The Physiological Effects of Cocaine in the Neurosystem Essay

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Cocaine abuse and dependence affected 1.4 million Americans in 2008 (Volkow, 2010). Cocaine is known for its addictive properties (Letchworth et al., 2001). Therapeutic and medicinal techniques utilized to relieve drug effects and drug seeking behavior have become increasingly popular in the scientific community. In general the affected areas during or after cocaine use have been identified subsequently providing research into the physiological aspects of cocaine use. Research to determine drug-seeking and relapse is imperative due to the prevalence of cocaine use and the rehabilitative qualities a medicinal cure could provide. Brief Review of Cocaine Cocaine is a Schedule II drug, known for its addictive properties and permissive…show more content…
Consequently, the increase of DA in the synaptic gap increases the likelihood and intensity of the action potential in the post synaptic neuron (Carlson, 2013). Effects of Cocaine Administration Physiological effects of cocaine administration include: constricted blood vessels, dilated pupils, increased body temperature, heart rate increase, blood pressure increase, brain adaption along reward pathways, and decreased sensitivity to rewarding stimuli (Volkow, 2010). Regular use of cocaine may cause hallucinations, delusions of persecution, mood disturbances, and repetitive behaviors (Carlson, 2013). Acute euphoria caused by cocaine presents as excitability, hyper vigilance, and anxiety (Nnadi et al., 2005). Physical effects include feelings of euphoria, energy, hyperactive language, mental alertness, heightened awareness of the senses especially sight, sound, and touch. Cocaine administration also causes appetite suppression and seems to make physical and intellectual tasks quicker (Volkow, 2010). Long-term effects of cocaine administration share a positive correlation between dose amount and deterioration of neurocognitive functioning including impairment of the visuomotor track and processing speed; changes may result through neuroadaption, direct toxicity, or neuroschemia expressed by mental distress, altered frontolimbic

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