The Theory Of Cancer Stem Cell Theory

Cancer is a genetic disease caused by certain changes to genes that control the way our cells function, especially how they grow and divide. Genes carry the instructions to make proteins, which do much of the work in our cells. Certain gene changes can cause cells to evade normal growth controls and become cancer. Genetic changes that promote cancer can be inherited from our parents if the changes are present in germ cells, which are the reproductive cells of the body (eggs and sperm). Such changes, called germline changes, are found in every cell of the offspring. In general, cancer cells have more genetic changes than normal cells. But each person’s cancer has a unique combination of genetic alterations.

Cancer, medically called ‘tumorigenesis’ (Thaker, Lutgendorf, & Sood, 2007, p.430) occurs when cells in the body orient themselves for malignant growth. Such cells show ‘self-sufficiency in growth signals’, are ‘insensitive to anti-growth signals’ and have ‘limitless replicative potential’ (Thaker, Lutgendorf, & Sood, 2007, p.430). Once a particular set of cells become malignant, the malignancy can spread to other set of cells in different organs due to ‘crosstalk’ between the affected cells and their surrounding ‘tissues’ and ‘micro-environments’(Thaker, Lutgendorf, & Sood, 2007, p.430).

Cancer is described as the abnormal growth of cells. Normal cells are replaced with abnormal cells in which their deoxyribonucleic acid (DNA) has been damaged or augmented (McCance & Huether, 2014). Cancer cells with their various DNA changes are characterized by growing uncontrollably, being immortal with an unlimited lifespan

Cancer is a disease caused by an uncontrolled division of abnormal cells. The DNA sequence in cells can be changed as a result of copying errors during replication. If these changes whatever their cause are left uncorrected, both growing and non-growing somatic cells might gain many mutations that they could no longer function. The relevance of DNA damage and repair to the generation of cancer was obvious when it was recognized that everything that causes cancer also cause a change in the DNA sequence. Tumor suppressor genes are protective genes and normally they limit cell growth by monitoring the speed of cell division, repair mismatched DNA and control when a cell dies. When a tumor suppressor gene is mutated cells grow

There are two important type of genes responsible for the development or cancer namely tumor suppressor because their normal function is

An ordinary human body contains approximately one trillion cells and precisely 46 chromosomes in each cell. However, the human body can be altered by a genetic mutation. Over the course of history, genetic mutations have had a large impact on the human race. They have brought harm to numerous amounts of people. Cancer, in particular, is one of the most lethal diseases. Cancer begins when a portion of DNA inside a chromosome is damaged, causing a cell to mutate. Then, the mutated cell reproduces multiple times and creates a tumor. Afterwards, cancer cells break off of the tumor, enter the bloodstream, and disperse throughout the body. If the cells break off, the tumor is considered malignant - this type of cancer is very difficult to cure.

When cells in the body start dividing and regenerating uncontrollably, they lead to cancer – and this is true for all the cells in the body. If the cancer is not nipped in its bud early on, it can spread to other parts of the body. This presents the common question asked regards cancer; how can it be stopped early on? The same can be said for cancers that start from the bone marrow such as multiple myelomas.

Human life starts from a fertilized cell which breaks down, again and again, an adult human body is composed of the abundance of cells and each one have their own specific function to perform. During adulthood, most of the cell does not duplicate except some cells continue to divide to replace the old or damaged cell in blood, skin and intestine. This growth is very controlled and no excessive cell growth takes place. But sometimes when a mutation occurs in one or more genes which causes unnecessary cell reproduction and as a conclusion, there is no control over the growth of cells. It is called malignant transformation and this is the starting of cancer (Hosick et al., 2015). There are many different types of cancer but the early stage diagnosis

Cancer is listed as the second most common cause of death in western countries; particularly, in adults. Though it has a long antiquity, its prevalence and incidence today is pervasive and the war on cancer has not been promising. Malignant neoplasia is characterized by uncontrolled growth and the ability to metastasize or spread from the original site. Cancer results from mutations that promote cell proliferation and inhibit cell adhesion (metastasis). According to the National Cancer Institute (2016), “Cancer can also spread regionally,

First, we must understand what cancer is and how it forms, cancer is “a malignant and invasive growth or tumor, especially one originating in epithelium, tending to recur after excision and to metastasize to other sites.”1 it is when normal cells mutate and begin to reproduce at such an accelerated rate that body does not have time to get rid of these bad cells and a mass begins to grow creating a problem for the body.

