The Role of Serotonin in Schizophrenia

Schizophrenia is classified as a mental disorder that shows profound disruption of cognition and emotion which affects a person’s language, perception, thought and sense of self. The dopamine hypothesis states that schizophrenic’s neurones transmitting dopamine release the neurotransmitter too easily, leading to the characteristic symptoms of schizophrenia. This hypothesis claims that schizophrenics have abnormally high amounts of D2 receptors; receptors that receive dopamine, therefore resulting in a higher amount of D2 receptors binding to the receptors causing more impulses. Dopamine neurotransmitters play a

Schizophrenia is a unique disease in its pathophysiology. For their early lives, patients appear healthy. However, symptoms begin to appear during adolescence or early adulthood and may be triggered by changes in the brain during puberty. The first signs of the illness include anxiety, depression, changes in friends, sleep problems, irritability, dropping grades, and having trouble concentrating (Picchioni and Murray, 2007; National Institute of Mental Health (NIMH)). Delusions and hallucinations typically begin between the ages of 16 and 30 (NIMH).

Expert’s reason that unevenness in the complicated interconnected chemical responses of the brain connecting the neurotransmitters dopamine and glutamate, and maybe others, performs a part in schizophrenia. Neurotransmitters are elements that permit brain cells to interconnect with each other. Experts are acquiring more about brain chemistry and its connection to schizophrenia. Similarly, in small methods the brains of people with schizophrenia appear diverse than those of healthful people. For instance, fluid-filled holes at the middle of the brain, called ventricles, are greater in certain people with schizophrenia. The brains of people with the disorder similarly manage to have less grey matter, and certain

Researchers believe that dopamine plays an important part in schizophrenia. The goal of conventional antipsychotic drug therapy is to reduce the amount of dopamine, or the amount of dopamine receptor sites. They are dopamine antagonists

Schizophrenia is classified as hysteria in our camaraderie. If you are diagnosed with schizophrenia, the world and our society now-a-days will deem you unfit and delusional. Schizophrenia is a disease that impinges approximately 1.1% of the population. I am going to be scrutinizing the effects of schizophrenia on the brain and personality. Schizophrenia is a diagnosed mental illness which is known for hallucinations (auditory, visual, tactile, sensory, etc.), and most people believe that if you are schizophrenic you are just psychopathic, and not credible. What I hope to discover is what schizophrenia actually does to the brain and personality, and if that assumption of a psychotic mentality is accurate.

(2) However, there are some problems with this evidense. Amphetamines only mimic the positive symptoms of schizophrenia. They do not produce any of the negative symptoms. Likewise, anti-psychotic drugs are only affective on the positive symptoms of the disease. There is still some evidense that schizophrenics do posess higher levels of dopamine, however, these increases are only found in the striatum of the brain (7). The striatum is a region of the brain that receives its inputs from and outputs to the cortex. Injury to the striatum results in problems with intiation and control of motor behavior. (9) Also, there is evidence that the prefrontal cortex produces lower levels of dopamine. (4) The prefrontal cortex is involved in the organization and coordination of information to and from the cortex. (7)

The vast majority of medications currently in the marketplace or under development to treat schizophrenia/psychosis focus on dopamine in one way or another. Most of the medications that are currently used to treat this condition affect dopamine in a direct way. These drugs specifically target this substance because historically, psychosis has been linked to unusually high levels of dopamine in the part of the brain that is known as the stratum (Nauert, 2010). Moreover, there is a fair amount of research that indicates there is a direct correlation between levels of glutamate, which is another substance the brain produces and is found in the hippocampus, and dopamine in individuals who eventually develop schizophrenia.

Dopamine is a neurotransmitter known to be involved in regulating mood and behaviour, amongst other things. Schizophrenia is associated with an overactivity of dopamine in the brain, and this may be associated with the delusions and hallucinations that are a feature of this disease.

Dopamine is a neurotransmitter associated with attention. Schizophrenics seem to have an increased number of D2 dopamine receptors on receiving neurons. This theory is support by the fact that Phenothiazines bind with D2 receptors and reduce positive symptoms. Another piece of supporting evidence is that Parkinson’s disease drug L-dopa, increase the level of dopamine and causes schizophrenic like symptoms in some people. However excess dopamine can only explain some types of schizophrenia, usually positive rather than negative.

Over the years, experiments have produced evidence to suggest that dopamine plays a role in the development of Schizophrenia (Howes, McCutcheon, & Stone, 2015). Dopamine is a neurotransmitter that is produced in the substantia nigra and ventral tegmental regions of the brain. The belief that dopamine was involved in Schizophrenia arose after multiple studies performed with compounds produced an increase in extracellular concentrations of dopamine (Lieberman, Kane, & Alvir, 1987). The patients that were administered these compounds had similar symptoms to those observed from patients who were diagnosed with Schizophrenia (Lieberman et al., 1987).

Another major problem with the dopamine theory is that it only takes into consideration a single neurotransmitter and neglect the roles of other neurotransmitters in schizophrenia. The findings are inconsistent where some findings proposed that the abnormality causes the availability of dopamine transporters changed, and effect to the increased or decreased of dopamine level (Fusar-Poli, and Meyer-Lindenberg, 2012), while some other findings suggested that there are other neurotransmitter such as glutamine which involved in excitatory response in the brain has played a role in resulting cognitive deficits of schizophrenia (Stone, Howes, Egerton, Kambeitz, Allen, Lythgoe, et al, 2010). These assumptions have allowed researchers to implicate schizophrenia by using another pathway or biochemical mechanism other than dopamine hypothesis or dopaminergic

Schizophrenia is not yet fully understood, but it is known that it is characterized by extreme disturbances in many vital areas, including behavior, emotions, speech, perception and thinking. The term schizophrenia means

The Dopamine Hypothesis theorizes that the symptoms portrayed in Schizophrenia is can be explained by abnormal function of dopamine in the brain. There have been three versions of the Dopamine Hypothesis. The first version of the hypothesis focuses on the dopamine receptors. Antipsychotic drugs that impact the metabolization and reabsorption of dopamine where found to be effective in treating the symptoms. It was theorized that if the symptoms of a Schizophrenic episode can be treated by the use of dopamine

Schizophrenia has many criteria that is associated with it and it involves many different types of symptoms such as: First, Delusion which involves a disturbance in the content of thought, it occurs in more than 90% of patients at some time during their illness (Cutting,1995). They are numerous types of delusion which associates with schizophrenia and other psychotic disorders.

In some people's cases, Schizophrenia appears suddenly and without warning. But for most it comes slowly, with subtle warning signs and a gradual decline in functioning long before the first severe episode. “In the early phases of Schizophrenia people often seem eccentric, unmotivated, emotionless, and reclusive (Helpguide.org).” They may isolate themselves and not want to participate in daily activities such as playing with their children, going outside, or getting off the couch. They abandon their hobbies and they do not do well in their jobs. “The most common early warning signs of Schizophrenia include: social withdrawal, hostility or suspiciousness, deterioration of personal hygiene, having a flat and expressionless gaze, the inability to cry or express joy, inappropriate laughter or crying, depression, oversleeping or insomnia, odd or irrational statements, forgetfulness or the inability to concentrate, extreme reaction to criticism, and or strange use of words or way of speaking (Helpguide.org).” There are five types of symptoms of Schizophrenia. Positive is a symptom that involves having hallucinations or delusions. Negative is when one shows no emotion or flat behavior. Avolation is when a person shows little interest in whatever they are doing. Cognitive behavior is when you have disorganized speech or memory loss. Catatonic behavior is considered poor functioning such as your voluntary muscles