The Mechanism Of Action Of Tetracycline

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1. What is the mechanism of action of tetracycline?

Tetracyclines were described for the first time in the 1940s and displayed activity against many microorganisms including gram-positive and gram-negative bacteria.

It is well known that tetracyclines restrict bacterial protein synthesis by avoiding the association of aminoacyl-tRNA with the bacterial ribosome. Consequently, to interrelate with their targets these molecules need to cross one or more membrane systems depending on whether the susceptible organism is gram positive or gram negative (Ranjan 2010).

Tetracyclines cross the outer membrane of gram-negative enteric bacteria through the OmpF and OmpC porin channels, as positively charged. The cationic metal ion-antibiotic complex
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They continue to lose clinical attachment despite having received periodontal therapy that proves effective in most patients. Furthermore, they typically have good oral hygiene. Theoretically, patients with refractory chronic periodontitis have a persistent infection that will most likely require diagnostic and treatment approaches beyond those that have already been attempted.
Furthermore, another group of patient that might need antibiotic coverage are the ones who had Aggressive periodontitis is an infrequent periodontal disease characterized by usually an early onset and rapid destruction in otherwise healthy patients. These patients as well they do not respond well to traditional therapy and bacteria (e.g. Periodontopathogens) play a bigger role.

In this case the patient had a local delivery of tetracycline, this could also be delivered systemically. Effectiveness of locally delivered antibiotic had been discussed in the literature. Some authors mentioned that it is more difficult for locally delivered antibiotics to be effective because in order for them to complete pharmacological objectives these three pharmacokinetic parameters have to be fulfilled: Delivery to the site, maintenance of concentration, and sufficiency of time. Purucker 2001 did a comparison between locally and systemically delivered antibiotics. After full mouth disinfection, 30 patients were randomly assigned tone of two antibiotic groups. The
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