The Relationship Between Antioxidants From Diet And Supplements And Risk Of Pca

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Objective The objective of Study 1 (S1) was to review the relationship between antioxidants from diet and supplements and risk of PCa. The antioxidants included were vitamin E, selenium, vitamin C, carotenoids, and polyphenols from coffee and tea. Combination studies were also included. Method The method of S1 was a literature search utilizing the database Pubmed for studies that contained subheadings of diet, antioxidants, and prostatic neoplasms. The reference of selected studies was reviewed to identify additional articles. Studies that only examined plasma levels were excluded. Selected were 12 intervention studies and 32 observational studies. Results The evidence of vitamin E was inconsistent, the majority found no benefit for the vitamin E. Selenium was found to have some protective effect, the findings were restricted to patients with the lowest concentration at baseline and indicated a confounding effect of selenium deficiency. Other studies found no effect of selenium on PCa. The Initial benefits of Vitamin C was attenuated once vegetable intake was taken into account. Carotenoids provided inconclusive evidence, demonstrating no relationship with PCa. Three studies of green tea were performed, one each of intervention, prospective, and case studies. After 1 year PCa was significantly less prevalent in the green tea test group than the controls. Dietary flavonoids were not associated with PCa risk. Coffee was inversely associated with lethal, but not low-grade

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