The Problem Of Tb Infection And Disease Management

1649 Words7 Pages
MTB has been associated with human disease for thousands of years and this success to great extent is due to its ability to survive within the host for months or even decades in latent state. In the past few decades, however, it has also evolved itself into various new forms, especially as multidrug resistant (MDR) and extensively drug resistant (XDR) forms causing several outbreaks. For outbreak and contact tracing, DNA fingerprinting technology is now an accepted and widely used method. The population structure of MTB is geographically subdivided, and these genetically different lineages have adapted to their local human populations, as is evident from molecular epidemiology. However, scientific evidence for such an adaptation is…show more content…
Owing to the special geographical diversities and living conditions, the predominance of different genotypes might imply their long-standing presence in these regions and may be linked with exponential contact with other populations.

Mounting evidences suggest that MTB evolved as a human pathogen in Africa and further spread took place with the first migrations of modern humans out of Africa around 70,000 years ago. Among many of the early studies of phenotypic and genotypic relevance, the one consistent finding was that tubercle bacilli from South India were less virulent and more susceptible to oxidative stress when compared to isolates form Great Britain. South Indian strains were also found to be devoid of sulpholipids. Even though strains of these earlier studies were not genotyped, on the basis of our current knowledge of the global phylogeography of MTB, it can be assumed that most of the South Indian strains belonged to Lineage 1 (Indo-Oceanic)[17]. We found clear demarcation in the compartmentalization of MTB lineages of this study isolates with respect to their geographical locations. Clustering can be used in post-genomic data analysis to group strains with similar traits. Clustering of individual SITs varies from region to region. Although spoligotyping may correctly identify “outbreak” episodes and can track the spread of the
Get Access