The Use Of Dmards

Rheumatoid arthritis is a systemic disease that affects whole systems of body particularly cardiovascular system, nerves, respiratory system (RACGP, 2009). The causes of rheumatoid arthritis are unknown but it is hereditary which assists to have a risk of rheumatoid arthritis by 50%-60% (RACGP, 2009).

Rheumatoid factor (RF): Rheumatoid factor is an antibody that is present eventually in the blood of most people with rheumatoid arthritis (3). Not all people with rheumatoid arthritis test positive for rheumatoid factor, and some people test positive for rheumatoid factor, yet never develop the disease(3). Rheumatoid factor also can be positive in some other diseases; however, a positive RF in a person who has symptoms consistent with those of rheumatoid arthritis can be useful in confirming a diagnosis. Furthermore, high levels of rheumatoid factor are associated with more severe rheumatoid arthritis (3).

Rheumatoid Arthritis(RA) is the most common type of autoimmune arthritis. RA is a progressive and debilitating musculoskeletal disorder that affects the joints symmetrically, causing a range of systemic effects. What it causes is still not well known; nevertheless, findings of new research points towards a believe that it is triggered by a defective immune system, which causes the release of inflammatory chemicals. These chemicals cause damage to cartilage and bone, usually affecting the wrists, the joints of the hand, including the knuckles, the middle joints of the fingers and feet. While this condition can affect any joints, besides, important body organs such as the eyes and the lungs can also be affected by the inflammation that occurs as a result of this chronic condition. Only in America 1.3 million of people are affected by this ailment, and 75 % of them are mainly women. Its onset usually occurs between fourth and sixth decades; however, RA can occur at any age("Diseases And

Rheumatoid arthritis is a chronic syndrome that is characterized by inflammation of the peripheral joints, but it may also involve the lungs, heart, blood vessels, and eyes. The prevalence of this autoimmune disease is between 0.3% to 1.5% of the population in the United States (Feinberg, pp 815). It affects women two to three times more often than men, and the onset of RA is usually between 25 and 50 years of age, but it can occur at any age (Reed, pp 584). RA can be diagnosed by establishing the presence of persistent joint pain, swelling in a symmetric distribution, and prolonged morning stiffness. RA usually affects multiple joints, such as the hands, wrists, knees, elbows, feet, shoulders, hips, and small

These types of disorders are sometimes treated by using TNF inhibitor. This inhibition is usually done with a monoclonal antibody such as Infliximab, an anti-TNF drug. Infliximab is used to treat rheumatoid arthritis by administering infliximab intravenously, in 6-8 week intervals (The British Pharmacology Society, 2011). Infliximab works by preventing TNF - alpha from binding to its receptors in the cell, as a result inhibiting TNF - alpha from carrying out functions in the immune response. Rheumatoid arthritis, is a disease associated with chronic joint inflammation, severe pain, stiffness, and swelling. Rheumatoid arthritis occurs when the body mistakenly attacks itself, in most cases inflammation is supposed to occur when the body is fighting off an invasion however with this disease, it occurs when the immune system malfunctions and starts to attack itself (Health Union,

Rheumatoid arthritis is a chronic, systemic inflammatory autoimmune disease. The disease happens when the immune system mistakenly attacks a healthy tissue as if it was a foreign invader, such as a virus or bacteria. If left untreated it can lead to permanent joint damage, decrease in quality of life, and total disability. It affects over a million people in the U.S. alone. Rheumatoid arthritis symptoms include persistent joint inflammation which causes joint pain, stiffness, and swelling. Fatigue and stiffness are usually early symptoms. Joint pain can be an early symptom in a variety of diseases. Symptoms of rheumatoid arthritis often develop slowly over a period of weeks or longer, but this is not always the case, it can have an acute

Rheumatoid arthritis is a chronic autoimmune disease that is characterized by inflammation and destruction of the joints (1). It usually affects joints asymmetrically, or on both sides of the body

