The Role Of Augmentation Of Dysfunctional Labor With Oxytocin
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Objective: To re-evaluate whether augmentation of dysfunctional labor with oxytocin, has a hazardous effect on neonatal Apgar scores, umbilical artery pH or umbilical artery blood gases. Material and Methods: Prospective study where 153 patients in spontaneous labor were involved in the analysis. Seventy nine patients (Group I) with hypo-contractile uterine activity were managed by low-dose oxytocin protocol for labor augmentation, while 74 patients (Group II) didn’t need labor augmentation. Primary outcomes were Apgar score at 5 minutes of birth and umbilical artery pH, while secondary outcomes were Apgar score at 1 minute, arterial pO2, pCO2 and base deficit of all neonates. Results: There was no significant difference between group I…show more content… Utero-placental hypo-perfusion is the major cause of both respiratory and metabolic acidemia, with progression from the former to the latter over time if decreased utero-placental blood flow is not corrected (5), so various studies were designed to study the safety of using oxytocin infusion during the course of labor on neonatal clinical and acid-base condition at delivery and the likelihood of causing perinatal asphyxia.
Materials and Methods
The study was conducted in xxx (blinded for review) University Maternity Hospital and xxx (blinded for review) Teaching Hospital in Cairo, Egypt, which are two big tertiary hospitals, over a 10 months period, where 180 women in spontaneous labor were initially enrolled after informed consent and approval of the study protocol by the institute ethics committee. Ninety patients were diagnosed as primary failure of progression in labor due to hypo-contractile uterine activity and managed by augmentation of labor using low-dose oxytocin (Syntocinon® 10 IU/ml concentrate for solution for infusion) (Group I). Another group of ninety patients also fulfilled the selection criteria but didn’t need augmentation of labor and hence didn’t receive oxytocin (Group II). Participants were aged between 18 and 45 years old, free of medical disorders, suitable for vaginal delivery having singleton pregnancy at full term admitted at 3-5 cm cervical dilatation with vertex presentation of estimated fetal weight between 2500 to 4000 grams with