The System Of The Human Body

There are many kinds of body systems, working together to create a functioning body. Different body systems work with certain body systems, but all work together. Like, nervous system and muscular system, circulatory system and respiratory system, and so on.

Coumadin (non specific name: warfarin) is an anticoagulant, or blood diminishing drug, that is endorsed to numerous patients who are at danger for creating blood clusters that could bring about heart assaults or strokes. Warfarin is near the most astounding purpose recently and simultaneous investigations of medications that provoke ER visits and occurring an expansion in healing center based offices with the affirmation of patients. Anticoagulation treatment stances perils to patients and over and over prompts unfavorable solution events in light of complex dosing, fundamental ensuing watching, and clashing patient consistence. As a result, various patients who meet current evidence based principles for warfarin treatment are not being managed

All the systems in the human body are vital to our survival and well-being. If you take away the functions of just one of these systems our whole body will cease to work properly. The main systems of the human body are the nervous, endocrine respiratory, circulatory, immune, digestive, excretory, skeletal, muscular, and the reproductive systems. They all work together in harmony and unison to keep us alive.

There are many people that suffer from venous thromboembolism. Venous thromboembolism includes both deep vein thrombosis and pulmonary embolism. This is the third most common cause of vascular death after a myocardial infarction, also known as a heart attack, and stroke. This article examines the possibility of either full or low intensity anticoagulation therapy versus aspirin. This was a randomized study that consisted of 3,396 individuals who have venous thromboembolism. These individuals either received rivaroxaban, which is an anticoagulant, or 100 mg of aspirin once a day. The individuals in this study completed 6-12 months of anticoagulation therapy and were eligible for inclusion in the study if they were 18 years of age or older. The

Enoxaparin is a low molecular weight heparin used to prevent thrombosis, particularly post surgery. Enoxaparin binds to antithrombin III which is responsible for inhibiting coagulation by acting on factor Xa. Enoxaparin accelerates the activity of antithrombin III therefore preventing clot formation (McKenna & Lim, 2014 p766). When a blood vessel is damaged, platelets in circulating blood stick to the site of injury and release chemicals that attract more platelets causing aggregation. There are both intrinsic and extrinsic pathways causing thrombi to form to maintain a closed cardiovascular system (Hollar, 2017). Immobility increases risk of thrombus formation as the blood becomes stagnant with gravity and decreased

Anticoagulant therapy will started according to facility protocol. This therapy will decrease the blood’s ability to clot, and help to prevent the formation of new clots. Anticoagulants used will be warfarin, heparin, or coumadin. In facility therapy will be initiated via IV push according to facility protocol, with continuous monitoring of patient condition.

The dabigatran etexilate (DE) is a prodrug that directly competes for the active site of thrombin.1 This direct inhibition inactivates both fibrin-bound and free form of thrombin. Because of its rapid onset and offset of action, there is no need for the initial parenteral anticoagulant treatment in patients with acute thrombosis.1 On the other hand, the enoxaparin indirectly inhibits factor Xa.2 It has a shorter duration of action (12h vs 24h) and a shorter half-life (4.5-7h vs 12-14h) in comparison to DE. The DE and the enoxaparin have no interaction with diet and alcohol. There is no routine monitoring required

Venous thrombosis is a multifactorial disease. In the majority of thrombosis patients a risk factor is not detectable. Virchow's triad refers to three primary influences for thrombus formation, endothelial injury, stasis, turbulence or abnormal blood flow, and blood hypercoagulability (Kyrle, 2009). A shift in balance between procoagulant and anticoagulant of the endothelium is responsible for thrombotic state (Kyrle, 2009). Endothelial injury is the physical loss of endothelium leading to exposure of subendothelial extra-cellular matrix, adhesion of platelets, release of tissue factor, depletion of PGI2 and plasminogen activators (Kumar, 2010). Abnormal blood flow refers to turbulence that causes endothelial injury, which is a major influence

