The Process And Implications Of Bone Remodeling

1740 Words Oct 16th, 2014 7 Pages
Abstract
This paper summarizes the process and implications of bone remodeling as proposed by Svetalana V. Komarova, Robert J. Smith, S. Jeffrey Dixon, Stephan M Sims, and Lindi M. Wahl. Bone remodeling in the human body is an intricate process where osteoclasts resorb existing mineralized tissue and osteoblasts form new bone. Bone remodeling involves various interactions between different cells in the osteoclasts and osteoblasts. A problem occurs when these interactions are disturbed and can lead to numerous different bone disorders such as osteoporosis, osteoarthritis, or Paget’s disease. Manipulating Frost’s mechanostat theory, a theory that describes bone biology, and its corresponding biomechanical mathematical models of bone, Komoarova, Smith, Dixon, Sims, and Wahl were able to form their own model that allowed them to analyze how a change in interactions between cells can affect the bone remodeling process.
Introduction
Bone remodeling is an important process in the human body, that, when disturbed, can lead to various disorders. The asynchronous process of bone remodeling involves bone resorption from the osteoclasts followed by bone formation from the osteoblasts. Furthermore, autocrine and paracrine regulators are involved and allow for interactions between the osteoclast and osteoblast.
In this paper we will look at the two different types of bone remodeling, targeted and random. We will then form a model that serves to simplify this complex process in…
Open Document