The Importance Of Zinc Deficiency For Human Health

Chronic intake, the delayed onset of action, drug resistance and numerous side effects force the researchers to look for the new, safe antidepressant strategies (1, 2) with rapid onset and longer time of action.

From the electronic database searches, several articles were appropriate. The first, "Vitamin D deficiency and depression in adults: systematic review and meta-analysis", was designed to find a relationship between Vitamin D and depression (Anglin, Samaan, Walter, & McDonald, 2013). Although, limited by the lack of random control trials, the data was presented in a uniform and consistent manner (Anglin et al., 2013). The results were in line with their goal, finding that low Vitamin D levels did correlate with increased depression (Anglin et al., 2013). Second, Meehan, and Penckofer, provided their inductive, exploratory opinion of "The role of Vitamin D in the aging adult" (2014). Although, the study was short and depression symptoms were self-reported, it, nevertheless, showed a correlation between low levels of Vitamin D and depression symptoms (Meehan, & Penckofer, 2014). The third article, "Vitamin D supplementation to prevent

Some of the most common antidepressants include Prozac, Celexa, Zoloft, Paxil, Remeron and Effexor, these come capsules or tablets, studies show that the effects of these drugs can include: Nervousness and anxiety, Insomnia, Irritability, Violent thoughts and actions, Agitation, Hostility, Suicidal thoughts or suicide, Tremors, Irregular heartbeat, Aggression, Confusion and incoherent thoughts, Paranoia, Hallucinations, Psychosis,

Zinc is an essential mineral, it is either added or naturally present in foods. You can find since added in many cold lozenges and a few over the counter cold remedies. There are numerous aspects of cellular activity that zinc is apart of. A few examples would be protein synthesis, wound healing, DNA synthesis, and cell division. While Zinc can also support a normal growth and development for women during pregnancy, as well as a child and adolescence. A daily intake of zinc is needed in order to maintain since the body has no specialized zinc storage system. To determine the proper intake recommendations of Zinc, using the Dietary Reference Intakes can help determine the right amount.

The body of an adult human contains almost 2-3 g of zinc. However, only 0,1% of it is found in the serum. As for other transition metals, circulating zinc is not free, but is complexed to proteins that maintain it in a non-reactive form in order to prevent their toxicity: almost 80% is bound to albumin and the remaining 20% is bound to α2-macroglobulin (Kambe et al., 2015). As zinc is required for many functions in living organisms, its transport across biological membranes is mediated by several proteins that can be classified in two major families of transporters: the SLC39 (Zrt-Irt-related Proteins, ZIPs) family, with 13 members identified, and the SLC30 (Zn-transporters, ZnTs) family, with 10 members (Fukada et al., 2011; Kambe et al.,

Zinc plays important roles in the functioning and homeostasis of the normal prostate, being a major constituent of it and having a concentration three to 10-fold higher than other soft tissues. (2).

The body also needs zinc to make proteins and DNA, the genetic material in all cells

The most common explanation for mental disorders is a chemical imbalance in the brain, but how and why these imbalances happen is not yet known. Since a complex web of nutrients, such as zinc, vitamin B6, and vitamin B12, are the building blocks that the brain needs to make the

It is hard to distinguish in human trials whether a zinc deficiency is the cause of depressive symptoms or if it is a result of the onset of the illness itself. It is likely that one is not consuming the appropriate nutrients when he or she is depressed. It was shown however, in

Zinc has an atomic structure of 4 levels. As shown above, these are the 4 shells. The four levels display their individual energy, overall adding up to the atomic number of 30. This can be seen below.

Zinc lack has been known to bring about balding and poor scalp conditions, and clams are stacked with zinc—only three ounces contains 493-percent of your day by day esteem. Be that as it may, an extraordinary shellfish will do: Steer clear of the ones got in the Gulf of Mexico, which may contain surprisingly elevated amounts of Cadmium due to the 2010 BP oil

Benzodiazepines are also commonly used adjunctively with SSRIs, and many clinicians believe that they provide benefits in terms of both speed of response as well as an overall response (Lader, 2011). In large part, the problem is that at a 3 to 4-week point, the patient typically feels better, has improved sleep, and attributes. The improvement to the benzodiazepines and not the SSRI (Lader, 2011). The chronic use of Benzodiazepines has become a problem in different countries such as Europe for the way they were being used. According to Bernardy (2012), the research noted that the number of Veterans being treated for PTSD in the

Zinc, a common mineral located on the periodic table, plays a significant role in how our bodies function. Found in different foods like meats, nuts, dairy products and certain vegetables; Zinc is an essential nutrient that the body needs on a regular basis. The RDA (Recommended Daily Allowance) of Zinc for adult males is 11mg per day and 8mg per day for females. A daily intake of zinc is recommended because the body does not have a specific way to store it. Besides not having a way to store Zinc, it can be found in the majority of all tissues in the body. Zinc functions as a cofactor to more than 300 different enzymes specifically regarding the human metabolism and its functions. Some of the specific functions that zinc is apart of in the

The CPZ-fed mice showed poor motor coordination in a rota-rod analysis [14] and a murine motor test [22]. In the 3rd and 4th weeks after consuming CPZ-containing diet, mice exhibited an increase in CNS activity. Moreover, mice displayed prepulse inhibition deficits during the 2nd and 3rd weeks of CPZ exposure period and showed less social interaction after CPZ exposure for 4–6 weeks [25, 44]. The CPZ-fed mice also showed spatial working memory impairment [25, 39, 44]. CPZ-induced demyelination and behavioral changes were also seen in rats [16, 18, 34]. These previous studies reminded us of an emerging hypothesis that oligodendroglial dysfunction and even death, with subsequent abnormalities in myelin maintenance and repair, contribute to the schizophrenic syndrome [10].

Interestingly, both tricyclic and SSRI antidepressant drugs commonly used to treat depression reverse the behavioral changes induced by ZnD indicating the feasibility of ZnD animal models in the study of depression.