If an individual is experiencing any of the above symptoms, many tests may be ordered to make a diagnosis. Laboratory tests may include rheumatoid factor, white blood cell count, anti-nuclear antibody, anti-citrullinated peptide/protein antibodies, erythrocyte sedimentation rate, and C-reactive protein. 70% of people

Blood tests may also be used to rule out other sources of joint pain such as rheumatoid arthritis

Definition: Rheumatoid arthritis is a chronic inflammatory disorder, which affects the small joints of hands and feets, and the lining of joints that causes painful swelling. The swelling can eventually result in bone erosion and joint deformity. It’s an autoimmune disorder, in which the immune system mistakenly attacks own body 's tissues. Rheumatoid arthritis not only causes a joint problem, but it can also affect other organs of the body such as the skin, eyes, lungs, and blood vessels.

After this is done, they will perform lab work to make sure you may not have any other conditions. When performing the lab work, they will be testing for five things. If C-Reactive Proteins are detected, this indicates the sign of inflammation in the body. Your erythrocyte sedimentation rate will be checked, as with rheumatoid arthritis, this is generally raised. Your Rheumatoid Factor will be checked as well, because “about 75% of people with rheumatoid arthritis are RF positive” (RA 101). Anti-cyclic citrullinated peptide will be tested, as “About 98% of people with RA have these antibodies in their systems” (RA 101). And lastly, an antinuclear antibody test would be done to make sure you do not have a

Rheumatoid arthritis (RA) is a systematic inflammatory disease characterized by synovitis (constant inflammation of the synovial membranes) and autoantibodies. The disease that affects 0.5-1.0% of all adults in industrialized countries, mostly women and elderly people (Scott et al, 2010). In the United States, more than 1.5 million people suffer from rheumatoid arthritis, making it one of the most common auto-immune disease (Carmona et al. 2010). According to the Arthritis Foundation, individuals who suffer from arthritis have to deal with joint pain, morning stiffness, fatigue, loss of appetite, depressive symptoms, and low-grade fever which can last a few days to weeks. Individuals with this disease tend to have a low-quality of life and difficulties with day-to-day activities.

If ones doctor suspects RA they may perform blood test to check for protein in the blood (This is present in about 2 in 3 people with RA. However, about 1 in 20 of the normal population has rheumatoid factor), and x-rays of the hands and feet may be done to detect any early deformations of the joints. If an individual’s doctor suspects that they may have RA, they usually will refer the patient to a rheumatologist who specialize in the joints and this type of disease. There is no cure for RA, but proper treatment for RA can make a big difference in reducing symptoms and to improve quality of life. Some of the main aims of treatment are: to decrease the disease from progressing to prevent joint damage, to reduce pain and stiffness in the affected joints, to minimize any disability caused by pain, joint damage, or deformities. A common medication prescribed for RA are disease modifying anti-rheumatic drugs (DMARDS) such as methotrexate, sulfasalazine, and hydroxychloroquine. This can be with medication such as steroids, NSAIDS, and often times will treat with pain killers because the pain is so intense. Eating a healthy diet and excising is always

     People who have rheumatic diseases should see a rheumatologist in order to determine the precise form of arthritis and the stage of the disease. General physical examination is necessary, beyond that there is a specific rheumatic disease exam that include blood tests, x-rays, and a complete exam of the joints. Blood tests are helpful to confirm diagnosis because they can check for factors that are typical of other chronic diseases as well as specific for

There are two blood tests that reveal the amount of inflammation in your body. One is the CRP, or C-reactive protein test, and the other is the ESR, or erythrocyte sedimentation rate test. If these tests have high results, it lets the doctor know you have damaging inflammation in your body. By looking at the results, the doctor can tell if your inflammation is severe or mild. The tests show the presence of inflammation, but they don't necessarily diagnose arthritis. Your doctor will take these blood test results into consideration along with other test results to determine if the inflammation is caused by arthritis.