The Physiological Effects of Cocaine in the Neurosystem Essay

One can feel the effects of cocaine almost immediately after use, with these effects lasting only a few minutes or hours. The duration of cocaine 's effects depends upon how it is administered. The faster the drug is absorbed, the more intense the high, but also the shorter the duration. The high from snorting is relatively slow to arrive but it may last 15 to 30 minutes. In contrast, the effects from smoking are more immediate but may last only 5 to 10 minutes. “In the brain, cocaine interferes with the chemical messengers -- neurotransmitters -- that nerves use to communicate with each other. Cocaine blocks norepinephrine, serotonin, dopamine, and other neurotransmitters from being reabsorbed. The resulting

The long term effects of cocaine are very extreme. Once having tried cocaine, an individual may have difficulty controlling the urge to use the drug and the perspective might change leaving the consumption of the drug as primordial. Cocaine’s stimulant and addictive effects are due primarily as a result of its ability to stop the reabsorption of dopamine by nerve

For short-term use, cocaine can provide extreme happiness, enhanced sensitivity to sound and touch or mental alertness. People takes cocaine as it can provide energy on their work but a long-term use of cocaine may lead to malnourishment, irritability, restlessness, paranoia and auditory hallucination (NIDA, 2016; Roncero, C., et al., 2013). Also, cocaine abuse may have other complications such as nosebleed because of snorting, difficulties in swallowing and easily infected by HIV or hepatitis C through needle injection and the misjudgment on having unsafe sex (NIDA, 2016). On the other hand, long-term use of cocaine may lead to addiction and a stronger dosage will be taken when they have any withdrawal symptoms. For instance, symptoms of depression, fatigue and increased appetite. Nowadays, still no medicines were approved for treating the addiction on cocaine and thus the treatment of cocaine addiction is

Cocaine’s mode of action has been shown to involve the dopamine receptors. This paper will discuss how cocaine affects dopamine receptors, the mode of addiction, how cocaine affects the frontal brain metabolic activities, as well as the role of excitatory amino acids in cocaine’s mechanism. I will also discuss how cocaine affects another system through its mechanism on the brain—the renin angiotensin system.

“There are changes in the brain caused by drug use that occur and persist, but are only unmasked after withdrawal from a drug — in this case, cocaine," senior author David Dietz explained in the press release. "Cocaine use alters the connections between certain neurons through changes in the shape of the cells."

As a coach, I had a player, who was very polite and worked hard in practice. She was very timid around other teammates. She would stop in to talk to me and never had friends that I could see her relate to. Trying to fit in desperately, she was happy to be included in the “social” activities in college. She got pregnant and her boy friend and her were arrested for conspiracy to deliver cocaine and both sentenced to prison. This course states cocaine can cause an initial rush of pleasure that makes you alert, talkative and confident. With prolonged exposure to meth and cocaine, it can destroy up to 50% of dopamine – producing neurons in certain parts of the brain. This can lead to irreversible symptons of Parkinson’s disease. (Cocaine handout) After several letters from her in prison, she thanked me for being a good listener. I know her family closed their eyes thinking it’s not an addiction, but a social activity that they can quit at any time. This course explains how a higher level of dopamine on a regular basis is needed just to keep you feeling normal. Cocaine can make people feel paranoid, angry and hostile even when they are not high. Prolonged use causes sleep deprivation and loss of appetite. A person can become psychotic and experience hallucinations. It increases the risk that the user will experience a heart attack, stroke, or respiratory failure which can result in sudden death. (Foundation for a Drug-Free

Cocaine binds to the dopamine reuptake transporters, thus blocking them from functioning. (See web reference (5). for an animation of this process.) As a result, dopamine levels increase in the synapse, and consequently, the receiving neuron is continuously stimulated. This constant firing of the neurons leads to a feeling of euphoria. In addicts, cocaine blocks between 60 and 77 percent of the DAT binding sites; in order to attain a "high," at least 47 percent of the binding sites must be blocked by cocaine. (6).

Methamphetamine and cocaine are both in the category of drugs known as stimulants. “Central nervous system are drugs that increase not only the activity of the CNS but also that of the ANS, (autonomic nervous system) resulting in both euphoria and mood enhancement” (Csiernik, R. 2014).

