The Von Willebrand Disease ( Vwd )

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¬Von Willebrand Disease (VWD) Named after the doctor that discovered the disease, Erik von Willebrand, von Willebrand Disease (VWD) is known as the most common clotting dysfunction affecting 1 out of every 100 to 1,000 people (NHLBI, 2011). In 1926, Dr. von Willebrand began to study a family that had a history of easy bruising and prolonged bleeding time (Mot, 2016). In 1985, the most significant progress was made in the research of the disease characterizing the von Willebrand factor gene which has led to an improved understanding of the genetics of VWD (Lillicrap, 2009). Von Willebrand Disease is complex and divided into 3 subtypes; Type 1, type 2 which is divided into 4 additional subgroups, and type 3. Type 1 VWD is the most common and accounts for 80% of the patient population, whereas type 2 accounts for 20-30%. Type 3 is classified as the rarest subtype of VWD and only accounts for 1% of all individuals diagnosed with VWD (Mot, 2016). These three subtypes are all caused by an inherited genetic mutation, but a form of the disorder, known as acquired Von Willebrand disorder, is linked to other disorders. All types of VWD vary in severity and are treatable, unfortunately though there is no cure. Von Willebrand Factor (VWF) VWD is a heterogeneous hemorrhagic disorder caused by a deficiency or dysfunction of the protein von Willebrand factor (VWF), which creates a defective interaction between platelets and the actual vessel wall. Primary hemostasis becomes impaired

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