood diseases, and directed organizational professional activities (Conrad, 2005, p. 4). There have been debates that some things should no longer be treated as an illness in the medical sphere. Conrad explains how the pharmaceutical industries are more aggressive in promoting their products to physicians and to the public, which is empowered by the consumers becoming increasingly active in their demand for medical services and treatments (2005, p. 5, 9). Companies are marketing diseases (creating “epidemics” and drug scares within a society) and then selling the drugs to treat those diseases (Conrad, 2005, p. 6). Society and these companies make it seem as though these disorders and diseases can happen to anyone at any time.
The high prices set by pharmaceutical companies for drugs allows the companies to continue researching, developing, and producing new drugs. As new diseases are discovered, new medications must be discovered in order to treat them.
In general, with every pregnancy there is a 3-5% chance of having a baby with a birth defect. If a woman takes Thalidomide during her first trimester of pregnancy, the chance of her giving birth to a child with a birth defect increased to a 20%+ chance and the fetal and infant death rate is estimated to be 40% or more due to severe birth defects. (Thalidomide Side Effects on Babies). A portion of the children who suffer from birth defects caused by Thalidomide also suffer from developmental disabilities such as autism. Thalidomide victim survivors still suffer from these symptoms today. How does Thalidomide create all of these issues? The answer is science. The placenta is a very important organ that develops in the womb during pregnancy. The placenta nourishes the baby through through the umbilical cord and gets rid of all waste. The placenta is the first line of defense for the baby. It is a barrier that many harmful substances do not have the ability to cross. Before a pharmaceutical is offered to
From discussing Elvis Presley to Watergate, to AIDS the song touches on many happy events and many tragic events, like the Children of Thalidomide. All of them earning a spot in history forever. Thalidomide is a synthetic glutamic acid derivative that was synthesized in 1954, by Chemie Grunenthal under the brand name of Contergan. It was subsequently licensed in 46 other countries, covering all continents. It is an odourless white crystalline compound with low solubility in water.
In the late 1950s, the Thalidomide drug was used in Europe to treat morning sickness in pregnant women among other things. This study involved manufacturing company providing samples of this drug to physicians and compensating them to study the benefits and results of this drug. Although allegedly this drug did not cause any harm to the mother the fetus suffered severe damage as a result. There were thousands of children born with
The new miracle medicine fails to help society in the long run with the addition of a young and painful death for every human. The new medicine originally works as plan, with the first generation of users resistant to all diseases, however, their children suffer the consequences to this medicine. The new generations now need to fight for their lives just as they exit their adolescent years. The disease antidote seems like such a promising innovation, therefore, “no one could ever have anticipated the horrible aftermath of such a sturdy generation of children. While the first generation did, and still does thrive, something [goes]
Even though the pharmaceutical industry has made great improvements to human health and quality of life, like creating drugs for the treatment of AIDS, cancer, and other diseases, an increasing tension is growing between the public and the industry. These thoughts are fueled by issues such as drug pricing, affordable health care, and the battle against epidemic diseases in third world countries; social critics wonder whether this multi-billion dollar industry is giving enough back to the community and fulfilling its social responsibility.
Throughout the years a lot has evolved. Pharmacy plays a big role in all things changing. Medications are a necessity. It helps millions of people curing them of illnesses, it moderates pain, and it is a tool. In order for pharmacies to stay efficient and grow in efficiency things are constantly changing. For example, the Health Information Technology for Economic and Clinical Health Act (HITECH) was created as a step towards change. This legislation was created to be the beginning of the use of electronic health records. The CPOE is the computerized prescriber/ and or physician order entry. It helps hospitals and physicians offices use electronic health records in their practices and institutions.
There were two important developments in the 1970s which further shaped the industry in the form that we see today. Firstly, the Thalidomide tragedy (where an antiemetic given for morning sickness caused birth defects) led to much tighter regulatory controls on clinical trials, greatly increasing development costs. Secondly, enactment of legislation to set a fixed period on patent protection (typically 20 years from initial filing as a research discovery) led to the appearance of “generic” medicines. Generics medicines are those that have exactly the same active ingredients as the original brand, and compete on price.