The Relationship Between Cystic Fibrosis And Tuberculosis

Cystic Fibrosis is an inherited condition. However, the gene for Cystic Fibrosis is recessive and

Cystic Fibrosis is a chromosomal abnormality, meaning that one of the 23 pairs of chromosomes are not what they are supposed to be. A person without Cystic Fibrosis has a gene in chromosome 7, which produces a normal and substantial amount of protein called Cystic Fibrosis transmembrane regulator (CFTR), which in turn produces thin and watery mucus. A person with Cystic Fibrosis has a gene in chromosome 7, which produces either abnormal CFTR protein or no CFTR protein at all, which causes the body to produce thick and sticky mucus. People who are born with Cystic Fibrosis have two copies of the gene. One gene is received by each parent. In most cases, parents of people with Cystic Fibrosis, usually both carry the gene, however, the Cystic Fibrosis gene they are carry is recessive compared to the normal gene, allowing the normal gene it take over due to its dominance. This means that they do not have Cystic Fibrosis themselves. According to Cystic Fibrosis Queensland (2015) there is a one in four chance a person will have Cystic Fibrosis, a two in four chance that person will have the gene but not the disease and there is a one in four chance that the person will not have the disease or gene at all. The Cystic Fibrosis gene is easily passed on, however, the disorder not so much. The disorder is only passed on if a person obtains both the Cystic Fibrosis genes from their parents.

Cystic Fibrosis is a single gene disease, the Cystic Fibrosis Transmembrane Regulator gene is what causes CF, more than 900 mutations of this single gene has been discovered. Every person inherits two CFTR genes, one from each parent. Children who inherit a faulty CFTR gene from each parent will have CF. Children who inherit one faulty CFTR gene and one normal CFTR

A defect in the CFTR gene, or cystic fibrosis transmembrane regulator gene, is what causes Cystic Fibrosis. Every person inherits two of these genes, one coming from each parent. If a child inherits a faulty CFTR gene from both parents they will have CF. If a child inherits only one faulty CFTR gene, they are considered “CF carriers” ("What Causes Cystic Fibrosis?," 2013). More than 10 million Americans are carriers of the defective CF gene ("Cystic Fibrosis Foundation – Testing for Cystic Fibrosis," 2014). Carriers are able to live a normal, healthy life and they usually have no symptoms of CF, however, they could pass the faulty CFTR gene down to their children ("What Causes Cystic Fibrosis?," 2013). Carrier testing is available to help people identify if they could pass down the gene. The test uses blood samples or scraped cells from inside the cheek to look at a person’s genetic material ("Cystic Fibrosis Foundation – Testing for Cystic Fibrosis," 2014). The figure below shows how the CFTR gene can be inherited (Kotrla, 2014).

Cystic Fibrosis is an inherited recessive gene which means the disorder won’t affect anyone that’s a carrier. To obtain Cystic Fibrosis there are two ways, either, one parent is a carrier and the other has it (provided the parent with Cystic Fibrosis is female), or both parents are carriers. Parents can find out if they are carriers for Cystic Fibrosis with the use of genetic testing. When both parents are carriers for Cystic Fibrosis there a 25% chance the child will have Cystic Fibrosis, a 50% the child will be a carrier, and a 25% chance the child will not have Cystic Fibrosis nor be a carrier for it. In the United States there is about 30,000 reported cases of children and adults with Cystic Fibrosis, in the US there is an additional 1,000 cases reported each year, worldwide around 70,000 children and adults have Cystic Fibrosis. Cystic Fibrosis is the most common

To begin, cystic fibrosis is a genetic disease that causes persistent lung infections and limits the ability to breathe over time. It is an inherited disorder both parents have to be a carrier of the gene. Some people say if a both parents have the gene then their is a 50% chance that the mother will have a baby with the disorder. It affect the

A single person has two CFTR genes. They get one copy from each parent. If an adult or child has only one abnormal copy of this gene, they are a carrier of Cystic Fibrosis. A carrier simply means that they carry the trait for cystic fibrosis, and could give it to one of their children. If each parent gives a child one abnormal copy of the CFTR gene, this is when CF occurs. However if they only have one abnormal copy, the child becomes a carrier. When both parents are CF carriers, there is a 25% chance that their child will have Cystic Fibrosis.

