The Standardized Extract Of Ginkgo Biloba

761 WordsNov 9, 20154 Pages
The standardized extract of Ginkgo biloba EGb 761® is an herbal remedy, most extensively used for dementia and cognitive impairment and it is one of the best classified extracts (DeFeudis FV, Drieu K. 2000). This standardized extract contains 24% flavanol hetrosides and 6% terpenes (ginkgolide biolobalide) and is marketed in Europe as Rokan® and Tanakan® (Porsolt et al.,1990). Having a lower molecular weight EGb 761 can cross blood brain barrier and produces various pharmacological effects on central nervous system (DeFeudis FV, Drieu K. 2000). In recent studies it is seen that Ginkgo biloba extract (120-600 mg) enhances to some extent many cognitive processes in healthy young individuals as well as old aged individuals suffering from impaired cognition (Silberstein et al., 2011). In spite of being easily tolerated it shows mild side effects in humans such as allergic reactions, GIT disturbances, nausea, headache, dizziness, heart palpitation, restlessness, and weakness whereas LD-50 ranging from 1100-7725 mg/kg body weight of mice or rats shows low acute toxicity (Frensin et al., 2010) . G. biloba extract has been known for enhancing the cerebral and peripheral blood flow (Winter, E. 1991) inhibiting corticosteroid synthesis to reduce stress (Marcilhac A et al., 1998), having antioxidative and free radical scavenging properties (Guidetti et al., 2001), inhibiting aggregation of amyloid-β (Luo et al., 2002), as well as growth factor upregulation to stimulate cell growth
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