The Immune System And Defense Responses Against The Disease Producing Organism

The immune system depends on the body’s structures to help it function. For instance, the skin acts as the “body’s first line of defense.” If a pathogen finds a breach in the skin barrier, it is the circulatory system that must now signal the immune system of the invader. Shortly after, white blood cells will be notified of the infection and will target and destroy the pathogen.

The innate immune system is effective to a certain degree. That said, if the environment is regulated then the body is less likely to get ill. Innate immunity is effective as once the patient matures his immune system will mature due to the B and T memory cells. The memory cells will help the body prepare for the virus once it has arrived. The memory cells will send specialised lymph nodes to the invading pathogen. The B and T memory cells are key to immunity of a virus.

The body’s protection against viruses, bacteria and other types of invasions is our immune system (Tortora, 2014).

These droplets enter the nasal cavity of a second host where small hairs and a mucus membrane are present. They trap microbes before they can penetrate further into the body; however some microbes evade capture and continue into the lower respiratory tract. The respiratory tract, consisting of mucus and ciliated epithelial cells, catches more foreign particles and sweeps them up and out towards the pharynx (see Figure 1), where it is swallowed in to the stomach. The gut flora within the stomach secretes chemicals such as lactic acid which lower the pH,

Answer: Innate immune system or nonspecific resistance is also known as first line of defense. It’s nonspecific that means not design to target any specific microorganisms. Response time for innate immune system is very quick compare to adaptive immune system. These infections inhibited by the substance that change the humoral or cellular component of the host that mediated non specific resistance. They are not specific means they provide protection against a spectrum of organism. And they are vitamin, minerals, fatty acid and microbial product. These substances are major part of our diet. We consume food and get from it. Diet has both

understood that the pathogens adapted to the immune system and were immune to its defenses so

The organs that make up the lymphatic and immune system are the tonsils, spleen, thymus gland, lymph nodes, and lymphatic vessels. White blood cells (leukocytes), red blood cells (erythrocytes), plasma, and platelets (thrombocytes) make up the blood. Lymphocytes are leukocytes (white blood cells) that help the body fight off diseases. Two types of lymphocytes are B cells and T cells. Lymphocytes recognize antigens, or foreign substances/matter, in the body. Lymphocytes are a classification of agranulocytes, or cells (-cytes) without (a-) granules (granul/o) in the cytoplasm. B cells are created from stem cells, which are located in the bone marrow. B cells respond to antigens by becoming plasma cells. These plasma cells then create antibodies. Memory B cells produce a stronger response with the next exposure to the antigen. B cells fight off infection and bacteria while T cells defend against viruses and cancer cells. A hormone created by the thymus gland called thymosin changes lymphocytes into T cells. The thymus gland is active when you are a child and slowly shrinks, as you get older. T cells bind to the antigens on the cells and directly attack them. T cells secrete lymphokines that increase T cell production and directly kill cells with antigens. There are three types of T cells: cytotoxic T cells, helper T cells, and memory T cells.

Non-specific resistance, to an invading organism, or pathogen, is a defence mechanism the body employs to protect itself from attack (Tortora and Grabowski 1996). Inflammation, response to bacterial invasion, occurs due to release of chemicals in the bloodstream

The immune system can be branched into two functional categories- innate and acquired. Innate immunity is largely unspecific. The skin acts as a physical barrier; phagocytic cells recognize molecular patterns on pathogens and engulf them; the acidity of gastric juices kills microbes that are ingested through food; hair and mucus in nostrils traps microbes coming through the air; other secretions like saliva, tears contain anti-microbial enzymes to fight off potential invaders.

Physical and Chemical Barriers; Hair within the nose filters air containing dust. Despite these barriers, pathogens may enter the body through skin abrasions or punctures, or by collecting on mucosal surfaces in large numbers that overcome the mucus or cilia. Some pathogens have evolved specific mechanisms that allow them to overcome physical and chemical barriers. Nonspecific Resistance; the saliva thins the microorganisms and washes the mouth. Other parts of nonspecific resistance are the skin and mucous membranes,

The body’s immune system is the next specific response to pathogens being detected in the body. The response includes B and T Lymphocytes

If a pathogen breaches barriers: innate immune response result into an immediate effect of non- specific response. All Innate immune systems derived from plants and animals, when a pathogen evades the innate response, a third layer of protection is possessed by vertebrates in which activation of adaptive immune system takes place. The immune system response adopts itself within an infection and pathogen recognition is improved. As a result of the improved response, its then retains itself when the pathogen is eliminated in form of an immunological memory and allows the adaptive immune system to mount faster and stronger when pathogen is encountered each time.

Have you ever wondered how your body works? Did you ever think about how your body defends itself from outside invaders? Remember the last time you were sick. Did you know how your body fought and killed the sickness? All these questions can be answered by learning about one of the most important systems in your body, the immune system.

In this study, the CRPV/HLA-A2.1 transgenic rabbit model was used to assess the protective immunity generated by DNA vaccines delivered using the gene gun, the tattoo gun or the microneedle system. The focus was to determine whether the tattoo gun and the microneedle delivery systems were useful DNA vaccination alternatives to the gene gun. Our laboratory has successfully utilized the gene gun in our DNA vaccination studies for both protective and therapeutic purposes (17,34). However, the gene gun system is costly, and we are constantly looking for alternatives to back up our vaccine development program. Tattoo gun has been reported to deliver a DNA vaccine successfully in both mice and non-human primates (21-23). Compared with the gene gun and microneedle, tattoo gun delivery is more cost effective but more invasive which generates trauma and scars the vaccinated tissues. Microneedle delivery has achieved comparable protection in mice with twice the dose of gene gun delivery (24 ). However, no studies have been attempted in rabbits for DNA vaccination with either a tattoo gun or a microneedle. In the current study, we compared the gene gun with the tattoo gun as well as the tattoo gun with microneedle DNA vaccine delivery using our well-studied DNA epitope vaccines and our unique HLA-A2.1 transgenic rabbit model (39). Read out was tumor outgrowth rates and tumor size. We demonstrated that these two novel DNA delivery systems can be used for DNA vaccination in the rabbit

Our immune system is the second most complex system in our body. It is made up of organs, cells and proteins that work together to protect our bodies from harmful bacteria, viruses or other microorganisms that can cause diseases. Usually we don’t notice our immune system defending us against pathogens, but if the pathogen (harmful microorganism) is aggressive or if our body hasn’t ever come into contact with it, we can get sick. The jobs of our immune system are to recognise pathogens, as well as neutralise and remove them from our body. Our immune system also has to fight our own cells if they have changed due to an illness, for example, cancer. (1)