The Use Of Mucus Between Normal Patients And Those With Asthma

1110 WordsApr 27, 20175 Pages
Rodgers and colleagues found a difference in the composition of mucus between normal patients and those with asthma. The mucus in asthma patients was noted to have different cross-linking, size, acidity and appearance as seen by electron microscopy (Rodgers,2007). It was concluded that the asthmatic mucus was formed by extremely large mucins assembled by the ‘normal’ sized subunits found in normal patients (Rodgers, 2007). More research needs to be done in the actual abnormality that seems to be present in the asthmatic mucus. Airway obstruction is the result of this hypersecretion of asthmatic mucus along with a combination of ciliary dysfunction. The mucus causes small diameter airways and a larger surface tension in parts of the…show more content…
It also appears that mast cells and macrophages have key roles in allergen-induced tissue remodeling (Maltby, 2017., 2017). An increase in mass of muscle, mucous glands, and tissue edema all lead to a thickened airway and decreased airflow throughout the lungs (Figure 4). These structural changes also are known as remodeling since they a complex morphological changes involving all of the structures in the bronchial walls (Bousquet et al., 2000) Remodeling occurs after inflammation and mucus cell hyperplasia have resolved (Maltby, 2017 et al., 2017). Some anatomic changes which young children and preadolescents are especially prone to include an increase in the anterior to posterior diameter of the chest, elevated clavicles, and a depressed diaphragm (Fireman, 2003). CLINICAL MANIFESTATION AND TREATMENT The symptom severity of asthma can be manifested as mild, moderate, or severe (Maltby, 2017 et al.) There are many symptoms and physical effects of asthma that can be seen in patients as well as through autopsies. Respiratory symptoms in those with asthma include: wheezing, breathlessness, chest tightness, and coughing (Valenta, 2017). A simple test to check if a person has asthma is a auscultation of breath sounds since normal breath sounds are distributed evenly over the lungs (Silverthorn,
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