The Role Of Gamma Secretase And Its Effects On The Disease Of Alzheimer 's Disease

Alzheimer’s disease is a common problem in today’s society and within the older population this disease makes up the largest form of dementia. Although it is a problem in mainly older people, this disease can still occur in the younger population also. People in their 30s-50s can be diagnosed with this disease, even though it is not as common as people in their 60s-90s. The number of people with Alzheimer’s in the U.S. is close to five million and is expected to double within the next 30 years. With our modern medicine and advancements one would think a cure would be available, however, getting to the cause of the disease is a major factor. The cause of Alzheimer’s disease is one that is very debatable and questionable and most likely is a result of multiple factors rather than one. The main issue with finding the cause is because this disease affects the brain and can

Alzheimer’s Disease is a disease of the future. With the growing aged population, this disease, which affects primarily the elderly, will become of increasing relevance to the medical profession. Also, the high frequency of Alzheimer’s, and the high cost in labor, money, and material of caring for its victims shall put considerable burden on the society as a whole. Here, however, these issues are not going to be debated. Instead the pathology of Alzheimer’s will be reviewed to the extent it is known today.

The cause of Alzheimer’s is still mostly unknown except for one to five percent where genetic mutations have been identified as the cause. However there are many competing hypotheses that try to

Alzheimer 's disease which chronically leads to Senile Dementia, is a horrific change in homeostasis for human beings. The most obvious change in homeostasis from Alzheimer 's is loss of memory. Memory loss can vary from short term to long term. Alzheimer 's disease has been occurring in humans for a long time. This is a disease that affects different body systems, and interrupts homeostasis to a significant point. As Alzheimer 's disease is further investigated, there are more discoveries with how it is caused, what it affects, and how to reduce the risk of developing it. Alzheimer 's disease is a frightening disease that is represented in humans. There are many concerns with this disease that are worth finding out for the future victims

In 1906, Dr. Alois Alzheimer had a patient named Auguste D. He described this patient by saying she had “profound memory loss and unfounded suspicions about family” (Alzheimer, 1906). After his patient had died, he performed an autopsy to rule the cause of death. Alzheimer claims he found “dramatic shrinkage and abnormal deposits in and around the nerve cells”. His findings set new standards for understanding neuro-degenerative disorders around the world. In 1910, this newly discovered abnormality was coined as “Alzheimer’s Disease” (healthline.com). Researching soon ensued and scientists now had more information than ever. In 1976, Alzheimer’s was recognized as the most common cause of dementia. By 1984 Beta-amyloid was found present in brain

Alzheimer’s is one of the most common neurodegenerative disorders and causes for dementia and accounts for 50 to 70 percent of all cases of dementia. 4 million Americans suffer from Alzheimer’s and although there is no cure, progress is being made to develop drug treatments to slow the loss of mental functions in patients. Not only is Alzheimer’s one of the most common neurodegenerative disorders, but it is also one of the most mysterious. This is because the actual cause for the disease is

The alzheimer’s disease is a progressive disease that destroys memory and other important mental functions. Alzheimer's is not a normal part of aging and only up to 5 percent of people with the disease have early onset Alzheimer's (also known as younger-onset), which often appears when someone is in their 40s or 50s. This disease doesn’t have a cure, but there are treatments for symptoms available and research still continues to find the answer to cure this bad disease. Also, an interesting fact is that ninety percent of what we know about Alzheimer's has been discovered in the last 15 years. Lastly, Alzheimer's is a progressive disease, where dementia symptoms gradually worsen over a number of years. In its early stages, memory loss is mild, but with late-stage Alzheimer's, individuals lose the ability to carry on a conversation and respond to their environment. It’s the sixth leading cause of death in the United

Alzheimer’s disease or also known as Alzheimer’s is the neurodegenerative most common type of dementia that usually commences in older people; this is a very complex brain disorder that interferes with the affected individual’s life as soon as it initiates its mission of destroying the brain, it progresses slowly and gets worse over time from mild forgetfulness to brain impairment. Furthermore, scientist do not fully understand what causes this irreversible disease that has no cure or prevention and it may be inherited. Alzheimer’s disease seems to be caused by unusual plaques (beta-amyloid) and tangles in the brain, damaging important areas of memory and learning (Hanyu et al., 2010), together with, dementia is defined as a loss of mental

Alzheimer’s, a severe irreversible form of dementia, is now a very prevalent issue in the aging population. Scientists are just beginning to understand what Alzheimer’s is, what causes Alzheimer’s and how to prevent it. Although research has come a long way, “Alzheimer’s disease, as science tries to grasp it, seems to slip through our fingers. The complex interaction of neurochemistry, genetics, environment, lifestyle and personality all play a part in how individuals experience Alzheimer’s. ~ Harry Clayton

As Aβ peptide, under certain circumstances, is considered an important risk factor for the onset and progression of AD. Furthermore, APP (amyloid precursor protein), which is a transmembrane protein, is expressed and metabolized at high levels in the brain and through β and γ secretase enzymes produce Aβ (Seeman et al., 2011). Consequentially, targeting these enzymes by various drugs, can lead potential therapies, which may reduce Aβ accumulation and combat AD.

One of the most common forms of dementia in US is Alzheimer’s disease with an estimated 5.3 million Americans with Alzheimer’s disease in 2015 and approximately 700,000 patients of age 65 and older to die of this disease. Alzheimer’s has thus become the sixth leading cause of death in the U.S. Currently, one of the top 10 causes of death in America, Alzheimer’s disease progression cannot be slowed, cured or prevented. However, various researchers have been working on methods to decrease the progression or cure the disease, primarily focusing on the potentially modifiable risk factors.

Alzheimer’s disease is a neurodegenerative brain process that develops slowly over time. It is also known as senile dementia. Alzheimer’s disease is most widely thought to be caused by an increase in the production or accumulation of a specific protein (beta-amyloid protein) that leads to nerve cell death. This disease is thought to be inherited, though it does not mean that because either parent has it that the child will automatically have it. There is also a correlation that persons with limited formal education – less than eight years – are at an increased risk for Alzheimer’s disease. The likelihood of developing Alzheimer’s disease doubles every 5.5 years from age 65 to 85. The onset of Alzheimer’s disease can occur as early as 45 years

Alzheimer’s is a disease that affect the brain and it is a form of dementia. It causes problems with cognition such as memory, thinking, visual perception and behavior. It is a progressive disease, in other words, it worsens over time. The exact cause of this disease is unknown, however, studies have shown that certain conditions may predispose a person to Alzheimer, such as smoking, depression, diabetes and midlife high blood pressure, to name a few (McCane, Huerther, 2015)

Alzheimer 's disease is the most common type of dementia, affecting almost 500,000 people in the UK. The term dementia describes a loss of mental ability associated with gradual death of brain cells (NHS, 2013). This essay, provides an overview of Alzheimer’s disease, focusing on the amyloid hypothesis, which states that the accumulation and deposition of fibrillar -amyloid (beta-amyloid) is the primary driver of neurodegeneration and cognitive decline leading to dementia (Tanzi, 2005). Neurodegeneration is the progressive damage of nerve cells (News medical, 2014), and cognitive decline is a situation in which an individual’s ability to process thoughts and learn

Alzheimer's Disease is a condition that affects 50% of the population over the age of eighty five, which equals four million Americans each year. It is becoming an important and high-profile issue in today's society for everyone. There are rapid advancements being made in the fight against this disease now more than ever, and the purpose of this essay is to educate the public on the background as well as the new discoveries. There are many new drugs that are being tested and studied every day which slow down, and may even halt the progress of the disease.