Every person inherits two CFTR genes, one from each parent. Children who inherit a faulty CFTR gene from each parent will have Cystic fibrosis. Children who inherit one faulty CFTR gene and one normal CFTR gene are "CF carriers." CF carriers usually have no symptoms of CF and live

Cystic Fibrosis is a genetic disease. A person with CF has inherited two copies of the defective CF gene. One copy of the defective gene is inherited through each parent. A person with only one of these defective genes is considered a carrier but does not have CF. When two carriers have a child, there is a 25% chance the child will

Cystic fibrosis causes mucus to become extremely thick and sticky. The disease found in the lungs, pancreas, liver, intestines, and more but mostly affects the lungs. The disease is a recessive trait that is passed down through generations of caucasians, but is not contagious. The protein that is affected is CFTR (or cystic fibrosis transmembrane conductance regulator) which controls the flow of salts and fluids in and out of cells. The chromosome that is affected is chromosome 7. Even if one of the parents does not have the disease they could be a carrier and pass on the gene to their child. Usually, people with this disease have germs that are not affected by

i. Cystic Fibrosis (CF) affects those that are homozygous recessive for the F508del mutation in the CFTR (Cystic Fibrosis transmembrane conductance regulator) gene

Cystic Fibrosis (CF) is an autosomal recessive gene that causes a wide range of symptoms because there are over 1,000 changes or mutations that can occur within the cystic fibrosis transmembrane receptor (CFTR) protein. The CFTR protein is generally a chloride ion chain “regulated by cyclic adenosine monophosphate and therefore can act as a regulator of other electrolyte channels”(Grossman, S., & Grossman, L. 2005, p. 46). Typically this protein allows chloride ions to exit mucus-producing cells allowing water to flow in and thin the mucus. However, if the CFTR protein has been mutated, such as in cystic fibrosis, chloride ions cannot exit. This causes the mucus to thicken, become sticky, and obstruct the various channels it passes through. This build up of mucus also prevents bacteria from being cleaned from cells thoroughly increasing the patients risk for infections (Grossman, S., & Grossman, L. 2005). However, the severity of CF depends on whether the patients have complete or partial loss of the CFTR gene. If the person has the classic form of CF abnormalities of CFTR will commonly affect “…the respiratory, gastrointestinal, endocrine and metabolic, and genitourinary systems”(Schram, C. 2012). However, if people have atypical forms of CF their genetic disorder may only affect one of the organ systems and may not be found until the patient develops symptoms in their late childhood, early adolescence, or adulthood

Cystic Fibrosis is caused by a genetic defect in Chromosome 7. Chromosome 7 encodes the cystic fibrosis transmembrane conductance regulator, also known as CFTR. There are over 1,000 mutations of this gene causing cystic fibrosis, with each mutation manifesting as a different variation of disease onset and clinical presentation. The most common mutation is the loss of phenylalanine residue at deltaF508. The abnormal functioning CFTR causes impaired chloride transport and more viscous secretions. The defect causes dehydrated secretions in the respiratory tract and gastrointestinal tract. Being dehydrated, these secretions become more difficult to move throughout the body. Along with impaired

Tuberculosis is a bacterial infection disease characterized by the growth of nodules in the tissues, especially the lungs. Tuberculosis is also known as TB. TB can affect anyone if they are exposed to the air droplets of an affected person. TB can affect areas of the body other than the lungs. TB is high contagious and should be take seriously. If gone untreated it can be fatal.

Tuberculosis (TB) is a contagious bacterial infection that affects the lungs. Mycobacterium Tuberculosis is the bacterium that causes tuberculosis. Before the 19th century the frequency of TB was relatively unknown its incidence is thought to have peaked between the end of the 18th century and the end of the 19th century.