The Link Between Autistic Spectrum Disorder

Alzheimer 's disease (AD) was discovered by a German doctor Alois Alzheimer in 1906 when he found amyloid plaques and neurofibrillary tangles in the autopsy of a woman who died of an unknown mental disease. The extracellular amyloid plaque deposits, composed of insoluble amyloid-Beta peptide were hypothesized to be the main etiological factor. “The most important abnormality is an excess of Amyloid-beta peptides brought about through either overproduction or failure in degradation.” (Uzun, Kozumplik, & Folnegović-Smalc, 2011) Later, it was discovered that intracellular neurofibrillary tangles composed of hyper-phosphorylated, helically-paired tau

Autism Spectrum Disorder is defined as a neurodevelopmental condition that is classified by a triad of impairments. These impairments are in communication, socialization, and repetitive patterns of behavior (Wolf, 2004). Autism affects about 1% of the current population (Shishido, Branko, & Norio, 2013). This disorder seems like a common diagnosis in the current day in age but the disorder was only discovered around sixty years ago. The two founding researchers that discovered the disorder are Kanner and Asperger. Since then there has been a significant amount of research on the disorder and they have narrowed down the criteria associated with Autism. Since the discovery of Autism Spectrum Disorder, there has been many debates on what causes this condition. When it was, a recent discovery scientist thought it could have been caused by many factors including psychological conditions and poor parenting. Now research has shifted in another direction (Wolf, 2004). In recent years, there has been a debate if childhood vaccinations or genetic mutations cause the disorder. This debate has led many parents to stop vaccinating their children in case it does cause the disorder. In 2010 (de los Reyes) the immunization rates fell to 80%. These parents’ decisions greatly effects the nation’s public health so it has fueled even more research to find the cause. A very common vaccine that has been said to cause the disorder is the measles, mumps, and rubella vaccine or the MMR vaccine. This

The disease called Alzheimer’s is the fourth leading cause of death in the United States (Weiner, 1987). It is estimated that the elderly population will double between now and 2030. During this period, the number of elderly will grow by an average of 2.8% annually (U.S. Census Bureau, 2001). By 2050, the number of people with Alzheimer’s is estimated to range from 11.3 million to 16 million (Alzheimer’s Association, 2005). These startling numbers should prompt an examination into one of the leading causes of death among this group of people. Understanding what Alzheimer’s is and the known causes of the disease are a good starting point. For those who have aging family members, knowing the risk factors and warning

Alzheimer's disease is one of the most common causes of dementia. The term 'dementia' describes a set of symptoms, which can include memory loss, changes in mood and problems with communication and reasoning. These symptoms occur when certain diseases and conditions, including Alzheimer’s disease, damage the brain. Alzheimer's disease could be described as a physical disease affecting the brain. During the course of the disease, protein 'plaques' and 'tangles' develop

Alzheimer’s disease is a complex illness that affects the brain tissue directly and undergoes gradual memory and behavioral changes which makes it difficult to diagnose. It is known to be the most common form of dementia and is irreversible. Over four million older Americans have Alzheimer’s, and that number is expected to triple in the next twenty years as more people live into their eighties and nineties. (Johnson, 1989). There is still no cure for Alzheimer’s but throughout the past few years a lot of progress has been made.

Alzheimer’s disease (AD) is a progressive and fatal form of dementia, frequently seen in the elderly altering their cognition, thought process and behavior. AD is reported in about half of patients that have a dementia diagnosis; one study states that about 10.3% of the population over 65 years is affected by dementia with an increase to almost 50% over the age of 8 (Beattie, 2002). Alzheimer’s disease is not a normal part of the aging process in humans, but rather found in a group of diseases that affect the brain leading to a decline in mental and physical control. AD when diagnosed has a very slow and gradual course, initially affecting the individual’s short term memory (Beattie, 2002). Alzheimer’s disease is the 6th leading cause of death, affecting more than five million people in the United States and is also one of the most common forms of dementia. Dementia can be defined as a disorder of progressive cognitive impairment severe enough to affect daily functions of an individual’s life (Fillit, et al., 2002).

Even today, after so much study, Alzheimer’s is not fully understood. However, researchers do agree that this degenerative disease is caused by the gradual buildup of fibrous protein compounds in the brain, which are known in the scientific world as amyloids. These amyloids in the brain area act like plaque and as a result of their presence, the normal brain functioning is disrupted.

