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The Pathophysiology Of Depression

Decent Essays
Depression is a chronic, recurrent psychiatric disorder affecting nearly 21% of the world population (Gu et al., 2014; Lai et al., 2014). According to the world health organization (WHO) reports, it will become the 4th leading cause of disability worldwide by the year 2020 (WHO, 2001; Wang et al., 2013). The monoamine theory states that the brain neurotransmitters such as 5-Hydroxytyrptamine (5-HT), Norepinephrine (NE), and Dopamine (DA) assume to play a key role in the pathophysiology of depression (Patel and Galani, 2013). Clinically, at the early stages of depression, noradrenaline reuptake inhibitors (e.g. desipramine, reboxetine, etc.) and selective serotonin reuptake inhibitors (e.g. fluoxetine, citalopram, etc.) have been mainly exploited
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