The Probability of Inheriting a Disease Is Not Random

In order to get Sickle Cell Anemia, you must have the Sickle Cell Trait. This is defined as "A person who carries one sickle hemoglobin producing gene inherited from their parents and one normal hemoglobin gene." (3) People who only have one copy of the mutation have the trait. "It is estimated that 1 in 12 African Americans has sickle cell trait." (3) Having the trait will NOT cause SCD. However, having the gene does allow you to pass the mutation on to your children. In fact, "A child conceived by two people with sickle cell trait has one chance in two of also having sickle cell trait, one chance in four of having sickle cell anemia."(3)

Sickle cell anemia occurs when a person inherits two abnormal genes (one from each parent) that cause their red blood cells to change shape. Instead of being flexible and round, these cells are more rigid and curved in the shape of the farm tool known as a sickle - that's where the disease gets its name. The shape

In this article, sickle cell anemia is defined as a hereditary disease that destroys red blood cells by causing them take on an elongated and rigid "sickle" shape. In addition, a different type of hemoglobin called Hemoglobin S, is the protein in red blood cells that carry oxygen throughout the body. This protein starts to wrap around other red blood cells when oxygen is lacking to form a helical shape. Once this happens the cells cluster together and elongate and the cells start to "sickle". A person who has sickle cell anemia can only get it if both of their parents carry the sickle cell trait, if only one parent has the trait then there children are at risk for having the trait.

The Sickle Cell gene needs to be inhered from both of the parents; otherwise the individual will only carry the Sickle Cell trait. If the sickle cell trait is carried by an individual they can be asymptomatic. This individual can, however, transfer the gene abnormality to any offspring that they have. Sickle Cell Anemia is the most common form of sickle cell disease. It is also the most severe form of the disease. One variation of sickle cell anemia is hemoglobin SC disease and is one of the more common variations. Many times it manifests with a lesser degree of hemolytic anemia (1).

Sickle cell disease is categorized as an autosomal recessive disease. That means in order for one to inherit the disease, they must inherit two recessive alleles for sickle cell disease, or hemoglobin S gene. Having only one recessive allele makes you a carrier. The disorder causes the affected person’s red blood cells to disfigure into a crescent or sickle, which differs from the normal red blood cells that shaped into a doughnut. Sometimes, cells in a sickle shape cannot get through the narrow passageways of the blood vessels as easily as normal red blood cells. This blocks blood from entering and oxygen can’t reach the affected person’s organs. It can also crystallize and block arteries and

The cause of sickle cell anemia is by a mutation gene. The gene tells your body to make hemoglobin. Hemoglobin is responsible for giving the blood its red color and allows the red blood cells to carry oxygen from your lungs to all the parts of your body. The sickle cell gene is passed down from one generation to the next and is inherited. It is called autosomal recessive inheritance. This happens when both the mother and father pass on the detective form of gene. If only one parent passes on the sickle cell gene to the child that means the child will have the sickle cell trait. People who have the sickle cell trait are carriers and can pass the defective gene to their children. Your ethnic background can put you at risk for sickle cell anemia.

The disorders for Sickle Cell Anemia is mutation, autosomal recessive, and blood loss. The chromosomes traveled from one parent to another which mean it's a positive chance the child will have that disease. Also that

The disease I choose to talk about is Sickle Cell anemia, which is a blood disease that is prevalent among the African American race. This disease is interesting to me because it is a hereditary disease, so it can only be contracted if your parents have the disease. Sickle Cell anemia is caused by abnormal hemoglobin, the red blood cells in your body contain two vital hemoglobin molecules, a protein that carries the oxygen through your blood to travel throughout the body. People with sickle cell anemia, they have two copies of abnormal hemoglobin referred to as hemoglobin S. The molecule is what causes the problems within the red blood cells, rendering them unable to properly complete the process of carrying oxygen where it needs to go.