The relationship between Asperger syndrome and autism has been a controversial topic in psychology. There is not a definite correlation which has been decided upon between the two and chiefly due to the fact that they are both overly similar. Concisely, psychologists seek to identify the main difference between them. In a simpler way, it is not yet clear whether autism and Asperger syndrome should be defined as independent (distinct) terms, or whether Asperger syndrome should be categorized under the wider realm of autism. In their researche, multiple scholars have come upon differing opinions and theories in support of their own perceptions of the two disorders which either agree or disagree at some point. Asperger syndrome is derived from Hans Asperger who is highly recognized for his efforts in defining the disease which many scholars had described as not diagnosable (Mayes, Calhoun & Crites, 2001).

It is a disease that we haven’t cured yet but instead have only come up and still coming up with treatment strategies to alleviate its symptoms. AD was first described in 1906 by a German psychiatrist by the name of Alois Alzheimer whilst he was performing a histophathologic study of his patient’s brain, a patient who had been suffering from dementia. His patient’s brain’s autopsy brought to light the presence of two types of lesions, which are senile plaques and neurofibrillary tangles. He saw a visible difference in the brain tissue for it was severely damaged by these lesions. Since then, our knowledge of AD’s cellular and molecular alterations has increased and we have come up with various hypotheses for AD that may soon help in developing effective preventative and therapeutic strategies. One of the most prevailing hypotheses that have already leaded to a number of therapeutic approaches is the amyloid cascade hypothesis. Hence, the following essay will explore the pathology of the amyloid cascade hypothesis and the evidence for and against it. It will also touch upon current progress in clinical trials that test the

Alzheimer’s disease (AD) is a cognitive neurodegerative disorder and one of the major forms of dementia; it represents 60-80% of the dementia patients (Barker et at., 2002). It is estimated by the end of 2015, 53 million people of America would be affected and this would almost double by 2025 and triple by 2050, hence making research momentous for the cure (Hebert et al., 2013).

Alzheimer’s disease (AD) is a slow-progressing neurodegenerative disease that has no cure and most often affects people over the age of sixty-five. Neurodegeneration is characterized by the loss of function in the central nervous system due to degeneration of neurons found mostly in the brain. The most recent data from the Center for Disease Control and Prevention shows that AD is the sixth-leading cause of death in the United States. The cause of Alzheimer’s is still not completely understood, but the current theory is that it appears to be genetic in which many genes are involved. AD is also the most common form of dementia and accounts for 60-80% of cases (Alzheimer’s Association 2016). Dementia is not a disease itself, but instead is characterized by a group of symptoms that is caused by brain disease or injury in which memory, personality, and reasoning skills are affected.

Alzheimer’s is a common disease. More than three million cases of Alzheimer’s come up each year. People of age sixty years and older are largely affected, with rare genetic changes connected to the early start of Alzheimer's

When a baby is born it is standard protocol for them to get a series of vaccinations to protect them from certain diseases like mumps, diphtheria, and even chicken pox for babies that were born in the late 1980’s and 1990’s. Taking your baby to the doctor to have these vaccinations was never even given an afterthought. It was what new parents did. While vaccinations were always thought to keep a child safe children started to have complications after a vaccination was given. The complication was Autism and it sent shockwaves through the parenting community. Parents began to question whether or not vaccinations were truly protecting their children or causing them to become Autistic. To some families this was a call for action. Did they

The research into Alzheimer's Disease has come a long way since 1906 when it is was discovered by Alois Alzheimer. He detected microscopic brain tissue changes called senile and neuritic plaques in deceased patients. These are chemical deposits consisting of protein molecules called Amyloid Precursor Protein(APP) that are fundamental components of a normal brain. However in the brain of an Alzheimer patient, an enzyme cuts the APP apart and leaves fragments in the brain tissue. These combined with degenerating nerve cells cause the plaques or lesions. These lesions are found in many sections of the brain including the hippocampus which regulates emotion and memory, the basal forebrain, and especially the basal nucleus of Meynert and the cortex, where the memory function is located.(2) Another sign of a diseased brain are neurofibrillary tangles, which are malformations within nerve cells.

The amyloid cascade hypothesis is the most widely accepted of the AD pathogenesis hypotheses. Its principle is that the accumulation of Aβ plays a major role in AD pathogenesis, and the disease is analyzed as a series of abnormalities in the process and secretion of the amyloid precursor protein (APP), where an inequality between production and clearance of amyloid β is the triggering event and the most important factor responsible for other abnormalities observed in AD (Hardy et al, 2002; Cummings et al, 2007). Amyloid β is a peptide with high resistance to proteolytic degradation. It consists of 37–43 amino acids with different isoforms (Deane et al, 2009). Aβ is the result of sequential cleavage of the amyloid precursor protein (APP), generating