The Role Of Inflammation On A Variety Of Mental Disorders

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Introduction The role of inflammation in a variety of mental disorders has recently become a topic of renewed interest (1, 2). There is now considerable evidence that acute psychotic and depressive episodes are associated with abnormalities in a range of inflammatory markers (3-5). There is also evidence that these disorders are longitudinally associated with inflammatory illnesses: maternal and childhood infections have been identifies as risk factors for schizophrenia (6, 7), and individuals with psychosis and depression are at increased risk of conditions with an inflammatory basis, such as diabetes and cardiovascular disease (8, 9). In bipolar disorder the evidence for an association is less well established (3, 10). There is…show more content…
From birth parents completed regular questionnaires about all aspects of their child’s health and development. From age 7, children attended a clinic to participate in various tests and interviews on an annual basis. ALSPAC has been used for a vast array of research topics (20). This study is based on the cohort of 7809 children who answered questions about atopic illness aged 10 years and the 4645 who had analysable blood samples taken aged 9 and were not acutely unwell. Informed consent for venepuncture was given for 7236 children. This was successfully completed such that IL-6 and CRP could be measured in 5076 individuals. Of these, 431 children reported an infection in the seven days preceding venepuncture and were excluded as we were interested in immune activity in healthy individuals. Of those who responded to the atopic illness questions, 2880 completed the hypomania assessment aged 21. 1721 of those with viable CRP and IL-6 results completed the assessment. In addition we repeated the analysis after imputation of missing data for all of those who answered the atopic illness questions (n=7809). Assessment of atopic disorders When participants were aged 10, parents completed a postal questionnaire which included the question: “Has a doctor ever actually said that your study child has asthma or eczema?” Possible responses to this question which are used in this study were: no
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