The Pathology and Phases of Acute Renal Failure

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A man arrives at a clinic with complaints of asthenia, malaise, headache, weight gain, and a decrease in urination. A tentative diagnosis of acute renal failure is made.
1. Explain the pathophysiology of acute renal failure. Include prerenal, intrarenal and postrenal causes.
If the tubular and vascular meets together it may cause in acute renal failure. The main result of acute tubular necrosis is ischemia. If the ischemia goes on for two hours it may cause destruction of your kidney tubules. Too much cutback in glomular filtration rate (GFR) is an outcome of ischemia, start of renin-angiotensin system and clogging of tubular cause by cellular debris. As the tubular cells ruined by nephrotoxins and the cells are gone through necrosis and the tubules become more accessible. The outcome in filtrate absorption may cause a reduction of function in nephrons the capacity to eliminate waste.
The acute renal failure have 3 phases:
• Onset: Acute renal failure begins with asymptomatic condition going to tubular necrosis, like hemorrhage, may deduct red blood volume and renal perfusion. Enough treatment is given in this phase then your personal diagnosis is good.
• Maintenance: The repeated reduction of glomular filtration rate (GFR) and tubular necrosis outline this phase. Endothelial cell necrosis and discarding is the start of tubular obstraction and high tubular permeability. Resulting oliguria (less than normal urinary output) is a sign and symptoms during the start of this

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