The Importance Of Protein Degradation

In times past many people thought that memory loss was a normal occurrence for elderly people. This thinking was major reason for why Alzheimer’s disease was not caught until very later in the stages. Alzheimer’s disease is not a normal part of aging. After heart disease, cancer, and strokes, Alzheimer’s is the most common cause of death in adults in the Western world. “It is estimated that 4.5 million Americans over the age of 65 are affected with this condition. After the age of 65, the incidence of the disease doubles every five years and, by age 85, it will affect nearly half of the population” (Robinson).

“Alzheimer's disease is a progressive, degenerative disorder that attacks the brain's nerve cells, or neurons, resulting in loss of memory, thinking and language skills, and behavioral changes. These neurons, which produce the brain chemical, or neurotransmitter, acetylcholine, break connections with other nerve cells and ultimately die. For example, short-term memory fails when Alzheimer's disease first destroys nerve cells in the hippocampus” (Alzheimer’s Association Foundation.) The destruction of the hippocampus is very serious because the hippocampus is a structure in the brain’s limbic system that plays an important part role in memory (Ettinger 91.) Its is responsible for forming organizing and storing memories.It connects the memories to structures and senses like smell and sound. “The hippocampus is a horseshoe shaped paired structure, with one hippocampus located in the left brain hemisphere and the other in the right hemisphere. The hippocampus acts as a

Proteins are the metabolic workhorses of the cell; they engage in a variety of essential activities ranging from enzymatically catabolizing macromolecular food sources to serving as structural components that maintain cell stability. Maximizing protein function relies on intricate non-covalent interactions occurring on the secondary, tertiary, and quaternary levels that help determine the overall shape of the protein. In their native states, proteins will assume the most energetically favorable configuration. Occasionally however, cells are exposed to exogenous disruptions such as heat stress. Heat Stress can compromise protein three-dimensional structure. Hydrophobic residues tend to be buried in the interior of the protein but when

Alzheimer’s disease is the progressive loss of memory and mental functions. The disease affects memory, thought control, language, and other cognitive functions. The disease typically appears with old age and is often found age 60. Alzheimer’s causes the brain to develop clumps and tangles fibers in the brain tissue along with the loss of neuron connections. Throughout the brain, proteins are abnormally distributed and they form tangled bundles of fibers and amyloid plaques. Some neurons fail to function properly and lose their connections, which are necessary for the transmission of messages to the body. The hippocampus is the key brain structure in the formation of memories and often experiences the first signs of damage.

Since it is close structurally to the hippocampus, the amygdala is involved in controlling memory consolidation, especially emotional memories; when a memory is emotionally charged, it has a better retention rate than one that is not. The hippocampus is generally seen as having an essential role in the creation of new memories about past experiences; it's even responsible for memories that can be verbalized also known as declarative memory. Damage to it result in difficulties in forming new memories and being able to access new memories formed before the

Among these different processes are encoding, storage, consolidation, and retrieval. This study hypothesized that the hippocampus plays a different role in each of these. The method of this study is especially unique because it used temporary chemical inactivation of the hippocampus, which had not been done before. This temporary inactivation is unique because it lets the researchers selectively assess the role of the hippocampus during each of the processes discussed above. To test encoding, the inactivation occurred during learning of a maze task; to test retrieval, inactivation occurred during a retention task. Results indicate the temporary inactivation of the hippocampus impairs both encoding and retrieval. To test long-term consolidation, rats were trained and then separate groups received hippocampal treatment for different amounts of time between one and five days. Results showed that temporary inactivation during this time period disrupts memory for the already learned task. This study partially supports the result of the study by Eldridge et al. (2000) in that they both show the hippocampus is necessary for memory retrieval. However, it does not address the retrieval of different types of memory. This study also supports the idea from Wang et al. (2012) that the hippocampus may be involved in consolidation and storage of new memories but not necessarily of older

What begins with the withering of the memory with time the brain shrinks in such drastic and distressing fashion that nearly all functions become impacted. Shrinking takes place in the cerebral cortex (cerebrum’s outer layer), which damages such cognitive functions as remembering, thinking, and planning. Moreover, there is significant shrinkage of the hippocampus (small area of the cortex); thus, impacting the formation of new memories (Alzheimer’s Association, 2014). Further complicating normal functioning of the brain and tied to AD are amyloid plaques (protein fragment clusters), neurofibrillary tangles (twisted bundles of dead and dying nerve cells) and lost neuron connections (National Institutes of Health, n.d.).