Sickle cell anemia is the most common disease among African Mediterranean dissent; sickle cell anemia affects millions of people worldwide. There are 5 different types of Sickle Cell Disease which are Sickle Cell Anemia, Sickle-Hemoglobin C Disease, Sickle Beta Thalassemia Disease, Sickle-Hemoglobin D Disease, and Sickle-Hemoglobin O Disease. Sickle Cell Anemia is when a child inherits the Sickle Cell Disease gene from both parents in which they may gain the symptoms of Sickle Cell Disease, Sickle Cell. Anemia is when the blood has a low number of normal red blood cells in the body. People with Sickle-Hemoglobin C Disease have a somewhat different replacement of the Sickle Cell Anemia gene, there may be comparable symptoms but there are

When the chromosomes are inherited, a mutated gene can be passed from carrier or afflicted parents to their offspring. The inheritance of sickle cell disease therefore depends on this mutation. Afflicted people have a mutation on chromosome 11 which codes for the beta subunit of haemoglobin. It reflects a single base change (GATGTT) of amino acids that distorts the erythrocytes into a severely concave shape at low oxygen concentrations (reference). If one beta globin is sickle and the other is normal, the person is not anaemic, however they are an autosomal heterozygous carrier of sickle cell disease. If both beta globin genes are affected by the mutation, the person is homozygous recessive and becomes

According to National Heart, Lung, and Blood Institute (NIH), About 1 in 13 African American babies is born with sickle cell trait. About 1 in every 365 black children is born with sickle cell disease. There are also many people with this disease who come from Hispanic, southern European, Middle Eastern, or Asian Indian backgrounds. Approximately 100,000 Americans have SCD. Sickle cell is a disease that is genetic but, does not have to affect every member in the family. Persons with sickle cell trait (SCT) are heterozygous carries of an abnormal B-globin gene that results in the production of an abnormal hemoglobin, Hb S, which can distort red blood cells (Ojodu, Hulihan, Pope, & Grant,

The married couples I am counseling both carry the sickle cell trait. In sickle disease, the red blood cells are shaped like the letter C. The red blood cells are more likely to occlude blood flow by clogging the blood vessels due to its unusual shape. This can cause their future child to be in severe pain and a potential stroke. The married couple can have a prenatal test done to see if their unborn child inherited the disease. Chronic villus sampling and amniocentesis are the prenatal tests done to detect genetic disorder (Sickle cell Society, 2013). Their future child has a 50% chance of having the sickle cell trait, if both parents have the sickle cell trait. The future child has a 25% chance of having the sickle disease when both parents have sickle cell trait (Centers for Disease Control and Prevention, 2017).

This disease is a genetic disease and it is hereditary. It is inherited as an autosomal recessive disease. This means that in order to get the gene you must receive a recessive trait from your mother and your father. The parents could both be heterozygous for the trait and therefore not have the disease, but instead they would both be a carrier. There are only a few ways that the parents could possibly pass the trait. One possibility of having a child with sickle-cell disease is if both parents are heterozygous and they both pass on their recessive allele, (25% chance for offspring to have sickle-cell disease). Another possibility

Sickle Cell Disease is an inherited blood disorder that affects the red blood cells. The red blood cells that turns normal red blood cells that are healthy and functioning into cells that are shaped sickled and crescent moon form become severely low and anemic. The oxygen - carry molecule in red blood cells that are called hemoglobin that creates an error in the red blood cell, that makes the cell sickled. When the sickled shaped cells block small vessels the condition results in oxygen depletion to the tissues surrounding the blocked vessels, Which the damages tissues causes many health

Sickle Cell Anemia is a group of disorders that cause red blood cells to become misshapen and break down. Sickle cell disease is the most common inherited blood disorder in the United States, affecting 70,000 to 80,000 Americans (Ashley-Koch, Yang and Olney). Sickle Cell Anemia causes your red blood cells to be thin, stiff, and shaped like a sickle. But your red blood cells are supposed to be round and soft. A person that is diagnosed with sickle cell anemia, their blood cells start to become clogged, causing blood clots, which can cause a great amount of health issues including: infections, stroke, and acute chest syndrome. People get sickle cell anemia by inheriting a mutated gene from both of their parents. On the down side, there is not currently an effective cure for sickle cell anemia, there are several different therapeutic approaches to treating and attempting to cure the disease and help people who are affected with sickle cell anemia better manage their symptoms. There have also been several great scientists that dedicated a lot of research to help find a cure for sickle cell anemia.