The Human Genome : An Historical Record Of Endogenous Retroviruses

Viruses are microscopic particles that invade and take over both eukaryotic and prokaryotic cells. They consist of two structures, which are the nucleic acid and capsid. The nucleic acid contains all genetic material in the form of DNA or RNA, and is enclosed in the capsid, which is the protein coating that helps the virus attach to and penetrate the host cell. In some cases, certain viruses have a membrane surrounding the capsid, called an envelope. This structure allows viruses to become more stealthy and protected. There are two cycles in which a virus can go into: lytic and lysogenic. The lytic cycle consists of the virus attaching to a cell, injecting its DNA, and creating more viruses, which proceed to destroy the host. On the other hand, the lysogenic cycle includes the virus attaching to the cell, injecting its DNA, which combines with the cell’s DNA in order for it to become provirus. Then, the provirus DNA may eventually switch to the lytic cycle and destroy the host.

A retrovirus composed of DNA and RNA virus with the most complex replication, so it is different from a regular virus.

Humans were once infected by ancient viruses, but today, 8% of human DNA contains these ancient viruses

Most virus study is done with them as a pathogen, but there are a vast number of viral entities

This article covers the Seneca Valley Virus (SVV-001) as a hopeful for an oncolytic treatment of certain cancer types. More specifically those with neuroendocrine properties such as rhabdomyosarcoma, Wilms tumor, glioblastoma, neuroblastoma, and adult small-cell lung cancer. Each of which effect smooth/skeletal muscle cells, kidneys/adrenal glands (mainly in children), astrocytes of the brain, nerve cells of a fetus, and lung cells in adults respectively. The virus was discovered by accident in a contaminated cell culture that contained bovine serum to promote growth. The virus was later discovered to be almost exclusively found in farm animals such as cows and pigs, due to the presence of neutralizing antibodies that were later to only ever have been found in one human sample. Just as important as that, the virus only targets the cells of the above-mentioned cancers/tumors, is a self-replicating RNA virus, and its inability to infect other cells in the body all come together to result in the lysis of these specific cancer cells. These properties alone give great hope for SVV-001 as a treatment for those infected by these diseases, and prompted for more research into its medicinal possibilities.

viruses, and Herpes simplex viruses” (2). The primary virus used in gene therapy is the “adenoassociated

In the 1920's, HIV crossed from chimps to humans. There is evidence on how, when and where HIV first began to cause illness in humans. HIV is a type of lentivirus, which means it attacks the immune system. In a similar way, the Simian Immunodeficiency Virus (SIV) attacks the immune systems of monkeys and apes. There is even a theory on hunters, in the Democratic Republic of Congo eating monkey and transfer the virus. These well-known diseases, travel from Africa, Kinshasa to the United States. Started off being called GRID also known as gay-related immune deficiency introduced to united state in 1981. This disease has taken 121 healthy gay man lives in the U.S. since the mid-1970s. Scientists began to notice clusters of Kaposi's sarcoma and

Human herpes virus 8 (HHV8) was recently discovered in the tumours called Kaposi's Sarcoma (KS). These tumours are found in people with AIDS and are otherwise very rare. KS forms purplish tumours in the skin and other tissues of some people with AIDS. It is very difficult to treat with medication. HHV8 may also cause other cancers, including certain lymphomas (lymph node cancers) associated with AIDS. The fact that these cancers are caused by a virus may explain why they tend to occur in people with AIDS when their immune systems begin to fail. The discovery also provides new hope that specific treatments for these tumours will be developed that target the

There is still a great deal of information to learn from the study of viruses and the continued exploration of the viral genome is crucial in understanding how viruses communicate, transmit from host to host and evade immune responses. The ever-change nature of the viral genome has shown us that the most dangerous viral infections of today may be undermined by newer and more effective viruses, resulting in catastrophic outcomes. Through the study of viruses, it is the hope of the scientific community to be ahead of the viral curve, preventing infections before they even

The purpose of this study was to observe whether or not tripartite motif 5α (TRIM5α) proteins in Old World monkeys (OWM) can reduce replication done by herpes simplex virus (HSV) in human HeLa cells. The premise for this experimentation was that TRIM5α proteins from OWMs was known to block replication of human immunodeficiency virus (HIV) and other retroviruses.

Some viruses also have an outer bag of lipo-protein called an envelope. After a virus attaches to a living cell, it either enters the cell to release the genetic information, or, the virus injects the information through the cells outer lining. Thus changing the cells natural functions and forcing the cell to spend its energy to create copies of the virus. The cell will go on making copies of the virus until the cell is used up and dies. The virus then leaves the dead cell and invades a nearby cell and the process starts all over. There are five types of human herpes virus: Varicella zoster which causes chickenpox, Epstein Barr virus which causes infectious mononucleosis, cytomegalovirus which can cause cytomegalic inclusion disease in infants, and herpes simplex viruses 1 and 2.

Genetic engineering allows biologists to manipulate an organism's genomes by utilizing biotechnology (Moulton, 2004 ). The Talimogene Laherparepvec virus, otherwise known as T-vec, is an oncolytic virus. A oncolytic virus, is a virus that destroys cancerous cells. The T-vec virus has recently had successful results for treating melanoma cancer. The virus originated from the herpes simplex virus 1 and has been genetically altered to help destroy cancer cells.The virus gets injected into the lesions, lesions are areas on or in the body that have been damaged . Not only does the virus destroy cancer cells, it also activities the immune system to attack the cancer cells. Many changes were done to diminish the virus, expand the selective for the cancer cells, and release the cytokine. The modifications that were implanted in the virus were, HSV-1 strain (JS1) which is the DNA set of the herpes virus, that increases the death of the tumour cells. To delete ICP34.5, that stops the HSV infection in the cells that are not tumorous, and will provide selective tumour duplication. As Well as the deletion of ICP47 that allows antigen presentation, an antigen is a substance that helps enable an immune response. Placing in the US11 will

All retroviruses, including feline immunodeficiency virus (FIV) and human immunodeficiency virus (HIV), produce an enzyme, reverse transcriptase, which permits them to insert copies of their own genetic material into that of the cells they have infected.

Herpes simplex virus (HSV) is one of the most prevalent human viral infections worldwide. It belongs to the family Herpesviridae and is composed of linear double-stranded DNA surrounded by icosahedral capsid (Uyangaa et al., 2014). There are two types of herpes virus, namely HSV type 1 and type 2 (HSV-1 and HSV-2), which are the common cause of oral (cold sores) and genital herpes. The HSV infection is highly contagious and can be transferred from person to person through direct close contact. In immunocompromised individuals, HSV infection can lead to even more devastating diseases such as corneal blindness and encephalitis. The HSV is a successful pathogen of humans as, following the primary lesions, it establishes a lifelong latent infection in the sensory neurons (Melchjorsen et al, 2009).

These DNA viruses are able to replicate well in epithelial cells, also causing genitomucosal lesions or lesions associated with epidermodysplasia verucciformis (a rare and heritable genodermatosis).