Stimulant drugs rev up the central nervous system by increasing heart rate, respiration, and blood pressure. Thus, someone who abuses stimulants will experience enhanced positive emotional reactions and a minimized level of negaitve emotional reactions, as well as alertness. Someone who abuses nicotine, a stimulant, will experiecne relaxation and alertness due to the way in which nicotine activates receptors sensitive to the neurotransimitter acetylcholine. Someone who abusues the stimulant cocaine will experience euphoria, enhanced mental and physical capabilities, stimulation, a decrease in hunger, indifference to pain, and diminished fatigue. Crack cocaine will generate intense euphoria, but will follow with unpleasant feelings. Stimulants

When cocaine is used an electrical signal in the presynaptic nerve cell release neurotransmitters across the synaptic cleft to bind to receptors on the postsynaptic cell. Once the neurotransmitters are bound to the receptors a release of a new electrical signal occurs in the postsynaptic cell. The neurotransmitters are gradually removed from the receptors and brought back into the presynaptic cell through neurotransmitter specific reuptake pumps on the lining of the presynaptic cell. Cocaine affects the levels of dopamine, serotonin and Norephedrine by blocking the reuptake pumps.This results in excess levels of the neurotransmitters to be in the synaptic cleft. These high levels of neurotransmitters continue to bind to receptors which releases more electrical signals to the postsynaptic neuron. Over time this hyperactivity of the neuron causes the postsynaptic cell to reduce the number of receptors on it. Once the hyperactivity stops in the postsynaptic cell normal cell function resumes. However with fewer receptor cells the user feels a lessened sensation of the neurotransmitters. The physiological effects of cocaine can be attributed to the chemical process it disrupts in the nerve cells. Loss of appetite, disturbed sleep patterns, nausea, anxiety, paranoia and depression are attributed to altered serotonin levels. Increased heart rate, increased blood pressure, increased body temperature, contracted

The use of cocaine has many different and negative effects on the human brain. “Cocaine increases levels of the natural chemical messenger dopamine in brain circuits controlling pleasure and movement” (“DrugFacts-Cocaine”). The average human brain will release dopamine in order to send

Regular use comes with long term psychological effects can include restlessness, irritability, anxiety, and paranoia. In severe cases regular use may lead to a complete psychosis, where the user loses touch with reality, and experiences auditory hallucinations. Some of Cocaine’s long term effects are unique to the method of taking it. Snorting, for example, may lead to damage to the organs of the respiratory system. Orally ingested cocaine may lead to a severe case of bowel gangrene. Injecting Cocaine comes with the inherent hazards of either using or sharing needles such as a risk of contracting HIV, other bloodborne diseases , and the damaging of veins that produces track

However, everything comes at a price, the short-term health effects are: constricted blood vessels, dilated pupils, nausea, raised temperature and blood pressure, faster heartbeat, tremors and muscle twitches, and restlessness. The long-term effects of cocaine depend on how it is taken. If it is snorted effects include: loss of sense of smell, nosebleeds, frequent runny nose, and problems with swallowing. Ingesting orally leads to severe bowel decay from reduced blood flow. If it is injected, the effects include higher risk of contracting HIV, hepatitis C, and other bloodborne diseases. However, those who use non-needle forms of cocaine are still at risk for STDs because cocaine affects one’s judgement so one may lead to unsafe sexual behavior. Long term effects shared by all forms of cocaine include: being malnourished due to cocaine’s appetite suppressing properties, movement disorders such as Parkinson’s, irritability, restlessness, and severe paranoia which can lead to the loss of touch with reality and cause auditory hallucinations. Along with all the previously mentioned effects, if someone becomes dependent on cocaine, withdrawal symptoms include: depression, fatigue, increased appetite, nightmares, insomnia, and slowed cognitive function. I personally know someone who has tried cocaine and here’s what they said on the matter:

Introduction: The use of cocaine continues to be a drug problem in the Unitied States. Its inhibitory action on dopamine reuptake leads to significant euphoric and motor effects. One of the visually dramatic responses of cocaine use is choreoathetoid (dance-like) movements. These movements are often unapparent to the individuals themselves.

The drug Cocaine alters chemical levels in the brain which can lead the user to have the ‘feel good’ factor.