The Role Of Zinc In The Gastrointestinal System

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The aim of this article is to show the role of Zinc in the gastrointestinal system and its utility in children with diarrhea. Diarrhea remains a serious health problem in the developing countries and predominantly affects children under five years old. Diarrheal diseases are the second leading cause of death for children and one of the main causes of malnutrition in children under five. However, they are preventable and treatable diseases.
Malnourished refers to a pathological condition caused by lack of intake or absorption of nutrients including proteins, lipids, carbohydrates, vitamins and/or minerals. Malnutrition causes various health problems affecting the normal growth and development, can lead to mental and intellectual retardation
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3 of them with acute diarrhea and 4 with persistent diarrhea. The severity of diarrhea was evaluated in base of diarrheal stool output, the occurrence of dehydration, treatment failure, or death.
The results showed that administering a daily dose of about twice the RDA have relevant benefits in the duration and severity of acute and persistent diarrhea. Also, increments of plasma zinc levels were found in children that had lower baseline levels before starting the supplement.
The benefits of zinc are due to its influence on the intestinal permeability, regulation of intestinal water and electrolyte transport, brush border enzymatic function and intestinal epithelial tissue repair. Additionally, improving the immune
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The Oral rehydration therapy is very useful to prevent dehydration risk and, therefore, to reduce mortality rates from diarrheal disease. On the other hand, Zinc supplementation has shown effectiveness to diminish severity and duration related to the increase of morbidity and malnutrition in children under 5 years old. So, Zinc supplementation is an inexpensive and secure adjunctive therapy. Besides, it might avoid treatment of diarrhea with unnecessary antibiotics and other drugs. Zinc sulphate, Zinc acetate or Zinc gluconate are the commonly used at 20 mg per day for 10–14 days or 10 mg per day for infants under six months old. Presentation: tablets of 10 or 20 milligrams or syrup 10 mg/5 ml or 20 mg/5 ml. of elemental

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