The Von Willebrand Disease ( Vwd )

Hemophilia is an X-linked recessive disease in which blood lacks blood-clotting proteins. Females have two X chromosomes, indicating that they are generally carriers and transmit the gene to their sons. People with mild hemophilia bleed after surgery, injury, or trauma. Severe hemophilia produces spontaneous internal bleeding in joints and muscles. Fortunately, medicines and lifestyle changes offers hemophiliacs fairly normal lives. Through learning about hemophilia, I became interested in genetic diseases and finding a cure for those

The Europeans brought in diseases and Champlin to the First Nations that caused problems. To begin with, the diseases that were brought in by The Europeans caused the aboriginal population to decrease immensely. In particular, The Wendat people had no protection against diseases that the Jesuit priests and the coureurs de bois carried into their villages. The smallpox epidemic caused half of the population to die. As Historians estimated that the Wendat Confederacy 30,000- 40,000 people in 1535, by 1649 the wars and epidemics caused the Wendat confederacy to have a population less than 10,000. As a result, elders who were to carry on the traditions, knowledge, and skills of the community were gone. In addition, the Wendats that survived parted

This syndrome is from a mutation of a gene on chromosome 15 and this causes problems in the production of fibrillin-1 which is a protein that is an important part of connective tissue. The name for the gene is FBN1. Basically, it is the “glue” that helps to support the tissues in the human body. A child born to a parent with this syndrome has a 50% of having it. However, in the remaining 25%, neither parent has the disease which gives them a 1 in 10,000 chance of having a child with this disorder. When a child of two unaffected parents is born with it then the genetic mutation occurs in either the egg or sperm cell at the time of conception.

Schindler disease type III is intermediate in severity between types I and II. Affected individuals

Vertebrobasilar disease is a condition in which too little blood reaches the back of the brain. Vertebrobasilar disease can cause symptoms that interfere with day to day life, such as double vision. It also increases the risk of stroke and transient ischemic attack (TIA). Vertebrobasilar disease is also called vertebrobasilar insufficiency.

Fifth Disease also known as Erythema Infectious is a viral illness caused by the parvovirus B19. It is more common in children ranging from five to fifteen years of age than it is in adults. Most children will recover quickly without having any long lasting complications. Individuals may recognize the disease by the distinctive red rash that appears on the face that resembles a slapped cheek. Fifth disease has an incubation period ranging from four to fourteen days, however it can last as long as twenty days. Did you know that fifth disease gets its name for being listed number five on the list of historical classifications of common skin rash illnesses in children?

According to the National Hemophilia Foundation (n.d.), von Willebrand disease (VWD) is a genetic disorder caused by missing or defective von Willebrand factor (VWF), a clotting protein. VWF binds factor VIII, a key clotting protein, and platelets in blood vessel walls, which help form a platelet plug during the clotting process. The condition is named after Finnish physician Erik von Willebrand, who first described it in the 1920s (National Hemophilia Foundation, n.d.). The seriousness of the bleeding varied between family

People that have Wiskott Aldrich Syndrome also have another disorder called macrothrombocytopenia which is the specific part of the disorder that leads to the ability to not produce enough blood clots.

Erythema Infectiosum is called fifth disease. It is a mild illness caused by a virus. This virus most commonly occurs in children. The disease usually causes a bright red rash that appears on both cheeks. The rash has a "slapped cheek" appearance. Before the rash, the patient usually has a low-grade fever, mild upper respiratory symptoms, and a headache. One to three days after the cheek rash appears, a pink, lacy rash appears on the body, arms, and legs. This rash may come and go for up to 5 weeks. It often gets brighter following warm baths, exercise, and sun exposure. Your child may have no other symptoms or only a slight runny nose, sore throat, and very low fever. Complications are rare. This illness is quite

Imagine having a sibling you have to be extra careful with on day to day basis. Imagine the terror you feel when a loved one begins to bleed uncontrollably and you do not know what to do. Imagine the confusion and frustration you feel when you are helpless to your sibling. Having a sibling with von Willebrand disorder changes how families go about their daily routines. Von Willebrand disorder affects 1 in every 100 people, making it the most common bleeding disorder. About 75% of all people with von Willebrand have type 1, including my sister. Von Willebrand disorder causes excessive bleeding, easy bruising, and pure panic for a family. Blood transfusions are used on people

The exact cause of MVP is not known. Research has shown that valvular disorders tend to be hereditary and are common in people who are born with other disorders, specifically connective tissue, autoimmune, and skeletal disorders (Arapcic, 2011). Recently, researchers have also discovered a mutation in the DCHS1 gene that causes MVP (Durst et al., 2015). Patient X, a 50 year old African American female admitted with MVP, states she has been having a murmur since childhood and has been asymptomatic until recently.

In the article Asthma: Versatile Treatment for A Versatile Disease by Kevin R. Murphy, he discusses the many factors that affect asthma and how inhaled corticosteroid (ICS) are used for all different levels of asthma. Kevin R. Murphy brings up factors such as air pollution and smoking that contribute to the variable nature of asthma which affect people with asthma every day. I will be evaluating the points that Kevin R. Murphy made about the factors that affect asthma and how versatile treatment is for asthma.

Hemophilia A is an X-linked disorder caused by a deficient or defective clotting factor VIII (FVIII) protein, and characterized by spontaneous or traumatic bleeding into joints and muscles [Ragni]. It causes afflicted individuals to not be able to coagulate their blood very efficiently or at all when getting an injury in which blood is exposed either internally or externally. This disease can be very dangerous and fatal because major blood loss can occur if the patient has not received treatment.

Hemophilia is the oldest known hereditary bleeding disorder. There are two types of hemophilia, A and B (Christmas Disease). Low levels or complete absence of a blood protein essential for clotting causes both. Patients with hemophilia A lack the blood clotting protein, factor VIII, and those with hemophilia B lack factor IX. A person with severe hemophilia has less than 1% of the normal amount of a clotting factor - either Factor VIII (8) or Factor IX (9). People without hemophilia have between 50-150% of the normal level of factor VIII or IX. There are about 20,000 hemophilia patients in the United States. Each year, about 400 babies are born with this disorder. Approximately 85% have hemophilia A and the remainder has hemophilia B.

Occasionally a baby is born with this disorder and no family history of it. When this happens, it could be caused by a hidden gene, which is when several generations of female carry it, and it has not affected any male members of the family or a spontaneous mutation. With each pregnancy, a woman who is a carrier has a 25% possibility of having a son born with hemophilia. Since the father's X chromosome is what determines if the unborn child will be a girl, all of the daughters born of a man with hemophilia will be carriers. None of his sons, which is determined by the father through his Y chromosome, will have hemophilia. Individuals who suffer from mild hemophilia may choose to use a non-blood product known as Desmopressin acetate (DDAVP) to help treat the small bleeds and/or scrapes. For deep cuts or internal bleeding, the treatment called DDAVP may not be enough and therefore, may need a much more complex treatment. The clotting factor must be replenished so the affected person can form a clot to stop the bleeding. Plasma is one of the ‘human blood products’ than is used for factor replacement. Another factor replacement option is using the recombinant factor, which is produced in a laboratory.