The Preparation Of Grignard Reagents

Any amount of H2O present would react with and therefore ruin the Grignard reagent. The negative charge on the Grignard carbon would pop a proton off of water, and the resulting hydroxide would react with MgBr2. Since all of the water and moisture was removed, the reaction should run successfully. For this experiment’s reaction, bromobenzene is turned into phenylmagnesium bromide, a Grignard reagent. Then, the Grignard reagent is reacted with benzophenone to yield a molecule with a negative charge on the oxygen. This molecule is worked up and protonated to yield triphenylmethanol.

During the halogenation reactions of 1-butanol, 2-butanol, and 2-methyl-2-propanol, there is a formation of water from the OH atom of the alcohol, and the H atom from the HCl solution. The OH bond of the alcohol is then substituted with the Cl atom. Therefore all of the degrees of alcohol undergo halogenation reactions, and form alkyl halides as products. This is because the functional group of alkyl halides is a carbon-halogen bond. A common halogen is chlorine, as used in this experiment.

Solvent choice is important in Grignard reagent formation. The solvent must be non-reactive with a negatively charged carbon (ex. acetone or anything even slightly acidic), and the solvent cannot have a carbonyl group. The solvent must be a volatile solvent that provides a blanket of solvent over the reaction solution so that oxygen and moisture in the air are excluded from the reaction. Oxygen and moisture in the air are very slightly acidic and would disrupt the synthesis of a Grignard reagent. Anhydrous ether (R2O) is often used as a solvent in creating Grignard reagents because it keeps out water and oxygen, makes the

For this experiment, an organometallic reagent was used for the synthesis and isolation of benzoic acid. The Grignard reaction is the addition reaction of an organometallic reagent, which in this case was an organomagnesium reagent. An organometallic reagent is a carbon bonded to a metal. This reagent was combined with an electrophile, a carbonyl compound such as a ketone or aldehyde. Carbons are electrophilic when bound to a nonmetal thus the atoms are more electronegative than the carbon and metals are less electronegative than carbon.

Organometallic compounds, such as Grignard reagents, are molecules containing carbon-metal bonds and are often used to create new carbon-carbon bonds. Grignard reagents—or organomagnesims— are specifically those that have a carbon-magnesium bond.

It is expected that the concentration of hydrochloric acid will increase the rate of the reaction between magnesium ribbon and hydrochloric acid. By increasing the concentration of

The Grignard reaction is an important synthetic process by which a new carbon to carbon bond is formed. Magnesium metal is first reacted with an organic halide forming the Grignard reagent. The Grignard reaction is the addition of an organomagnesium halide (Grignard reagent) to a ketone or aldehyde, to form a tertiary or secondary alcohol, respectively. For example, the reaction with formaldehyde leads to a primary alcohol. Grignard Reagents are also used in the following important reactions: The addition of an excess of a Grignard reagent to an ester or lactone gives a tertiary alcohol in which two alkyl groups are the same, and the addition of a

The purpose of this experiment is to determine the nucleophilic strength of chloride and bromide ions as it reacts with 1-butanol (n-butyl) and 2-methyl-2-propanol (t-butyl alcohol) under SN1 and SN2 conditions.

The purpose of this experiment is to examine the reactivities of various alkyl halides under both SN2 and SN1 reaction conditions. The alkyl halides will be examined based on the substrate types and solvent the reaction takes place in.

In a 25-mL round-bottom flask, 1-chlorobutane (5 mL, 4.32 g, 0.046 mol), sulfuryl chloride (1.6 mL, 2.7 g, 0.02 mol), 2,2’-azobis-(2-methylpropionitrile) (0.03 g), and a boiling chip were added. After a condenser and gas trap were attached to the flask, the mixture was heated to a gentle reflux in a steam bath for 20 min. The flask was then allowed to cool down quickly in an ice bath for a short time before a second portion of the 2,2’-azobis-(2-methylpropionitrile) (0.03 g) was added to the flask. The mixture was refluxed for another 10 min. before the flask was cooled in a beaker of water. The reaction mixture was then poured into a small separatory funnel already filled with water (10 mL),

The reaction took place in a conical vial and .2mL of each of the reactant samples were added to it along with some 95% ethanol. Two drops of NaOH were added shortly after and stirred at room temperature for fifteen minutes. The vial was cooled in and ice bath and crystallized. Vacuum filtration was performed to filter the crude product. The crude product was recrystallized using methanol and filtered again. We made one change to the procedure and instead of using .7mL of ethanol we

Through the use of the Grignard reaction, a carbon-carbon bond was formed, thereby resulting in the formation of triphenylmethanol from phenyl magnesium bromide and benzophenone. A recrystallization was performed to purify the Grignard product by dissolving the product in methanol. From here, a melting point range of 147.0 °C to 150.8 °C was obtained. The purified product yielded an IR spectrum with major peaks of 3471.82 cm-1, 3060.90 cm-1, 1597.38 cm-1, and 1489.64 cm-1, which helped to testify whether the identity of the product matched the expected triphenylmethanol. The identity of the product being correct was further confirmed by way of both proton and carbon-13 NMR spectra. This is due to the fact

The purpose of this lab was to synthesize triphenylmethanol from benzophenone and bromobenzene by the formation of a Grignard compound with the reagents bromobenzene and magnesium metal. The bromobenzene was first transformed into the Grignard compound and was then reacted with the benzophenone to make the final product. The mixture was then mixed with sulfuric acid and the organic layer was extracted via a separatory funnel. The mixture was then recrystallized from methanol and was allowed to dry and the percent yield, melting point, and the IR was obtained. The mass of the product obtained was 5.45 grams and the percentage yield was determined to be 41.95%. The melting point range obtained from the final product was 89-91°C

Reviewing the many possible reactions that can occur with carboxylic group, there are two which stand out as useful for cross-linking purposes. The carboxylic hydroxyl group can form covalent bonds by reacting with an amine group, and through Fisher esterification by reacting with a hydroxyl group (Jones 871). Thus a molecule with a carboxylic group can react with the amine groups on amino acids and nucleotides as well as the hydroxyl groups of carbohydrates. A molecule with two carboxylic groups could then feasibly react with any combination of amino acids, nucleotides, or carbohydrates, acting like linking pieces to form larger hybrid molecules. 4.

Emotions can be seen as a weakness, but in other ways emotions can be seen as a strength; some emotions can cause a person to achieve higher while others can cause them to fail harder. I believe that almost every person in the world has one part of their personality, he or she wishes he or she could change. One emotion I wish I could change would be my irritability. In Tagolog, we have this term we say when someone is easily irritated, its called, “pikon” (pee-koe-n). Throughout my 22 years of life, I have been called this term by my family way too often, to the point where they think I’m being, “maarte” (Ma-are-te) or overdramatic. I find it really easy to allow my temper to show especially when I feel that I am being disturbed or annoyed by another person or objective I am trying to complete. The easiest moments when I feel irritated are when I’m playing video games or being nagged by my family. Throughout this project, my goal was to allow myself to not be as irritable as normal, and to become more level headed and calm in the face of annoyance. I aimed to feel this emotion at least half the amount of times than I usually do, so hopefully it would only happen one to two times a day, five times a week max. The strategies I chose to do for this experiment was: 1) Distracting myself, 2). Ignoring the thing or person that is irritating me, and 3) countdown from 15 to 0 to calm my head.