The Importance Of Folate As A Water Soluble B Vitamin

13. The effect on the folate concentration was that the exposed group again had lower levels then the non-exposed group.

22. All of the following types of drugs can interfere with the body's use of folate EXCEPT:

4. Vitamin K- Exists is several forms, resistant to heat but destroyed by acids, bases, and light, stored in liver. Functions: Requires for synthesis of prothombin, which functions in blood clotting. Sources: Leafy green vegetables, egg yolk, pork liver, soy oil, tomatoes, cauliflower. Excesses: jaundice in formula-fed newborns. Deficiencies: prolonged

In Canada, a clinical study by De Wals et al was performed to assess whether or not folic acid fortification has an effect on the recurrence of NTDs (neural tube defects), especially on upper and lower birth defects called spina bifida (De Wals et al., 2008). The study was performed in three different regions in Canada: the eastern, western and central provinces (De Wals et al., 2008). Furthermore, the population of the study was conducted on three different types of births which were livebirths, stillbirths, and termination of pregnancies, and the study was carried out through three periods included prefortification, partial fortification and full fortifications (De Wals et al., 2008). The researchers followed the scientific investigation

However, absorption cannot occur in the absence of IF. Once in the circulation B12 binds to a transport protein and is taken to the liver, bone marrow, and other proliferating cells. Most individuals with normal absorption have no issue acquiring the needed daily amount. The cause of Malabsorption of both folate and B12 is from lack of IF, gastric surgery, inflammatory bowel disease, celiac disease, and hyperthyroidism (Buttaro, Trybulski, Polgar Bailey, Sandberg-Cook, 2013). Healthy adults may consider taking supplemental crystalline vitamin B12 (Stabler, 2013). However, treatment is not necessary for asymptomatic anemia. Deficiency related to IF indicates a need for 1000 mcg of B12 intramuscular injections weekly for eight weeks and then monthly for life. Treatment for macrocytic anemia resulting from folate insufficiency is 1 mg of folic acid PO daily until the patient achieves an adequate hemoglobin level and indefinitely if patient has an underlying illness or an inadequate diet (Buttaro, Trybulski, Polgar Bailey, Sandberg-Cook,

Deficiency of the micronutrient folate continues to significantly affect the health of pregnant women and their children, globally. A great cause of concern with folate deficiency is the occurrence of Neural Tube Defects (NTDs) in new-born babies due to abnormal early foetal development. According to Greene et al. (2016), NTDs are abnormalities to the formation of the brain, spinal cord or related structures from early foetal development. The rate of the prevalence of NTDs varies between countries from 0.3 to 199.4 cases per 10,000 births. In Australia specifically, approximately 19.5 cases of NTDs occurred per 10,000 cases between 2009 and 2010 (Zaganjoy et al.,

1992, the U.S. Public Health Service recommended that all women who are in child bearing age consume at least 400mg of folic acid every day. Studies have shown that women who consume appropriate amounts of folic acid than their daily diets can decrease the possibility of their child being born with spina bifidia by fifty to seventy percent. The U.S. Public

Foods with Folate: Foods sure as oranges, fortified cereals, asparagus, beans and nuts are rich in folate. For women, folate is very important during pregnancy as it ensure proper neural tube development of the fetus. Plus folate help in the health of the heart. Recommended about is (RDA) 400 micrograms (mcg) per day.

Folic acid plays many important roles in the body. There is no doubting that it is essential. The reason that we need a constant stream of it is because it is not stored in large quantities in the body. It is water soluble. Fat soluble vitamins are stored for longer in our system. When ingested, the body uses what it can and the rest comes out in urine, in very little time the body will need more. We discussed how pregnant women get a proven benefit, and studies continue on its role in reducing risks of other diseases, but regardless of what additional benefits are found, it is clear that without folic acid in our bodies, we would not be alive. Folic acid aids in the production of red blood cells and the synthesis of DNA and RNA. Folate even has a role in the digestive system! It works with vitamins B12 and C to help the body digest and synthesize proteins. Lastly, folic acid helps tissues grow and cells function, it is an integral part of the body working as it should.

The MTHFR gene supply instructions for making an enzyme known as methylenetetrahydrofolate reductase. This enzyme function a role in processing amino acids, the building blocks of proteins. Methylenetetrahydrofolate reductase is substantial for a chemical reaction involving forms of the vitamin folate (vitamin B9) .Precisely, this enzyme converts a molecule called 5,10-methylenetetrahydrofolate to a molecule called as 5-methyltetrahydrofolate. This reaction is desired for the multistep procudure that converts the amino acid homocysteine to another amino acid, methionine. The body uses methionine to make proteins and other important compounds.

• nutrition B9, which may also be referred to as folic acid is determined in inexperienced leafy veggies and it's greatly fundamental for healthful DNA synthesis.

Pregnancy has always been an important time during any woman’s life, bringing a new life into the world is a blessing. While on the other hand, complications during pregnancies are the last thing anyone wants to hear or go through. One major complication that can occur during pregnancy is known as a neural tube defect, which is caused from a deficiency of folic acid over a specific period of time usually during the first few months of pregnancy. Throughout this paper I will talk to you about why neural tube defects are a growing concern, folic acids role in controlling neural tube defects, and also the amount of

In Australia, the reasonableness and effectiveness of folic acid being mandatorily fortified to support healthy pregnancy when considering the occurrence of NTDS in Australian children due to the amount their mothers have consumed of folic acid during pregnancy. The main purpose for creating a mandatory policy to include folic acid to the wheat flour of non-organic bread in Australia is to reduce the incidence of NTDs across the nation. Substantial rates of NTDs occur worldwide as significantly more folate is needed early in pregnancy than in other life stages. This early stage of pregnancy is often when women are unaware that they are pregnant. The folate is required for the development of the embryonic neural tube, which develops into

Unexplained fatigue, brittle, dry hair, ridged or spoon shaped nails, mouth problems, diarrhea, irritability or lack or appetite can all indicate nutrient deficiencies

Folate is a natural occurrence in foods such as beans and pulses (e.g. lentils and chickpeas), leafy green vegetables, broccoli, spinach, tuna and oranges (Tiran, 2000). Some foods are also fortified with folic acid such as cereals and bread. Late in the 1990’s United State scientists came to the realisation that despite the availability of folic acid in supplements as well as foods available in the supermarkets, people were still finding it a challenge to meet their daily folate requirement; with this in mind the United States of America implemented the folate fortification program (Latimes.com). For women of childbearing age, folic acid consumption needed to be increased so in January of 1998 the United States food and drug administration authorised a folic acid fortification of all products containing grain. The