NRTIs on the other hand, inhibits the mitochondrial DNA polymerase-γ in fat cells, this interferes with the respiratory chain reactions, thus reducing the cells ability to produce energy. As a result, the cell’s ability to oxidise fatty acids declines, causing a build-up of lactic acid and triglycerides within the cell (Sattler, 2008). Currently there are no clinically proven therapies for lipodystrophy and so AIDS patients usually need to change HIV drugs until a suitable combination is found. Lifestyle factors can also be controlled in order to reduce the effects of lipodystrophy, for example, exercising and having a healthy diet. These changes may help reduce fat build up and build muscle. Due to weakened immune systems, people with…show more content… Lesions in the gastrointestinal tract may cause pain, vomiting, diarrhoea, bleeding or malabsorption. There are different type of KS, each defined by the different populations it develops in. AIDS-related KS also known as Epidemic KS, is one of the most common type of KS in the United States and as the name suggests, it’s the type of KS that develops in people who are infected with HIV/AIDS-KS is the most aggressive form of the disease and is found in HIV infected individuals, particularly frequent in homosexual. KS is considered an “AIDS defining” illness, meaning that if the person shows signs of KS and is infected with HIV, the person definitely has AIDS. KS is prevalent in AIDS patients as it takes advantage of the weakened immune system of the patient in order to survive in the host body.
Studies conducted to understand the epidemiology and pathogenesis of KS show that globally, there is an uneven distribution of Kaposi’s sarcoma-associated herpesvirus (KHSV). Results show that areas, such as sub-Saharan Africa, have a higher prevalence of the endemic type KS. This type of KS tends to occur in younger people and usually affects the lymph nodes and other organs. However, Western Europe and United States have shown a low prevalence of endemic KS in the general population. Primary KSHV infection can occur during childhood and can also be transmitted via both sexual and non-sexual routes as an adult. Body fluids, including blood, saliva, semen and vaginal