Cancer is a disease that has been an ongoing controversy on what can help to prevent getting it. Cancer is when cells are dividing at an uncontrollable rate. Cancer is developed when cancer cells go into lymph nodes and also when they take over the blood vessels, lymph nodes are when there is swelling the the lymphatic system. With the cancer there is swelling which is called a tumor. Tumor is when there is swelling in the part of the body that is not caused by inflammation, but is caused by a large group of abnormal tissue cells. There are two different types of tumors. There is the malignant tumor which is a tumor that can be cancerous which is when the cells divide at a faster rate, and can also take over tissues. The other tumor is a benign tumor, which is a noncancerous and could be removed, and it cannot take over any near tissues. Genes play a big role in cancer itself. Cancer happens when a gene is mutated and changed, and when the gene becomes mutated it becomes abnormal. Because it is not a normal cell, its a mutated cell which makes it more cancerous. One gene that is a cancerous cell is a proto-oncogene which is a normal gene, but if it is mutated or changed it becomes a oncogene which is then now a cancerous cell and then divides into multiple different cancerous cells that can affect one 's body. The proto-oncogene can escalate if mutated into a cancerous cell. Which

Stem cells are a growing phenomenon in the cancer research world. Researchers are getting closer and closer to a cure, they are exploring other options to treat cancer. Stem cells are relatively new to the medical world, making their first appearance in 1956 (”Timeline for Stem Cell Research”, 1), and as with everything, there are flaws. Despite these flaws, stem cell treatment is something more people are turning to, as it is widely becoming one of the most popular ways to treat cancer (besides radiation and chemotherapy, respectively). Stem cell treatments are not accepted by all, as the rising questions are becoming, ‘Do stem cells worsen cancer?’, or better yet ‘Can stem cell treatments give rise to new types of cancer?’ My purpose in this paper is to discuss not only the bad, but also the good in stem cells.

Cancer is one of the leading causes of death worldwide as it can develop in almost any organ or tissue. Significant advances in understanding the cellular basis of cancer and the underlying biological mechanisms of tumour has been vastly improved in the recent years (Jiang et al. 1994). Cancer is a genetic disease which requires a series of mutation during mitosis to develop, its characteristics can be associated with their ability to grow and divide abnormal cells uncontrollable while in the mean time invade and cause nearby blood vessels to serve its need. Even though many people are affected by cancer today, the abilities which cancer cells have make it hard to find a single effective treatment for cancer. The focus of research now lies

Cancer is a terrible class of diseases that is characterized by abnormal cell growth. Cells can experience uncontrollable growth if there are damages or mutations to DNA. Specifically, the alteration of genes involved in cell division is responsible for the hypergenesis. When damaged cells divide uncontrollably they form lumps or masses of tissue called tumors. These tumors can either be malignant or benign. Benign tumors generally stay in one spot and demonstrate limited growth. Conversely, malignant tumors exhibit angiogenesis and invasion. Invasion is a process by which cancerous cells move throughout the body and grow into surrounding healthy tissues while angiogenesis is a process by which cells divide and propagate continuously making

Cancer occurrs by the production of multiple mutations in a single cell that causes it to proliferate out of control. Cancer cells often different from their normal neighbors by a host of specific phenotypic changes, such as rapid division rate, invasion of new cellular territories, high metabolic rate, and altered shape. Some of those mutations may be transmitted from the parents through the germ line. Others arise de novo in the somatic cell lineage of a particular cell. Cancer-promoting mutations can be identified in a variety of ways. They can be cloned and studied to learn how they can be controlled.