The Pathogenesis Associated With Sle

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Immune Mechanisms The pathogenesis associated with SLE is complex and attributed to various factors. These factors include sex, the imbalance of hormones, and ones’ hypothalamus, pituitary, and adrenal axes. Others have said that it is attributed to the cells in your body that are dying, over active help of the T cells in the body, defective B cells, and the shifting of the T helper 1(Th1) to T helper 2 (Th2), which are responsible for the B cells causing them to produce these pathogenic antibodies that cause SLE. (Cambridge, Teodorescu, et al. 2006.) Roles of T cells and B cells The immune system is composed of many types of cells, such as T cells and B cells, which are cells that defend your body from foreign substrates. When…show more content…
B-cells, in particular, play a major role in SLE as then hyperactivity, caused by such cytokines as IL-10(discussed below) contribute to the pro inflammation of antibodies IL- 10 gene In Systemic Lupus Erythematosus, expression of the IL- 10 gene located on chromosome 1 (1q31-q32) is often inhibited. As the gene name implies, the gene encodes the cytokine IL-10, which is produced by inflammatory cells, such as monocytes and macrophages. (Yan, Bing, and Yi Liu. 2009). When this gene is inhibited the patient will show the signs of SLE, which are discoid lesions, and neurological disorder. When these symptoms begin to appear one can conclude that they have Systemic Lupus Erythematosus. The function of the IL- 10 gene is to enhance B cell production and the in tissue leading to the production of autoantibodies. This gene influences many other genes in the body which are associated with inflammation. Programmed cell death (PDCD1) Another gene with altered expression in SLE patients is the Programmed Cell death (PDC1), which encodes for the PD-1 Protein. The PDCD1 over expression has been observed to be in ethnic groups, such as Mexicans and certain European populations from Sweden. This polymorphism affects the transcription factors which contribute to the non- tolerance and the hyperactivity of lymphocyte is a major characteristic in SLE. Under normal expression Levels, the PD-1 protein helps to regulate T-cell and B-cell
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