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The Incidence Of Aki Between Two Perioperative Antibiotic Prophylaxis Of Elective Hip And Knee Replacements

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Anecdotal evidence suggested an increase incidence of AKI when gentamicin was used in combination with cefazolin and vancomycin for perioperative prophylaxis of elective hip and knee replacements. As post-operative AKI is associated with increased morbidity and mortality, the aim of this study was to compare the incidence of AKI between two perioperative antibiotic regimens in patients undergoing total hip arthroplasty (THA) and total knee arthroplasty (TKA).

Methods
This was a retrospective cohort that evaluated 300 patients who underwent elective hip or knee replacements that received cefazolin, vancomycin and gentamicin or cefazolin and vancomycin for perioperative antibiotic prophylaxis. The RIFLE classification was utilized to …show more content…

There was no significant difference in rates of PJI, CDAD, length of stay, need for acute hemodialysis, or readmission related to AKI.

Background

There were more than 1,000,000 total hip and knee replacements in the United States in 2010.1 Prosthetic joint infections (PJIs) are a rare complication of joint replacements, estimated to be less than 2% of cases, but result in significant morbidity and increased healthcare costs.2 Frequently, PJI requires removal of the prosthesis and a prolonged course of IV antibiotics. It has been estimated that the cost of one PJI is approximately $100,000 after a hip arthroplasty and $60,000 after a knee arthroplasty.2 Perioperative prophylactic antibiotics for total joint replacements have been proven to reduce rates of surgical site infections.2-3 It is recommended that prophylactic antibiotics are administered within one hour prior to surgical incision and are discontinued within 24 hours following the end of surgery.4 First generation cephalosporins, such as cefazolin, are the agents most commonly utilized for antimicrobial prophylaxis in joint replacement procedures.2,5 Vancomycin may be used in addition to a first generation cephalosporin in institutions considered to have a high rate of methicillin-resistant staphylococcus aureus (MRSA) surgical site infections. 2 If there is local data to suggest gram-negative pathogens as a cause of PJI then it is recommended to consider the addition

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