Platelet transfusions may be given to people who are having severe bleeding episode. Minor bleeding from sites that can be seen, such as teeth and gums can be controlled by a local application of thrombin. Nosebleeds may require nasal packing (cocaine has been used on packing material) as well as platelet transfusion. Antifibrinolytic drugs (rare) may help control bleeding and tooth decay. Heavy menstrual cycles may require hormonal therapy to help control bleeding. Patients are likely to require multiple transfusions during their lifetime; doctors try to avoid platelet alloimmunization. Prevention of alloimmunization is best accomplished by using leukocyte depleted blood products. The only way to accomplish blood products with leukocyte depletion is with mechanical filtration. Only filtered blood products should be given. Another attempt in preventing alloimmunization is the use of HLA- matched platelets. Patients should be vaccinated for hepatitis B, due to the risk of infection associated with multiple transfusions. Patients should always avoid medications that affect platelet functions, such as aspirin in known blood thinners like warfarin. They should also avoid any nonsteroidal anti-inflammatory drugs (NSAID) such as ibuprofen and naproxen. These drugs can prolong bleeding

The pharmacological intervention includes the use of low molecular weight heparin (LMWH) and low-dose unfractionated heparin (LDUH). A finding of the study suggests that there is a significant reduction of VTE (13%) using thrombo-prophylaxis than without using any thrombo-prophylaxis (27%) and the single use of LDUH decreases the case with 15% (McNamara, 2014, pp.645). Furthermore, the study elaborates the use of aspirin could be an intervention to minimize the VTE but there is a chance of gastrointestinal bleeding. Thus, aspirin and other antiplatelet drugs are less effective methods to reduce VTE. Moreover, the pharmacological method is not effective in certain case that is associated with bleeding disorder. Therefore, there is a need of non-pharmacological preventive

Warfarin is a prescription medicinal drug used to save you harmful blood clots from forming or developing large. useful blood clots prevent or prevent bleeding, but dangerous blood clots can reason a stroke, coronary heart attack, deep vein thrombosis, or pulmonary embolism. because warfarin interferes with the formation of blood clots, it's far referred to as an anticoagulant. Many humans check with anticoagulants as “blood thinners”; but, warfarin does now not thin the blood but rather reasons the blood to take longer to form a clot. Warfarin decreases the body’s capability to form blood clots through blocking the formation of diet k–established clotting elements. diet okay is needed to make clotting elements and prevent bleeding. therefore,

In a hospital setting, anticoagulants and antiplatelets are widely prescribed by physicians because of their greater benefits in changing the physiological homeostasis of the cardiovascular system. Anticoagulants and antiplatelets play a fundamental role in the treatment of cardiovascular diseases as they are very effective at counteracting the different symptoms cardiovascular diseases present.

Bleeding is one of warfarins most serious and harmful effects as major and fatal bleeding can be experienced by patients. A meta analysis of 33 studies concluded “The clinical impact of anticoagulant-related major bleeding in patients with venous thromboembolism is considerable” therefore the effects of bleeding should be taken into account by health care professionals when choosing whether to prescribe warfarin to a patient or to continue anti-coagulant therapy using warfarin in individual patients. In addition to bleeding another complication of warfarin is its narrow therapeutic index which makes it difficult to ensure patients stay within the required anticoagulation range. An analysis of 6454 patients taking warfarin for atrial fibrillation

The Muscular and Nervous Systems of our body are two of eight major body functional systems that help us maintain homeostasis or in a chemical balance within our bodies. When the body cannot maintain homeostasis there is usually some sort of sickness or disease that is targeting one of our major body functions. An example of two diseases that could affect our homeostasis within our Muscular and Nervous System are Hydrocephalus and Dystonia.

Even though the brain is the major control center if the body, its job would not be possible without the spinal cord. The spinal cord is the major organ that helps information travel between the body and the brain. Nerves branch in the peripheral system from, either the brain stem or spinal cord, each nerve attaches to a specific area of the torso and limbs it 's responsible for communication to and from those regions. There are three very important