Scientists found that individuals who kept their brains lively had decreased levels of this protein. Older people with the highest level of brain activity had protein levels equal to those of young people. Those with the lowest levels of brain activity had levels equivalent with Alzheimer’s patients. “Individuals with high cognitive engagement may prevent or slow the deposition of the protein fragments, which influences the progression of Alzheimer’s” (qtd. in Hope). Those who were cognitively active were two times less likely to develop this disease than those who got minimal mental stimulation. Mental stimulation includes games and puzzles such as sudoku which may improve the brain’s ability to remember and retrieve information. Researchers claim that keeping the brain active with reading, writing and crosswords could also help prevent this disease. All learning is based on what is already known, or an association to what is already known. When learning something new, synapses are made which are connections between nerve cells in the brain. Due to this, new synapses are not just being made, but the ones that are already there are being strengthened. Staying busy and socializing with friends and loved ones keep memory sharp by helping maintain the brain’s health and boosting its memory. Mental

Hippocampus is a small, curved region, which exists in both hemispheres of the brain and plays a vital role in emotions, learning and acquisition of new information. It also contributes majorly to long term memory, which is permanent information stored in the brain. Although long term memory is the last information that can be forgotten, its impairment has become very common nowadays. The dysfunction is exemplified by many neurological disorders such as amnesia. There are two types of amnesia, anterograde and retrograde. Anterograde amnesia is inability in forming new information, while retrograde refers to the loss of the past memory. As suggested by Cipolotti and Bird (2006), hippocampus’s lesions are

After a new memory is learnt, it enters the process of encoding during which the memory is labile and capable of disruption until it becomes stabilised over a period of time (Nader & Einarsson, 2010; Nader et al, 2000). This process is called consolidation and originally consisted of the theory that once stabilised in the brain, it remains fixed (Suzuki et al, 2004). This theory has been rebutted by the acceptance of reconsolidation, a theory that imposes the ideology that when memories are retrieved, through similar experiences (Lee, 2009), they become labile until,

Doctors and scientists dispute the exact role of the hippocampus, but agree that it has an essential role in the formation of new memories about personally experienced events. Some researchers prefer to consider the hippocampus as part of a larger medial temporal lobe memory system responsible for declarative memory. When a long-term, declarative memory is made, certain neuronal connections in the temporal lobe are strengthened, and others are weakened. These changes are fairly permanent, however some may take weeks or months before they are complete

for the Neurobiology of Learning and Memory at UC Irvine, California. They conducted a study where a

To understand the cognitive changes, they further used contextual fear conditioning and radial arm water maze paradigms (RAWM) to study aging effect to hippocampus related learning and memory. Mice injected with young plasma had increased freezing response in contextual, but not cued, learning and showed significant improvement on fear memory. They also exhibited enhancement in learning and memory in finding hidden platform location. On the other hand, no change was observed for aged mice and aged mice injected with aged plasma. Interestingly, these effects were reduced by heat denaturation. Thus, the heat-labile factors from young blood may rejuvenate cognitive ability for the aged mice.

Without the hippocampus, the information from the short-term memory (STM) cannot be stored in long term memory (LTM). The hippocampus is a very important part of the human brain to store our memories. If we lost it, we will lose all our conscious memories. From Henry’s case, it also discovered that there are multiple memory storage areas located at different parts of the brain while the hippocampus is important to consolidate short-term memory to long-term memory. The removal of hippocampus caused Henry to suffer until he died as he lost the ability to make new conscious