The Importance Of Metabolic Syndrome

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Metabolic syndrome is a group of disorders that associated with high blood pressure, increased blood sugar, abnormal adipose deposition, and abnormal cholesterol or triglyceride levels. It is clear that with increasing rates of obesity the disease can begin at different ages and can extremely increase in childhood and adolescent. One of the most important complications of metabolic syndrome is cardiovascular disorders (CVDs). The latest report of the World Health Organization has shown that cardiovascular disease remains the first cause of death in the world. Approximately 17 million deaths, occurred in 2011, caused by CVD which means that one of every three people has died due to cardiovascular disease. It is possible to prevent or delay metabolic syndrome complications. However successfully controlling requires a long-term effort.…show more content…
Stimulating the cyclooxygenase 2 (COX-2) up-regulates PGI2 formation. Deletion of the PGI2 receptor removed the atheroprotective effect of estrogen. An increased risk of cardiovascular events has been associated with the use of COX-2 selective inhibitors. Cox-2 gene is expressed on both endothelial and macrophage cells and activation of this gene increases prostaglandins production especially PGI2, which prevents the formation of atherosclerotic plaques. Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases which are involved in the pathophysiology of metabolic syndrome. Metabolic syndrome is associated with elevated serum levels of MMP9 and MMPs play a key role in increasing cardiovascular risk of metabolic
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