The Pathway to Psychosis

1433 WordsJun 25, 20186 Pages
“How all occasions do inform against me” is a line from act IIII, scene IIII of William Shakespeare’s Hamlet. This line, spoken by Hamlet, expresses his emotional state as he is currently overwhelmed by the death of his father, the king of Denmark, and the situation surrounding it. After Hamlet learns of his father’s death he finds out that his mother has married Claudius, Hamlet’s uncle. On top of all of that, Hamlet soon after discovers that Claudius murdered his father in order to become king, and he takes it upon himself to avenge his father’s death. Throughout the play, the severe stress of the situation seems to take its toll on Hamlet putting him in a depressed state, and eventually over time he grows…show more content…
28-29). Following, childhood trauma was assessed with a questionnaire (Lardinois , Lataster , Mengelers, van Os , & Myin-Germeys, 2011, pp. 28-29). The findings of the study show a strong “interaction” between stress and childhood trauma, thus showing that childhood trauma is associated with “sensitivity to stress” (Lardinois , Lataster , Mengelers, van Os , & Myin-Germeys, 2011, p. 28). While this does not prove a cause-and-effect relationship between childhood trauma and an “emotional and psychotic” reactivity to stress, it strongly points to the possibility that a history of childhood trauma can lead to an individual reacting emotionally and psychotically to stress (Lardinois , Lataster , Mengelers, van Os , & Myin-Germeys, 2011, p. 28). Clearly, there is stress associated with childhood trauma and therefore it is possible that that childhood stress lead these subjects to develop psychosis. A study published in the journal of Psychological Medicine entitled COMT Val158Met moderation of stress-induced psychosis takes a biological approach to the question at hand. This study sought to examine the question of high reactivity to stress seeming to “represent part of the vulnerability for psychosis” (Stefanis, et al., 2007, p. 1651). The study’s objective was to determine whether a “functional polymorphism in the
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