The Relationship Between Hpv And Cervical Neoplasia

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Evidently, in the 1990s the relationship between HPV and cervical neoplasia was confirmed.[7] According to Bosch et al., the 1990s produced the key results of case-control and cohort studies, and witnessed an increasing number of results on the clinical uses of HPV-DNA testing in screening and triage, [24] and, as Liaw et al. (1995) noted in their case control studies, it was also becoming apparent that those with multiple HPV infections have a higher risk of developing cancer of the cervix. [26] With the changing dimension of research studies having confirmed that HPV was a necessary cause of cervical cancer, epidemiological studies advanced to associating different strains of HPV to different anogenital pathologies, categorizing different histological forms of cervical cancer in relation to HPV strains and highlighting other risk factors that may play a prominent role or catalyze the carcinogesis process. For instance, Ngelangel et al. (1998) in their hospital-based case control studying the Philippines detected HPV-DNA in 93.8% case subjects with squamous cell carcinoma, 90.9% in case subjects with adenocarcinoma/adenosquamous carcinoma as opposed to just 9.2% of control subjects.[27] They observed the presence of fifteen different HPV types in squamous cell carcinoma, and six different HPV types in adenocarcinoma/adenosquamous carcinoma while noting that, apart from HPV 16 and HPV 18, HPV45 had the strongest association with squamous cell carcinoma. [27] The same year
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