The Human Body Transports Oxygen And Nutrients Throughout The Body Using The Vascular

1590 Words Dec 6th, 2015 7 Pages
The human body transports oxygen and nutrients throughout the body using the vascular system1. When a person acquires an injury that causes him/her to bleed, the body has a natural defense to repair it1; this is the basis of hemostasis, the formation and/or dissolution of blood clots2. Localizing and amplifying coagulation proteases and their subsequent cofactor complexes maintain hemostasis3. The inhibition and/or modification of these same coagulation proteases throughout the rest of the body, away from the trauma site, also helps to maintain hemostasis3.
Coagulation, a cascade system abundant in fibrin and thrombin proteins that are vital to hemostasis4, mainly occurs on the vascular surface because the rupture on the surface causes a successive activation of trypsin-like serine proteases which lead to the release of thrombin and clot formation3. The coagulation system may be activated via the intrinsic pathway, where plasma factor XII triggers coagulation to begin, or the extrinsic pathway, where thromboplastin released from tissues stimulates plasma factor VII –– once each pathway activates plasma factor X, a common pathway leads to the conversion of fibrinogen to fibrin4 (this conversion is a function of which thrombin is responsible for3). To prevent excessive bleeding (which occurs when there is a scarcity of thrombin5) and/or unwanted blood clots (which occurs when there is a plethora of thrombin5), coagulation must therefore be highly regulated3.
If hemostasis is…

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