The Pathogenesis Associated With Sle

2382 WordsFeb 27, 201510 Pages
Immune Mechanisms The pathogenesis associated with SLE is complex and attributed to various factors. These factors include sex, the imbalance of hormones, and ones’ hypothalamus, pituitary, and adrenal axes. Others have said that it is attributed to the cells in your body that are dying, over active help of the T cells in the body, defective B cells, and the shifting of the T helper 1(Th1) to T helper 2 (Th2), which are responsible for the B cells causing them to produce these pathogenic antibodies that cause SLE. (Cambridge, Teodorescu, et al. 2006.) Roles of T cells and B cells The immune system is composed of many types of cells, such as T cells and B cells, which are cells that defend your body from foreign substrates. When foreign substrates are introduced into our bodies, T cells and B cells that recognize this foreign substrate are being singled to destroy and or neutralize it. These cells rapidly proliferate and generate memory cells that will “remember” the foreign substrate. If the foreign substrate was to return the T cells and B cells have a stored memory of it, therefore they know how to attack it. The mechanism in which it happens is that the T cells secrete molecules in the cytokines which rely the information to the rest of the body that there is an invader present. (Sfikakis et al. 2005) When the B cells recognize a foreign substrate, the B cells become activated, which helps the T cells to secrete the “Y” shaped protein, known as antibodies to
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